Cardiogen (20MG)

What Is Cardiogen and Why Buy It for Research?

Buy Cardiogen 20mg in Switzerland for research into tissue-specific gene regulation, cardiac cell biology, and cardioprotective mechanisms. Specifically, Cardiogen (also known as AEDR or Ala-Glu-Asp-Arg) is a synthetic tetrapeptide composed of four amino acids with the sequence Ala-Glu-Asp-Arg (AEDR). It belongs to the Cytogen class of Khavinson peptide bioregulators—short synthetic peptides (2-4 amino acids) developed to regulate gene expression in their target organs through direct interaction with DNA and chromatin.

Khavinson’s team developed Cardiogen in the 1980s and 1990s at the Russian Military Medical Academy after identifying recurring short peptide sequences from heart tissue extracts. Researchers designed the synthetic AEDR tetrapeptide to reproduce the biological activity of these endogenous cardiac peptide fragments. In scientific research, Cardiogen serves as a molecular tool for studying tissue-specific transcriptional regulation in cardiac-derived cell and tissue systems. Furthermore, Core Peptides supplies Cardiogen as a lyophilized powder in a 20mg format exclusively for laboratory use. Therefore, researchers seeking to source this compound for their work will find it readily available when they buy Cardiogen 20mg in Switzerland.

Cardiogen Research Overview: Buy Cardiogen 20mg in Switzerland for Cardiac Gene Expression Studies

Centrally, research into Cardiogen has focused on its function as a tissue-specific bioregulator targeting cardiac tissue. Endogenously, cardiomyocytes play a critical role in maintaining cardiac function through contractile protein synthesis, calcium handling, and oxidative stress defense. Researchers designed Cardiogen based on amino acid analysis of polypeptide extracts from heart tissue, with the aim of restoring and maintaining normal function of cardiac cells.

Unlike conventional pharmaceutical agents that act through receptor-mediated signaling (GPCRs), Khavinson’s bioregulator theory proposes that AEDR penetrates cell nuclei and interacts directly with DNA at specific sequence motifs and with histone proteins, thereby modulating transcription of tissue-relevant genes. In vitro studies have demonstrated that Cardiogen interacts with DNA, strongly quenching fluorescence of methylated and unmethylated λ phage DNA-ethidium bromide complexes. Researchers believe this direct nuclear interaction increases transcriptional availability at cardiac-specific gene promoter regions, enabling expression of genes involved in myocardial differentiation and maintenance. Accordingly, researchers who buy Cardiogen 20mg in Switzerland from Core Peptides can support their investigations into peptide-DNA interactions, gene expression regulation, and cardiac biology.

How Does Cardiogen Work in Research?

Mechanistically, Cardiogen’s proposed action involves functioning as a nuclear-targeting peptide that modulates gene expression in cardiac cells through direct DNA and histone interactions. The peptide binds to histones H1, H2b, H3, and H4 at its N-terminal peptide-binding motif. Researchers believe this interaction increases the transcriptional availability of cardiac-specific gene promoter regions.

For example, a 2012 study published in the Bulletin of Experimental Biology and Medicine demonstrated that the tetrapeptide H-Ala-Glu-Asp-Arg-OH enhances the expression of cytoskeletal proteins (actin, tubulin, vimentin) by 2 to 5 times and nuclear matrix proteins (lamin A, lamin C) by 2 to 3 times in cultured mouse embryonic fibroblasts. Consequently, the study concluded that the previously reported cardioprotective activity of this tetrapeptide depends on its capacity to activate synthesis of cytoskeletal and nuclear matrix proteins, which stimulates cell proliferation and reduces apoptosis.

Furthermore, in organotypic myocardial tissue culture studies by Chalisova et al. (2009), Cardiogen uniquely stimulated cardiomyocyte proliferation at picomolar concentrations (10⁻¹² M) in tissue from both young (3-month-old) and aged (24-month-old) rats. Critically, the same concentration of any individual natural amino acid failed to reproduce this effect, confirming that the biological activity resides in the intact tetrapeptide sequence rather than its constituent amino acids. Immunohistochemical analysis revealed that Cardiogen reduced p53 tumor suppressor protein expression in myocardial tissue, indicating suppression of apoptotic pathways. This dual action—stimulating proliferation while inhibiting programmed cell death—is particularly significant for cardiac biology, where cardiomyocyte loss through apoptosis is a hallmark of aging and ischemic heart disease.

Why Is Cardiogen Studied in Switzerland?

Primarily, researchers study Cardiogen because it represents a well-characterized tetrapeptide bioregulator that enables investigation of tissue-specific gene expression, DNA interaction, and cardiac cell biology. In fact, this compound offers a focused tool for studying the molecular mechanisms underlying cardiomyocyte function, apoptosis regulation, and cytoprotective signaling.

Research has demonstrated Cardiogen’s effects across multiple domains. In organotypic tissue culture, Cardiogen showed a stimulating effect in heart tissue explants from both young and aged rats. Moreover, researchers have studied the peptide for its ability to modulate gene expression programs in cardiomyocyte and cardiac-fibroblast models, including transcripts associated with contractile proteins, calcium handling, and oxidative stress defense. Additionally, investigators have examined Cardiogen for its effects on chromatin activation and its potential role in modulating age-related cardiac decline. Ultimately, researchers who buy Cardiogen 20mg in Switzerland gain access to a research tool that may help uncover mechanisms underlying cardiac function, myocardial protection, and tissue-specific gene regulation.

Cardiogen Research Areas in Laboratory Studies

Research Area	Focus	Evidence Level
Gene Expression Regulation	Cardiac-specific gene transcription, promoter activity modulation	Mechanistic / In Vitro
DNA and Chromatin Interaction	Peptide-DNA binding, histone interaction, chromatin conformation	Mechanistic
Cardiomyocyte Proliferation	Cell cycle activation, myocardial regeneration, tissue growth	Ex Vivo / Preclinical
Apoptosis Regulation	p53 suppression, anti-apoptotic signaling, cell survival	Mechanistic / Ex Vivo
Cytoskeletal Protein Synthesis	Actin, tubulin, vimentin expression, cellular structure	Mechanistic / In Vitro
Nuclear Matrix Protein Synthesis	Lamin A, lamin C expression, nuclear integrity	Mechanistic / In Vitro
Cardiac Aging Research	Age-related functional decline, cellular senescence	Preclinical
Cardioprotection	Ischemic injury, oxidative stress, myocardial protection	Preclinical

Cardiogen Compared With Related Research Compounds

Compound	Research Focus	Mechanism / Target	Key Difference
Cardiogen (AEDR)	Cardiac tissue, cardiomyocyte function	DNA interaction, chromatin modulation, gene expression	Tetrapeptide; heart tissue-specific bioregulator
Epitalon (AEDG)	Pineal gland, aging, circadian rhythms	DNA interaction, telomerase activation	Different target tissue; Ala-Glu-Asp-Gly sequence
Bronchogen (AEDL)	Bronchial epithelium, pulmonary research	DNA interaction, gene expression modulation	Different target tissue; Ala-Glu-Asp-Leu sequence
Cortagen (AEDP)	Nervous system, brain	DNA interaction, neuroprotection	Different target tissue; Ala-Glu-Asp-Pro sequence

Comparatively, Cardiogen differs from other Khavinson peptide bioregulators in its tissue specificity and amino acid sequence. On the one hand, Epitalon (Ala-Glu-Asp-Gly) targets pineal gland function and aging-related processes, while Bronchogen (Ala-Glu-Asp-Leu) focuses on bronchial and pulmonary tissue. On the other hand, Cardiogen (Ala-Glu-Asp-Arg) is specifically designed for cardiac tissue research, with demonstrated effects on cardiomyocyte proliferation, cytoskeletal protein synthesis, and apoptosis suppression. In contrast, Cortagen (Ala-Glu-Asp-Pro) targets nervous system tissues.

Research Applications for Cardiogen in Switzerland

Scientists have investigated Cardiogen across several research domains:

• Gene Expression Studies: Researchers use Cardiogen to investigate tissue-specific gene regulation in cardiomyocyte and cardiac-fibroblast cultures, including transcripts associated with contractile proteins, calcium handling, and oxidative stress defense.
• DNA and Chromatin Interaction Research: The peptide serves as a probe for studying short peptide-DNA promoter interactions, histone binding, and chromatin remodeling.
• Cardiomyocyte Proliferation Studies: Organotypic tissue culture models have examined Cardiogen’s effects on cardiomyocyte proliferation at picomolar concentrations in both young and aged tissue.
• Apoptosis and Cell Survival Research: Investigations have explored Cardiogen’s role in p53 suppression and anti-apoptotic signaling in cardiac cells.
• Cytoskeletal and Nuclear Matrix Research: Studies have demonstrated Cardiogen’s capacity to enhance expression of actin, tubulin, vimentin, lamin A, and lamin C.
• Cardiac Aging Models: Preclinical research has examined Cardiogen’s effects on age-related cardiac function decline and cellular senescence.

Evidently, researchers who buy Cardiogen 20mg in Switzerland gain a valuable addition to any laboratory toolkit focused on cardiac biology, gene regulation, and tissue-specific peptide research.

Cardiogen Product Specifications

Specification	Details
Product Name	Cardiogen (AEDR)
Alternative Names	AEDR, Ala-Glu-Asp-Arg, Cardiogen peptide bioregulator, Cytogen class peptide
Amount	20mg
Form	Lyophilized powder (white to off-white)
Purity	Not verified (≥98.5% to ≥99% reported by some suppliers)
Amino Acid Sequence	H-Ala-Glu-Asp-Arg-OH (AEDR)
Sequence (3-letter)	Ala-Glu-Asp-Arg
Peptide Length	4 amino acids (tetrapeptide)
Molecular Formula	C₁₈H₃₁N₇O₉
Molecular Weight	489.48 g/mol
CAS Number	857267-11-9
Research Category	Healing & Regeneration / Anti-Aging & Longevity
Research Use	Laboratory research use only
CoA	Available upon request (not verified)
Storage	Lyophilized powder should be stored desiccated at -20°C or below, protected from light
Solubility	Soluble in water and buffered aqueous solutions

How to Evaluate Cardiogen Quality for Research

When sourcing Cardiogen peptide for laboratory research, researchers should consider several quality indicators:

• Identity Confirmation: Analytical techniques such as mass spectrometry should confirm the compound’s molecular weight (489.48 g/mol) and sequence (H-Ala-Glu-Asp-Arg-OH).
• Purity Assessment: High-performance liquid chromatography (HPLC) should verify purity, with ≥98% considered standard for research-grade material.
• Batch Traceability: Lot numbers and batch information enable researchers to track specific production runs.
• Certificate of Analysis: A CoA should accompany the product, detailing analytical testing results including HPLC purity and identity confirmation.
• Labeling Accuracy: Proper labeling should clearly indicate the product name, amount (20mg), sequence, molecular formula, CAS number, and storage recommendations.
• Storage Conditions: Appropriate storage at -20°C or below in desiccated, dark conditions helps maintain peptide stability.

Understanding the Certificate of Analysis

Typically, a Certificate of Analysis (CoA) accompanies research peptides and provides information about the specific batch’s analytical testing. For example, a CoA may include product identity confirmation, purity percentage as determined by HPLC, batch or lot number for traceability, analytical methods used (e.g., mass spectrometry, HPLC), and a physical description of the product.

Nevertheless, it is important to note that a CoA does not establish safety, efficacy, therapeutic effectiveness, or suitability for human use. Instead, it serves as a quality control document that helps researchers verify the identity and purity of the peptide they are using in their laboratory investigations.

Storage and Stability of Cardiogen

Core Peptides supplies Cardiogen as a lyophilized (freeze-dried) powder. To maintain stability and integrity:

• Store the lyophilized powder desiccated at -20°C or below for long-term storage
• Store at 4°C for short-term storage if frequent access is required
• Avoid repeated freeze-thaw cycles
• Weigh under dry conditions; the peptide is hygroscopic
• Reconstitute only immediately before use with appropriate sterile solvents (sterile water or buffered aqueous solutions)
• Inject solvent slowly against the inner wall of the vial; avoid vigorous agitation during dissolution
• Filter sterilize if required (e.g., 0.22 µm) immediately prior to use
• Aliquot and store reconstituted solutions at -20°C or below to minimize degradation
• Protect from light and moisture; prolonged exposure to light, elevated temperature, or aqueous environments may reduce stability

Frequently Asked Questions About Buying Cardiogen 20mg in Switzerland

What is Cardiogen?

Specifically, Cardiogen (AEDR) is a synthetic tetrapeptide with the amino acid sequence Ala-Glu-Asp-Arg (AEDR). It is a tissue-specific bioregulator developed by Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology as a cardiac-specific bioregulator.

What is Cardiogen researched for?

Primarily, researchers study Cardiogen for its role in cardiac tissue gene expression regulation, cardiomyocyte proliferation, and apoptosis suppression. Studies have investigated its effects on cytoskeletal protein synthesis, nuclear matrix protein expression, and cardioprotective mechanisms.

How does Cardiogen work?

Mechanistically, Cardiogen functions as a nuclear-targeting peptide that penetrates cell nuclei and interacts directly with DNA and histone proteins, thereby modulating transcription of tissue-relevant genes in cardiac cells. It enhances expression of cytoskeletal proteins (actin, tubulin, vimentin) and nuclear matrix proteins (lamin A, lamin C).

What is the amino acid sequence of Cardiogen?

The amino acid sequence is H-Ala-Glu-Asp-Arg-OH (AEDR).

What is the molecular weight of Cardiogen?

The molecular weight is 489.48 g/mol.

What is the molecular formula of Cardiogen?

The molecular formula is C₁₈H₃₁N₇O₉.

What is the CAS number of Cardiogen?

The CAS number is 857267-11-9.

Is Cardiogen synthetic?

Yes, Cardiogen is a synthetic peptide produced through solid-phase peptide synthesis.

What research exists on Cardiogen?

Research on Cardiogen includes a 2009 organotypic tissue culture study demonstrating cardiomyocyte proliferation at picomolar concentrations, a 2012 study showing enhanced expression of cytoskeletal and nuclear matrix proteins, and investigations into peptide-DNA interactions and chromatin modulation.

Is Cardiogen approved as a medicine?

No. Regulatory authorities have not approved Cardiogen as a medicine, pharmaceutical, or therapeutic agent. All published research is preclinical; no human clinical trials have been conducted.

Is Cardiogen intended for human use?

No. Cardiogen is intended for laboratory research use only and is not for human consumption, injection, or therapeutic application.

Where can I buy Cardiogen 20mg in Switzerland?

You can buy Cardiogen 20mg in Switzerland from Core Peptides, a trusted research peptide supplier serving the Swiss scientific community.

How should researchers evaluate Cardiogen quality?

Researchers should look for identity confirmation via mass spectrometry, purity data from HPLC, batch traceability, and a Certificate of Analysis.

Related Research Compounds

Researchers interested in Cardiogen may also find the following related compounds relevant to their work:

• Epitalon — A related Khavinson tetrapeptide (Ala-Glu-Asp-Gly) researched for pineal gland function, aging, and telomerase activation.
• Bronchogen — A related Khavinson tetrapeptide (Ala-Glu-Asp-Leu) researched for bronchial epithelium and pulmonary tissue.
• Cortagen — A related Khavinson tetrapeptide (Ala-Glu-Asp-Pro) researched for nervous system tissue and neuroprotection.
• BPC-157 — A peptide researched for tissue healing, gastrointestinal protection, and angiogenesis.

Explore Healing & Regeneration

Cardiogen belongs to the Healing & Regeneration category of research compounds. Healing & Regeneration products are studied for their potential roles in tissue repair, cellular regeneration, and cytoprotective mechanisms. Generally, researchers who buy Cardiogen 20mg in Switzerland often pair it with related compounds in this category to explore complementary pathways in cardiac repair and regenerative research.

Explore Anti-Aging & Longevity

Researchers studying age-related cardiac decline, cellular senescence, and tissue-specific bioregulation may also find relevant compounds in the Anti-Aging & Longevity category. Cardiogen’s effects on cardiomyocyte proliferation and apoptosis suppression in aged tissue models make it a valuable tool for investigating cardiac aging and regenerative biology.

Further Research

For researchers seeking to deepen their understanding of Cardiogen and its research applications, the following areas may warrant further investigation:

• The relationship between Cardiogen-mediated DNA interaction and specific downstream gene expression changes in cardiomyocytes and cardiac fibroblasts
• Comparative studies between Cardiogen and other Khavinson peptides in various cardiac and tissue-specific models
• The potential role of Cardiogen in modulating age-related cardiac function decline and cellular senescence
• Mechanistic studies on Cardiogen’s interaction with histones and chromatin and its functional consequences for gene transcription
• Exploration of Cardiogen’s effects on different cell types and tissue systems beyond cardiac tissue

Research Disclaimer

Cardiogen is a research peptide supplied for laboratory research use only. Researchers must not use it for human consumption, injection, or any form of therapeutic application. Moreover, this product is not a medicine, pharmaceutical, or medical device. Furthermore, Swissmedic, the FDA, EMA, or any other regulatory authority have not approved it for human use. Researchers should consult Swissmedic for applicable regulations and guidance on research peptide handling in Switzerland.

Generally, the information provided on this page is for educational and scientific reference purposes only. Therefore, it does not constitute medical advice, treatment recommendations, or dosing instructions. Ultimately, researchers bear the responsibility for ensuring that their use of this product complies with all applicable laws, regulations, and institutional guidelines.

Finally, all research involving peptides should be conducted by qualified personnel in appropriate laboratory settings with proper safety protocols.