N-Acetyl Selank (10MG)

What Is N-Acetyl Selank and Why Buy It for Research?

Buy N-Acetyl Selank in Switzerland for research into neuropeptide signaling, GABAergic modulation, and cognitive enhancement pathways. Specifically, N-Acetyl Selank (also known as Ac-Selank, Acetyl Selank, or N-Acetyl-Thr-Lys-Pro-Arg-Pro-Gly-Pro) is a synthetic acetylated heptapeptide with the sequence Ac-Thr-Lys-Pro-Arg-Pro-Gly-Pro-OH (one-letter code: Ac-TKPRPGP). It is the N-terminally acetylated derivative of Selank, a heptapeptide developed at the Institute of Molecular Genetics of the Russian Academy of Sciences.

Selank itself is a stabilized analogue of the endogenous immunomodulatory tetrapeptide tuftsin (Thr-Lys-Pro-Arg), a fragment of the immunoglobulin G heavy chain. Selank gained approval in Russia in 2009 as an intranasal anxiolytic for treating generalized anxiety disorder and neurasthenia. The N-acetyl modification involves covalent attachment of an acetyl group (CH3CO-) to the free alpha-amino group of the N-terminal threonine residue. The peptide has a molecular weight of approximately 793.9 Da and the molecular formula C₃₃H₅₇N₁₁O₉. The CAS number for the parent compound Selank is 129954-34-3.

In scientific research, N-Acetyl Selank serves as a molecular tool for studying neuropeptide signaling pathways, GABAergic modulation, and neuroimmune regulation. Furthermore, Core Peptides supplies N-Acetyl Selank as a lyophilized powder in a 10mg format exclusively for laboratory use. Therefore, researchers seeking to source this compound for their work will find it readily available when they buy N-Acetyl Selank in Switzerland.

N-Acetyl Selank Research Overview: Buy N-Acetyl Selank in Switzerland for Neuropeptide Studies

Centrally, research into N-Acetyl Selank has focused on its function as a stabilized analogue of Selank with enhanced resistance to enzymatic degradation. The acetylation protects the peptide from aminopeptidase-mediated cleavage, thereby extending its half-life and potentially improving bioavailability. Unmodified Selank has an exceptionally short plasma half-life of approximately 2-3 minutes, which necessitates frequent dosing for CNS delivery. Consequently, researchers designed the acetylated derivative to extend this half-life by reducing the rate of N-terminal enzymatic cleavage, potentially allowing lower doses and less frequent administration to achieve equivalent pharmacological effects.

N-Acetyl Selank mirrors the pharmacological profile of Selank, as acetylation does not alter the peptide’s receptor-binding pharmacophore. The pharmacological profile of Selank encompasses three primary domains: anxiolytic, nootropic, and immunomodulatory activity. The anxiolytic effects arise through allosteric modulation of GABA-A receptors, enhanced brain-derived neurotrophic factor (BDNF) expression in the hippocampus and prefrontal cortex, and modulation of serotonergic neurotransmission. Notably, unlike benzodiazepines, Selank and its N-acetyl derivative produce anxiolysis without sedation, cognitive impairment, tolerance development, or physical dependence.

The nootropic effects include enhanced memory consolidation, improved attention, and facilitated learning. Researchers attribute these effects to BDNF-mediated neuroplasticity, cholinergic modulation, and stabilization of enkephalin metabolism in the brain. The immunomodulatory dimension, inherited from its tuftsin core, involves stimulation of IL-6 expression, modulation of T-helper cell balance (Th1/Th2), and enhancement of monocyte/macrophage activity. Accordingly, researchers who buy N-Acetyl Selank in Switzerland from Core Peptides can support their investigations into neuropeptide signaling, GABAergic modulation, and neuroimmune regulation.

How Does N-Acetyl Selank Work in Research?

Mechanistically, N-Acetyl Selank’s proposed action involves functioning as a multi-target neuroactive peptide that modulates GABAergic, serotonergic, and neurotrophic pathways. The peptide operates through several interconnected mechanisms.

GABAergic Modulation

N-Acetyl Selank modulates the GABAergic system through allosteric modulation of GABA-A receptors. Research suggests that Selank may alter the binding properties of GABA to its receptors, perhaps via allosteric modulation, thereby influencing inhibitory neurotransmission. In neuronal preparations, Selank has been associated with a shift in specific GABA binding without necessarily altering affinity, indicating modulation of receptor state rather than direct agonism. By analogy, N-Acetyl Selank appears to retain or even tune such modulatory potential. Furthermore, unlike benzodiazepines, Selank and its N-acetyl derivative produce anxiolysis without sedation, cognitive impairment, or tolerance development.

BDNF Upregulation and Neuroplasticity

Studies associate N-Acetyl Selank with the rapid upregulation of brain-derived neurotrophic factor (BDNF) in hippocampal tissue in research models. This BDNF-mediated neuroplasticity contributes to the peptide’s nootropic effects, including enhanced memory consolidation, improved attention, and facilitated learning.

Serotonergic Neurotransmission

Research implicates Selank in modulating monoamine neurotransmitter concentrations, including serotonin metabolism and turnover. Evidence suggests that Selank may upregulate serotonin metabolism or availability in brain regions. Consequently, N-Acetyl Selank might influence serotonergic signaling more persistently or with different temporal profiles.

Enkephalinase Inhibition and Endogenous Peptide Regulation

Selank inhibits peptide-degrading enzymes (such as enkephalinases), thereby elevating endogenous regulatory peptides like enkephalins. If N-Acetyl Selank preserves or enhances such inhibitory capacity, it could serve as a modulator of endogenous peptide signaling systems. In research contexts focused on neuropeptide regulation, enkephalin turnover, or peptidase assays, N-Acetyl Selank may act as a chemical tool to transiently suppress peptidase activity.

Immunomodulatory Activity

The immunomodulatory dimension of N-Acetyl Selank, inherited from its tuftsin core, involves stimulation of IL-6 expression, modulation of T-helper cell balance (Th1/Th2), and enhancement of monocyte/macrophage activity. This positions N-Acetyl Selank as a uniquely multi-target compound that bridges the neuroimmune axis—addressing both the psychological and immunological components of stress-related disorders.

Why Is N-Acetyl Selank Studied in Switzerland?

Primarily, researchers study N-Acetyl Selank because it represents a well-characterized acetylated heptapeptide that enables investigation of neuropeptide signaling, GABAergic modulation, and neuroimmune regulation. In fact, this compound offers a focused tool for studying the molecular mechanisms underlying anxiety, cognitive function, and stress-related disorders.

Research has demonstrated N-Acetyl Selank’s relevance across multiple domains. For example, researchers have studied the peptide for its potential to modulate GABA-A receptor sensitivity, promoting inhibitory neurotransmission and anxiolytic effects. Selank has been shown to improve cognitive and emotional state in patients with generalized anxiety disorder. Furthermore, studies demonstrate that Selank attenuates aversive signs of morphine withdrawal and protects against ethanol-induced memory impairment by regulating BDNF content in the hippocampus and prefrontal cortex.

Moreover, investigators have examined N-Acetyl Selank for its neuroprotective potential and its ability to modulate the expression of genes involved in inflammation. The peptide also exerts antiulcerogenic action and promotes healing of experimental ulcers. Ultimately, researchers who buy N-Acetyl Selank in Switzerland gain access to a comprehensive research tool for investigating neuropeptide signaling, GABAergic modulation, and neuroimmune regulation.

N-Acetyl Selank Research Areas in Laboratory Studies

Research Area	Focus	Evidence Level
GABAergic Modulation	GABA-A receptor allosteric modulation, inhibitory neurotransmission, anxiolytic mechanisms	Mechanistic / Preclinical
BDNF and Neuroplasticity	BDNF upregulation, synaptic plasticity, memory consolidation, learning enhancement	Preclinical
Serotonergic Neurotransmission	Serotonin metabolism, monoamine modulation, receptor sensitivity	Mechanistic / Preclinical
Neuropeptide Signaling	Enkephalinase inhibition, endogenous peptide regulation, peptidase assays	Mechanistic / In Vitro
Immunomodulation	IL-6 expression, T-helper cell balance, monocyte/macrophage activity	Mechanistic / Preclinical
Cognitive Research	Memory consolidation, attention, learning, neuroprotection	Preclinical / Clinical
Stress and Anxiety Research	Anxiolytic effects, stress response, behavioral regulation	Preclinical / Clinical
Peptide Stability Studies	Aminopeptidase resistance, metabolic stability, enzymatic degradation assays	Mechanistic / In Vitro

N-Acetyl Selank Compared With Related Research Compounds

Compound	Research Focus	Mechanism / Target	Key Difference
N-Acetyl Selank	Anxiolytic, nootropic, immunomodulatory	GABA-A allosteric modulation, BDNF upregulation, enkephalinase inhibition	Acetylated heptapeptide; enhanced stability; multi-target profile
Selank	Anxiolytic, nootropic, immunomodulatory	GABA-A allosteric modulation, BDNF upregulation	Parent heptapeptide; shorter half-life (~2-3 min); Russian-approved drug
N-Acetyl Semax	Nootropic, neuroprotective, cognitive enhancement	BDNF upregulation, dopaminergic modulation	Different peptide sequence; stimulatory profile; complementary mechanism
Tuftsin	Immunomodulatory	Macrophage activation, immune regulation	Native tetrapeptide; parent compound; shorter half-life

Comparatively, N-Acetyl Selank differs from its parent compound Selank in its enhanced stability and potentially improved bioavailability. On the one hand, Selank is the parent heptapeptide approved in Russia as an anxiolytic, with a short half-life of approximately 2-3 minutes. On the other hand, N-Acetyl Selank features N-terminal acetylation that protects the peptide from aminopeptidase degradation, extending its half-life and potentially allowing lower doses.

Research Applications for N-Acetyl Selank in Switzerland

Scientists have investigated N-Acetyl Selank across several research domains:

• GABAergic Research: Researchers use N-Acetyl Selank to study GABA-A receptor allosteric modulation, inhibitory neurotransmission, and anxiolytic mechanisms.
• BDNF and Neuroplasticity Studies: The peptide is employed to investigate BDNF upregulation, synaptic plasticity, memory consolidation, and learning enhancement.
• Serotonergic Research: Studies have examined N-Acetyl Selank’s effects on serotonin metabolism, monoamine modulation, and receptor sensitivity.
• Neuropeptide Signaling: The peptide serves as a tool for studying enkephalinase inhibition, endogenous peptide regulation, and peptidase assays.
• Immunomodulation Research: Investigations have explored N-Acetyl Selank’s effects on IL-6 expression, T-helper cell balance, and monocyte/macrophage activity.
• Cognitive Research: The peptide has been studied for its potential to enhance memory consolidation, attention, and learning.

Evidently, researchers who buy N-Acetyl Selank in Switzerland gain a valuable addition to any laboratory toolkit focused on neuropeptide signaling, GABAergic modulation, and cognitive research.

N-Acetyl Selank Product Specifications

Specification	Details
Product Name	N-Acetyl Selank (Ac-Selank)
Alternative Names	Ac-Selank, Acetyl Selank, N-Acetyl-Thr-Lys-Pro-Arg-Pro-Gly-Pro, Acetylated Selank
Amount	10mg
Form	Lyophilized powder
Purity	Not verified
Amino Acid Sequence	Ac-Thr-Lys-Pro-Arg-Pro-Gly-Pro-OH
Sequence (1-letter)	Ac-TKPRPGP
Peptide Length	7 amino acids (heptapeptide)
Modification	N-terminal acetylation
Molecular Formula	C₃₃H₅₇N₁₁O₉
Molecular Weight	793.9 Da (approx.)
Parent Compound CAS	129954-34-3 (Selank)
Research Category	Cognitive & Nootropic / Immunity & Inflammation
Research Use	Laboratory research use only
CoA	Available upon request (not verified)
Storage	Lyophilized powder should be stored desiccated at -20°C or below, protected from light
Solubility	Soluble in water and bacteriostatic water

How to Evaluate N-Acetyl Selank Quality for Research

When sourcing N-Acetyl Selank peptide for laboratory research, researchers should consider several quality indicators:

• Identity Confirmation: Analytical techniques such as mass spectrometry should confirm the compound’s molecular weight (approximately 793.9 Da) and sequence (Ac-Thr-Lys-Pro-Arg-Pro-Gly-Pro-OH).
• Purity Assessment: High-performance liquid chromatography (HPLC) should verify purity, with ≥98% considered standard for research-grade material.
• Acetylation Confirmation: Analytical methods should confirm the presence of the N-terminal acetyl group.
• Batch Traceability: Lot numbers and batch information enable researchers to track specific production runs.
• Certificate of Analysis: A CoA should accompany the product, detailing analytical testing results including HPLC purity and identity confirmation.
• Labeling Accuracy: Proper labeling should clearly indicate the product name, amount (10mg), sequence, molecular formula, and storage recommendations.
• Storage Conditions: Appropriate storage at -20°C or below in desiccated, dark conditions helps maintain peptide stability.

Understanding the Certificate of Analysis

Typically, a Certificate of Analysis (CoA) accompanies research peptides and provides information about the specific batch’s analytical testing. For example, a CoA may include product identity confirmation, purity percentage as determined by HPLC, batch or lot number for traceability, analytical methods used (e.g., mass spectrometry, HPLC), and a physical description of the product.

Nevertheless, it is important to note that a CoA does not establish safety, efficacy, therapeutic effectiveness, or suitability for human use. Instead, it serves as a quality control document that helps researchers verify the identity and purity of the peptide they are using in their laboratory investigations.

Storage and Stability of N-Acetyl Selank

Core Peptides supplies N-Acetyl Selank as a lyophilized (freeze-dried) powder. To maintain stability and integrity:

• Store the lyophilized powder desiccated at -20°C or below for long-term storage
• Store at 4°C for short-term storage if frequent access is required
• Avoid repeated freeze-thaw cycles
• Weigh under dry conditions; the peptide is hygroscopic
• Reconstitute only immediately before use with appropriate sterile solvents (sterile water or bacteriostatic water)
• Inject solvent slowly against the inner wall of the vial; avoid vigorous agitation during dissolution
• Filter sterilize if required (e.g., 0.22 µm) immediately prior to use
• Aliquot and store reconstituted solutions at -20°C or below to minimize degradation
• Protect from light and moisture; prolonged exposure to light, elevated temperature, or aqueous environments may reduce stability

Frequently Asked Questions About Buying N-Acetyl Selank in Switzerland

What is N-Acetyl Selank?

Specifically, N-Acetyl Selank (Ac-Selank) is a synthetic acetylated heptapeptide with the sequence Ac-Thr-Lys-Pro-Arg-Pro-Gly-Pro-OH. It is the N-terminally acetylated derivative of Selank, a heptapeptide developed at the Institute of Molecular Genetics of the Russian Academy of Sciences based on the endogenous immunomodulatory tetrapeptide tuftsin.

What is N-Acetyl Selank researched for?

Primarily, researchers study N-Acetyl Selank for its role in GABAergic modulation, BDNF regulation, and neuropeptide signaling. Studies have investigated its effects on anxiolytic pathways, cognitive enhancement, and immunomodulatory mechanisms.

How does N-Acetyl Selank work?

Mechanistically, N-Acetyl Selank functions as a multi-target neuroactive peptide that modulates GABA-A receptors through allosteric modulation, upregulates BDNF expression in hippocampal tissue, influences serotonergic neurotransmission, and inhibits enkephalin-degrading enzymes.

What is the amino acid sequence of N-Acetyl Selank?

The amino acid sequence is Ac-Thr-Lys-Pro-Arg-Pro-Gly-Pro-OH (one-letter code: Ac-TKPRPGP).

What is the molecular weight of N-Acetyl Selank?

The molecular weight is approximately 793.9 Da.

What is the molecular formula of N-Acetyl Selank?

The molecular formula is C₃₃H₅₇N₁₁O₉.

What is the CAS number of N-Acetyl Selank?

The parent compound Selank has CAS number 129954-34-3. The acetylated form is not separately listed in major chemical databases.

Is N-Acetyl Selank synthetic?

Yes, N-Acetyl Selank is a synthetic peptide produced through solid-phase peptide synthesis with N-terminal acetylation modification.

How does N-Acetyl Selank differ from Selank?

N-Acetyl Selank features N-terminal acetylation that protects the peptide from aminopeptidase degradation, extending its half-life and potentially improving bioavailability. Selank is the parent heptapeptide approved in Russia as an anxiolytic with a short half-life of approximately 2-3 minutes.

What research exists on N-Acetyl Selank?

Research on N-Acetyl Selank is primarily extrapolated from the Selank literature, as the acetylated form has not been independently evaluated in published clinical trials. Selank has been studied in Russian clinical trials for generalized anxiety disorder and neurasthenia.

Where can I buy N-Acetyl Selank in Switzerland?

You can buy N-Acetyl Selank in Switzerland from Core Peptides, a trusted research peptide supplier serving the Swiss scientific community.

How should researchers evaluate N-Acetyl Selank quality?

Researchers should look for identity confirmation via mass spectrometry, purity data from HPLC, acetylation confirmation, batch traceability, and a Certificate of Analysis.

Related Research Compounds

Researchers interested in N-Acetyl Selank may also find the following related compounds relevant to their work:

• Selank — The parent heptapeptide from which N-Acetyl Selank is derived, researched for anxiolytic, nootropic, and immunomodulatory effects.
• N-Acetyl Semax — An acetylated heptapeptide with complementary nootropic and neuroprotective mechanisms, frequently combined with Selank in research protocols.
• Semax — The parent heptapeptide of N-Acetyl Semax, researched for cognitive enhancement and neuroprotection.
• BPC-157 — A peptide researched for tissue healing, gastrointestinal protection, and angiogenesis.

Explore Cognitive & Nootropic

N-Acetyl Selank belongs to the Cognitive & Nootropic category of research compounds. Cognitive & Nootropic products are studied for their potential roles in cognitive enhancement, neuroprotection, and nervous system regulation. Generally, researchers who buy N-Acetyl Selank in Switzerland often pair it with related compounds in this category to explore complementary pathways in cognitive and neuropeptide research.

Explore Immunity & Inflammation

Researchers studying immunomodulation, neuroimmune regulation, and inflammatory signaling may also find relevant compounds in the Immunity & Inflammation category. N-Acetyl Selank’s tuftsin-derived immunomodulatory properties make it a valuable tool for investigating the neuroimmune axis and stress-related immune responses.

Further Research

For researchers seeking to deepen their understanding of N-Acetyl Selank and its research applications, the following areas may warrant further investigation:

• The relationship between N-Acetyl Selank-mediated GABAergic modulation and specific downstream effects on anxiety and stress responses
• Comparative studies between N-Acetyl Selank and Selank in various neuropeptide and cognitive models
• The potential role of N-Acetyl Selank in modulating BDNF expression and neuroplasticity pathways
• Mechanistic studies on N-Acetyl Selank’s interaction with GABA-A receptors and its functional consequences for inhibitory neurotransmission
• Exploration of N-Acetyl Selank’s effects on different cell types and tissue systems beyond the central nervous system

Research Disclaimer

Researchers must not use it for human consumption, injection, or any form of therapeutic application. Moreover, this product is not a medicine, pharmaceutical, or medical device. Furthermore, Swissmedic, the FDA, EMA, or any other regulatory authority have not approved it for human use. Researchers should consult Swissmedic for applicable regulations and guidance on research peptide handling in Switzerland.

Generally, the information provided on this page is for educational and scientific reference purposes only. Therefore, it does not constitute medical advice, treatment recommendations, or dosing instructions. Ultimately, researchers bear the responsibility for ensuring that their use of this product complies with all applicable laws, regulations, and institutional guidelines.