Selank (10MG)

What Is Selank?

Selank is a synthetic heptapeptide with the amino acid sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP). It belongs to a class of peptide-based compounds developed as analogs of tuftsin a naturally occurring tetrapeptide (Thr-Lys-Pro-Arg) derived from the Fc fragment of immunoglobulin G (IgG) that plays a role in immune system regulation. Researchers originally developed Selank at the Institute of Molecular Genetics of the Russian Academy of Sciences as a synthetic analog of tuftsin with extended pharmacological properties.

As a heptapeptide a peptide composed of seven amino acids Selank represents the tuftsin tetrapeptide extended at the C-terminus by a Pro-Gly-Pro sequence. This structural modification enhances the peptide’s stability and biological activity while preserving its immunomodulatory properties. For those looking to buy Selank in Switzerland, Core Peptides offers high-quality research-grade material for laboratory applications.

Selank Research Overview

Selank has attracted significant research interest as a synthetic peptide with pronounced anxiolytic (anxiety-reducing) and nootropic (cognitive-enhancing) properties. Unlike traditional benzodiazepines, which act as direct agonists at GABA-A receptors, Selank functions as a positive allosteric modulator of GABAergic neurotransmission. This distinction may account for its reduced side-effect profile, as Selank does not produce sedation, dependence, or withdrawal symptoms typically associated with benzodiazepine-class compounds.

Research interest in Selank centers on its multifaceted mechanism of action, which includes GABAergic modulation, enkephalinase inhibition, BDNF upregulation, and anti-inflammatory effects. Studies have demonstrated that Selank produces anxiolytic effects comparable to traditional benzodiazepines while also enhancing cognitive function and stress resilience. Consequently, Selank has generated significant interest as a research tool for investigating anxiety disorders, cognitive function, neuroplasticity, and stress-related conditions.

When researchers choose to buy Selank in Switzerland for laboratory studies, they gain access to a compound that may help elucidate mechanisms of GABAergic signaling, neurotrophic factor regulation, and stress resilience at the molecular level.

How Does Selank Work?

Selank exerts its biological effects through multiple interconnected mechanisms, including allosteric modulation of GABA-A receptors, inhibition of enkephalin-degrading enzymes, and regulation of neurotrophic factor expression.

GABA-A Receptor Modulation

Selank’s primary anxiolytic mechanism involves positive allosteric modulation of GABA-A receptors. Unlike benzodiazepines, which bind to the benzodiazepine site on GABA-A receptors, Selank appears to act through a distinct allosteric binding site, modulating receptor function without directly activating the receptor. This mechanism enhances inhibitory GABAergic neurotransmission, producing anxiolytic effects without the sedation, tolerance, and dependence associated with benzodiazepines.

Research has shown that Selank’s biological effects result from a combination of direct modulating action on target receptors and the initiation of biochemical cellular mechanisms that determine the molecular basis of the peptide’s physiological effects.

Enkephalinase Inhibition

Selank also plays a critical role in the enkephalinergic system by inhibiting enkephalin-degrading enzymes. By slowing the breakdown of endogenous enkephalins, Selank increases the half-life of these natural anxiolytic peptides in the brain. This mechanism contributes to the peptide’s anxiolytic effects and may also influence pain modulation and stress responses.

BDNF Upregulation and Neuroplasticity

A key component of Selank’s nootropic effects is its ability to increase Brain-Derived Neurotrophic Factor (BDNF) expression. Selank administration leads to higher levels of BDNF, which then binds to its high-affinity receptor, Tropomyosin receptor kinase B (TrkB). This activation triggers downstream events crucial for synaptic plasticity and memory consolidation.

Furthermore, Selank modulates neurotransmitters such as serotonin and dopamine, which may contribute to its mood-stabilizing and cognitive-enhancing effects. The peptide’s influence on these monoamine systems, combined with its BDNF-elevating properties, supports its role in promoting neuroplasticity and stress resilience.

Immunomodulatory and Anti-Inflammatory Effects

As a tuftsin analog, Selank retains immunomodulatory properties, including effects on antigen processing, presentation, and the complement system. Research has demonstrated that Selank mitigates ischemia-induced alterations in transcriptional activity, compensating for the effects of ischemia on gene expression. Studies have also shown that Selank affects intestinal microbiota and colon wall condition in stressed animal models.

Researchers who buy Selank in Switzerland for research purposes can investigate these mechanisms across diverse experimental models of anxiety, cognition, neuroplasticity, and stress resilience.

Why Is Selank Studied?

Researchers study Selank primarily for its potential relevance to anxiety disorders, cognitive enhancement, and neuroplasticity. The peptide’s ability to modulate GABAergic transmission, inhibit enkephalin degradation, and upregulate BDNF expression makes it a valuable tool for understanding the molecular basis of anxiety, learning, memory, and stress resilience.

The peptide’s connection to the tuftsin immunomodulatory system has made it a focus of neuroimmunology research. Preclinical studies have explored Selank’s effects on anxiety-related behaviors, cognitive function, and stress responses in various experimental models, including rodent behavioral paradigms and transcriptomic analyses.

Moreover, researchers study Selank in the context of neuroprotection and recovery from neurological insults. Transcriptomic studies have shown that Selank acts at the molecular genetic level to regulate processes triggered by cerebral ischemia, including neural pulse transmission and immunity. The peptide’s anti-inflammatory and neurotrophic properties may offer insights into mechanisms of neural repair and recovery.

Researchers who buy Selank in Switzerland from Core Peptides can incorporate this peptide into their studies on anxiety, cognition, neuroplasticity, neuroimmunology, and stress-related conditions.

Selank Research Areas

Research Area	Description
Anxiolytic Research	Investigating Selank’s anxiety-reducing effects via GABA-A receptor modulation
Cognitive Enhancement	Studying Selank’s nootropic effects on learning, memory, and cognitive performance
Neuroplasticity	Examining Selank’s BDNF upregulation and effects on synaptic plasticity
Enkephalinase Inhibition	Exploring Selank’s inhibition of enkephalin-degrading enzymes
Neuroimmunology	Investigating Selank’s immunomodulatory and anti-inflammatory properties
Stress Resilience	Preclinical research into Selank’s effects on stress responses and coping mechanisms
Neuroprotection	Studying Selank’s protective effects in models of cerebral ischemia and neural injury
Serotonin & Dopamine Modulation	Exploring Selank’s effects on monoamine neurotransmitter systems

Scientific Research on Selank

Researchers have conducted scientific studies on Selank in both in vitro and in vivo settings, deriving evidence from cell cultures, rodent models, and human clinical research. The peptide originates from the tuftsin analog research program at the Institute of Molecular Genetics of the Russian Academy of Sciences.

In Vitro Evidence

In vitro studies have demonstrated that Selank acts as a positive allosteric modulator of GABA-A receptors, enhancing inhibitory neurotransmission without directly activating the receptor. The peptide also inhibits enkephalin-degrading enzymes, increasing the half-life of endogenous enkephalins.

Research has shown that Selank’s biological effects result from a combination of direct modulating action on target receptors and the initiation of biochemical cellular mechanisms that determine the molecular basis of the peptide’s physiological effects.

Preclinical Animal Studies

In rodent models, researchers have investigated Selank’s effects on behavior and neurochemical processes. Studies have demonstrated that Selank at a dose of 100 μg/kg produced an anxiolytic effect in the open-field test and increased the half-life of plasma leu-enkephalin in BALB/c mice. Research has also shown that Selank recovers learning and memory in animal models.

Transcriptomic studies have revealed that Selank acts at the molecular genetic level to regulate processes triggered by cerebral ischemia, including neural pulse transmission and immunity. The peptide has been shown to mitigate ischemia-induced alterations in transcriptional activity, compensating for the effects of ischemia on gene expression. Selank was found to be active towards genes involved in neural pulse transmission and immunity, including antigen processing and presentation and the complement system.

Furthermore, studies have examined Selank’s effects on intestinal microbiota and colon wall condition in Wistar male rats subjected to restraint stress, demonstrating the peptide’s impact on the gut-brain axis.

Human Research

Selank has been studied in human clinical research and has entered clinical practice in Russia as an anxiolytic agent with stimulating, nootropic, and emotional-normalizing effects. The peptide’s anxiolytic efficacy is reported to be comparable to that of traditional benzodiazepines, but with minimal side effects and no sedation or dependence.

Functional connectomic studies have assessed the effects of Selank and the related nootropic peptide Semax on whole-brain resting-state functional connectivity in healthy participants. These studies provide insights into the neural networks modulated by Selank administration.

Nevertheless, researchers should note that while Selank has been used clinically in Russia, the peptide is supplied for laboratory research purposes only. Scientists who buy Selank in Switzerland should remain aware of these evidence considerations.

Selank Compared With Related Peptides

Peptide	Relationship to Selank	Key Differences
Tuftsin	Parent compound; Selank is a tuftsin analog	Tuftsin is a tetrapeptide (Thr-Lys-Pro-Arg); Selank is a heptapeptide with C-terminal Pro-Gly-Pro extension for enhanced stability
Semax	Developed alongside Selank; both are Russian nootropic peptides	Semax is an ACTH(4-10) analog with different mechanism; Selank is a tuftsin analog targeting GABAergic system
Afobazole	Both studied for anxiolytic effects	Afobazole is a non-peptide anxiolytic; Selank is a peptide with additional nootropic properties
Benzodiazepines	Both produce anxiolytic effects	Benzodiazepines are direct GABA-A agonists with sedation and dependence; Selank is a positive allosteric modulator with minimal side effects
Noopept	Both studied for cognitive enhancement	Noopept is a dipeptide with different mechanism; Selank combines anxiolytic and nootropic effects

Research Applications

Researchers utilize Selank in a variety of laboratory research applications, primarily in the fields of neuroscience, psychopharmacology, and neuroimmunology. Key research applications include:

• Anxiolytic Research: Investigating Selank’s anxiety-reducing effects via GABA-A receptor modulation
• Cognitive Enhancement Studies: Studying Selank’s nootropic effects on learning, memory, and cognitive performance
• Neuroplasticity Research: Examining Selank’s BDNF upregulation and effects on synaptic plasticity
• Enkephalinase Inhibition Studies: Exploring Selank’s inhibition of enkephalin-degrading enzymes
• Neuroimmunology Research: Investigating Selank’s immunomodulatory and anti-inflammatory properties
• Stress Resilience Studies: Preclinical research into Selank’s effects on stress responses and coping mechanisms
• Neuroprotection Research: Studying Selank’s protective effects in models of cerebral ischemia and neural injury
• Neurotransmitter Studies: Exploring Selank’s effects on serotonin, dopamine, and other neurotransmitter systems

Researchers who buy Selank in Switzerland can incorporate this peptide into their experimental protocols across these diverse research areas.

Selank Product Specifications

Specification	Detail
Product Name	Selank
Amount	10mg
Form	Lyophilized powder
Sequence (One-Letter)	TKPRPGP
Sequence (Three-Letter)	Thr-Lys-Pro-Arg-Pro-Gly-Pro
Molecular Formula	C33H57N11O9
Molecular Weight	Approximately 751.87 g/mol
CAS Number	129954-34-3
Source	Synthetic (tuftsin analog)
Mechanism	GABA-A positive allosteric modulator; enkephalinase inhibitor; BDNF upregulator
Research Category	Cognitive & Nootropic Peptides
Purity	≥ 99% (HPLC)
Storage	Store desiccated at -20°C, protected from light

How to Evaluate Selank Quality

When sourcing Selank for research purposes, researchers should consider several quality indicators. A reliable Selank peptide supplier should provide:

• Identity Confirmation: Analytical verification that the peptide matches the expected heptapeptide sequence (Thr-Lys-Pro-Arg-Pro-Gly-Pro, TKPRPGP) and molecular weight (approximately 751.87 g/mol)
• Purity Analysis: Documentation of purity through methods such as HPLC (High-Performance Liquid Chromatography) – Core Peptides provides ≥99% purity
• Batch Information: Clear lot numbers and batch traceability
• Certificate of Analysis (CoA): Documentation of analytical testing results
• Proper Labeling: Accurate product identification and storage instructions
• Appearance: White to off-white lyophilized powder

Researchers looking to buy Selank in Switzerland should seek suppliers who provide comprehensive documentation and quality assurance. Core Peptides remains committed to supporting research with properly documented products.

Understanding the Certificate of Analysis

A Certificate of Analysis (CoA) provides analytical data for a specific batch of a research peptide. For Selank research, a CoA typically includes:

• Identity Confirmation: Mass spectrometry or other analytical methods confirming the peptide’s identity
• Purity Assessment: HPLC chromatograms showing the purity of the peptide
• Batch/Lot Information: Unique identifiers for traceability
• Analytical Methods: Description of the testing methods used

Importantly, researchers should understand that a CoA demonstrates the chemical identity and purity of a peptide but does not establish safety, efficacy, therapeutic effectiveness, or suitability for human use. The CoA serves as a quality control document for research purposes only.

Storage and Stability

Proper storage of research peptides is essential for maintaining their integrity and stability. For Selank, researchers should refer to the product documentation provided with their order for specific storage recommendations.

General best practices for Selank storage include keeping the lyophilized peptide desiccated, protected from light, and stored at -20°C or below. The peptide is soluble in water and buffered aqueous solutions. For specific temperature requirements and reconstitution protocols, consult the applicable product documentation or contact Core Peptides for the applicable storage specifications.

Research Considerations

Researchers incorporating Selank into their studies should be aware of several important considerations:

• Clinical Status: Selank has been studied in human clinical research and has entered clinical practice in Russia as an anxiolytic agent. However, the peptide is supplied for laboratory research purposes only.
• Experimental Status: Researchers consider Selank a well-characterized compound, but findings should be interpreted within the context of ongoing research.
• Model Differences: Results from cell cultures and animal models may not translate directly to human outcomes.
• Regulatory Status: Selank is not FDA-approved and is intended for laboratory research use only.
• Quality Considerations: Researchers should verify the quality and identity of their Selank through appropriate analytical methods.
• Mechanistic Context: Selank’s proposed mechanisms involve GABA-A receptor modulation, enkephalinase inhibition, and BDNF upregulation. Researchers should consider appropriate experimental approaches to investigate these pathways.
• Source Lineage: Selank was developed at the Institute of Molecular Genetics of the Russian Academy of Sciences.

Researchers who buy Selank in Switzerland should ensure their studies include appropriate controls and interpret findings with scientific rigor.

Frequently Asked Questions About Selank

What is Selank?

Selank is a synthetic heptapeptide with the amino acid sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP), developed as an analog of the endogenous immunomodulatory peptide tuftsin.

What is Selank researched for?

Researchers primarily investigate Selank for its anxiolytic (anxiety-reducing) and nootropic (cognitive-enhancing) effects, as well as its neuroplasticity, immunomodulatory, and stress resilience properties.

What is the amino acid sequence of Selank?

The amino acid sequence of Selank is Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP).

What is the molecular weight of Selank?

The molecular weight of Selank is approximately 751.87 g/mol.

What is the CAS number for Selank?

The CAS number for Selank is 129954-34-3.

What is the mechanism of action for Selank?

Selank acts through multiple mechanisms: positive allosteric modulation of GABA-A receptors, inhibition of enkephalin-degrading enzymes, and upregulation of BDNF expression.

Is Selank related to tuftsin?

Yes, Selank is a synthetic analog of tuftsin, a naturally occurring tetrapeptide (Thr-Lys-Pro-Arg) derived from immunoglobulin G.

Does Selank affect BDNF?

Yes, research has shown that Selank increases BDNF expression, which binds to TrkB receptors and supports synaptic plasticity and memory consolidation.

Is Selank FDA-approved?

Selank is not FDA-approved. It is intended for laboratory research use only and is not approved for human consumption or therapeutic use.

Can I buy Selank in Switzerland?

Yes, researchers can buy Selank in Switzerland from Core Peptides for laboratory research purposes.

What is the primary research category for Selank?

Selank belongs to the Cognitive & Nootropic Peptides category, with secondary relevance to Cellular Research & Signaling research.

What related peptides are studied alongside Selank?

Related peptides include tuftsin, Semax, and other nootropic and anxiolytic peptides.

What is the purity of Core Peptides’ Selank?

Core Peptides provides Selank with a purity of ≥99% as verified by HPLC analysis.

How should Selank be stored?

Selank should be stored lyophilized, desiccated, protected from light, at -20°C or below.

Is Selank soluble in water?

Yes, Selank is soluble in water and buffered aqueous solutions.

Related Research Peptides

Researchers interested in Selank may also find the following related peptides relevant to their work:

• Semax – A nootropic peptide developed alongside Selank, studied for cognitive enhancement and neuroprotection
• Tuftsin – The endogenous tetrapeptide from which Selank is derived; studied for immunomodulation
• NA-Semax Amidate – A modified Semax analog with enhanced stability and bioavailability
• Pinealon – A peptide studied for neuroprotection and cognitive function
• Noopept – A dipeptide studied for cognitive enhancement

For a comprehensive selection of research peptides in Switzerland, explore the Core Peptides catalog.

Explore Cognitive & Nootropic Peptides

Selank is part of our Cognitive & Nootropic Peptides category, which features a range of research peptides investigated for their potential effects on cognitive function, neuroplasticity, and brain health. Browse our selection to find the right peptides for your laboratory research.

Explore Related Research Categories

Researchers may also find the following related categories relevant to Selank research:

• Cellular Research & Signaling – Peptides studied for cellular signaling and receptor modulation
• Anti-Aging & Longevity – Peptides investigated for age-related cognitive research applications
• Healing & Regeneration Peptides – Peptides investigated for neuroprotection and tissue repair

Further Research

Researchers interested in learning more about Selank and related peptides should consult the primary scientific literature. Key areas of investigation include GABAergic signaling, enkephalinase inhibition, BDNF regulation, and neuroplasticity. The PubMed database is an excellent resource for accessing peer-reviewed research articles on these topics.

Research Disclaimer

Core Peptides supplies Selank as a research peptide for laboratory research purposes only. It is not approved for human consumption, therapeutic use, or medical treatment. All information provided is for educational and scientific reference purposes only and does not constitute medical advice. Researchers are responsible for ensuring compliance with all applicable laws and regulations governing the use of research peptides in their jurisdiction, including Switzerland.