Chonluten (20MG)

What Is Chonluten and Why Buy It for Research?

Buy Chonluten 20mg in Switzerland for research into respiratory epithelium biology, anti-inflammatory pathways, and tissue-specific gene regulation. Specifically, Chonluten (also known as EDG, T-34, or Glu-Asp-Gly) is a synthetic tripeptide composed of three amino acids with the sequence Glu-Asp-Gly (EDG). Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology developed Chonluten as a respiratory system bioregulator derived from analysis of bronchial mucosal tissue extracts.

In scientific research, Chonluten serves as a molecular tool for studying tissue-specific gene expression regulation in respiratory epithelial and mucosal experimental systems. Researchers consider this peptide particularly valuable for investigating stress-response pathways, antioxidant defense mechanisms, and inflammatory signaling in bronchial epithelium models. Furthermore, Core Peptides supplies Chonluten as a lyophilized powder in a 20mg format exclusively for laboratory use. Therefore, researchers seeking to source this compound for their work will find it readily available when they buy Chonluten 20mg in Switzerland.

Chonluten Research Overview: Buy Chonluten 20mg in Switzerland for Respiratory Studies

Centrally, research into Chonluten has focused on its function as a tissue-specific bioregulator targeting respiratory epithelium and mucosal tissues. Researchers identified the peptide through amino acid analysis of bronchial mucosal tissue extracts, where the EDG sequence appeared as a recurring motif. Unlike the AED-based Khavinson peptides (Cartalax, Bronchogen, Cardiogen, Epithalon), Chonluten has a distinct amino acid composition beginning with glutamic acid and ending with glycine. This structural difference reflects its different tissue derivation (bronchial mucosa rather than organ parenchyma) and distinct gene expression targets.

Chonluten is often paired with Bronchogen (AEDL) in the Khavinson bioregulator system, as the two peptides target overlapping but complementary pathways in bronchial tissue. While Bronchogen primarily regulates differentiation and mucin genes (NKX2-1, MUC4, MUC5AC), Chonluten focuses on stress-protective pathways including heat shock proteins, antioxidant enzymes, and inflammatory mediators. Accordingly, researchers who buy Chonluten 20mg in Switzerland from Core Peptides can support their investigations into peptide-DNA interactions, respiratory biology, and anti-inflammatory mechanisms.

How Does Chonluten Work in Research?

Mechanistically, Chonluten’s proposed action involves functioning as a nuclear-targeting peptide that modulates gene expression in respiratory epithelial cells through multiple interconnected protective mechanisms.

Stress-Response Gene Regulation: The most extensively characterized mechanism involves regulation of cellular stress-response genes. In bronchial epithelial cell cultures, EDG modulates expression of c-Fos, an immediate-early gene and component of the AP-1 transcription factor complex involved in cellular stress response, proliferation, and differentiation. Additionally, Chonluten regulates HSP70, a molecular chaperone that protects proteins from stress-induced denaturation and facilitates cellular recovery from thermal, oxidative, and chemical stress.

Antioxidant Enzyme Modulation: Chonluten regulates expression of superoxide dismutase (SOD), a key antioxidant enzyme that protects cells from oxidative damage. Through such modulation, it may tilt the redox balance toward a more reduced microenvironment, indirectly influencing cell survival, repair, and proliferation pathways.

Anti-Inflammatory Activity: Research demonstrates that Chonluten functions as an anti-inflammatory agent that modulates immune cell activity and cytokine production. Studies show the peptide inhibits tumor necrosis factor (TNF) production in monocytes and reduces pro-inflammatory cytokines IL-6 and IL-17. The Chonluten tripeptide, derived from bronchial epithelial cells, inhibited in vitro tumor necrosis factor (TNF) production of monocytes exposed to pro-inflammatory bacterial lipopolysaccharide (LPS). Chonluten activates STAT1 signaling pathways and induces TNF tolerance in macrophages, promoting resolution of inflammatory responses.

Epithelial Barrier Protection: Research indicates Chonluten specifically targets epithelial cells and promotes the expression and proper assembly of key proteins within tight junctions. Strengthening these structural junctions significantly reduces epithelial permeability, effectively blocking trans-epithelial penetration of pathogens, allergens, and harmful substances. Simultaneously, epithelial cell migration and proliferation are stimulated, aiding in the more rapid repair of mucosal barriers.

Why Is Chonluten Studied in Switzerland?

Primarily, researchers study Chonluten because it represents a well-characterized tripeptide bioregulator that enables investigation of respiratory-specific gene expression, anti-inflammatory pathways, and mucosal protection. In fact, this compound offers a focused tool for studying the molecular mechanisms underlying respiratory epithelium function, oxidative stress defense, and tissue repair.

Research has demonstrated Chonluten’s effects across multiple domains. In bronchial epithelial cell cultures, Chonluten modulates stress-response genes and antioxidant enzymes. Studies show that Chonluten inhibits TNF production in monocytes and reduces pro-inflammatory cytokines. Additionally, researchers have investigated Chonluten for its effects on epithelial barrier integrity and mucosal protection. The peptide has demonstrated potential in respiratory research models, including chronic bronchitis and COPD. Ultimately, researchers who buy Chonluten 20mg in Switzerland gain access to a research tool that may help uncover mechanisms underlying respiratory biology, inflammation, and tissue-specific gene regulation.

Chonluten Research Areas in Laboratory Studies

Research Area	Focus	Evidence Level
Stress-Response Gene Regulation	c-Fos, HSP70 modulation, cellular stress response	Mechanistic / In Vitro
Antioxidant Defense	SOD expression, redox balance, oxidative stress protection	Mechanistic / In Vitro
Anti-Inflammatory Signaling	TNF-α inhibition, IL-6, IL-17 reduction, STAT1 activation	Mechanistic / In Vitro
Epithelial Barrier Function	Tight junction proteins, epithelial permeability, mucosal integrity	Mechanistic / In Vitro
Respiratory Epithelium Research	Bronchial epithelial cell models, mucosal tissue, airway research	In Vitro / Preclinical
Immune Cell Modulation	Monocyte TNF tolerance, macrophage function, cytokine regulation	Mechanistic / In Vitro
COPD and Chronic Bronchitis Models	Respiratory inflammation, mucosal protection, tissue repair	Preclinical

Chonluten Compared With Related Research Compounds

Compound	Research Focus	Mechanism / Target	Key Difference
Chonluten (EDG)	Respiratory epithelium, anti-inflammatory, mucosal protection	Stress-response genes, antioxidant enzymes, TNF inhibition	Tripeptide; Glu-Asp-Gly sequence; respiratory-specific
Bronchogen (AEDL)	Bronchial epithelium, pulmonary research	DNA interaction, gene expression modulation, mucin genes	Different sequence; Ala-Glu-Asp-Leu; complementary target
Epitalon (AEDG)	Pineal gland, aging, circadian rhythms	DNA interaction, telomerase activation	Different target tissue; Ala-Glu-Asp-Gly sequence
Cartalax (AED)	Cartilage, connective tissue, chondrocytes	DNA interaction, gene expression modulation	Different target tissue; cartilage-specific bioregulator

Comparatively, Chonluten differs from other Khavinson peptide bioregulators in its tissue specificity and amino acid sequence. On the one hand, Bronchogen (Ala-Glu-Asp-Leu) targets overlapping but complementary pathways in bronchial tissue, primarily regulating differentiation and mucin genes. On the other hand, Chonluten (Glu-Asp-Gly) focuses on stress-protective pathways including heat shock proteins, antioxidant enzymes, and inflammatory mediators. In contrast, Epitalon targets pineal gland function while Cartalax focuses on cartilage and connective tissue.

Research Applications for Chonluten in Switzerland

Scientists have investigated Chonluten across several research domains:

• Respiratory Epithelium Research: Researchers use Chonluten to investigate bronchial epithelial cell function, stress-response gene regulation, and mucosal integrity in respiratory models.
• Anti-Inflammatory Studies: The peptide serves as a tool for studying TNF-alpha inhibition, IL-6 and IL-17 reduction, and STAT1 signaling pathways in immune cell models.
• Oxidative Stress Research: Investigations have explored Chonluten’s effects on antioxidant enzyme modulation, including superoxide dismutase (SOD) expression.
• Epithelial Barrier Function: Studies have examined Chonluten’s role in tight junction protein expression, epithelial permeability reduction, and mucosal barrier protection.
• Immune Cell Modulation: Research has investigated Chonluten’s effects on monocyte TNF production, macrophage function, and cytokine regulation.
• Respiratory Disease Models: Preclinical research has examined Chonluten’s potential in chronic bronchitis and COPD models.

Evidently, researchers who buy Chonluten 20mg in Switzerland gain a valuable addition to any laboratory toolkit focused on respiratory biology, anti-inflammatory research, and tissue-specific peptide bioregulation.

Chonluten Product Specifications

Specification	Details
Product Name	Chonluten (EDG)
Alternative Names	EDG, T-34, Glu-Asp-Gly, Honluten, Chonluten peptide bioregulator
Amount	20mg
Form	Lyophilized powder (white to off-white)
Purity	Not verified (≥98-99% HPLC purity reported by some suppliers)
Amino Acid Sequence	H-Glu-Asp-Gly-OH (EDG)
Sequence (3-letter)	Glu-Asp-Gly
Peptide Length	3 amino acids (tripeptide)
Molecular Formula	C₁₁H₁₇N₃O₈
Molecular Weight	319.27 g/mol
CAS Number	Not available
Research Category	Immunity & Inflammation / Healing & Regeneration
Research Use	Laboratory research use only
CoA	Available upon request (not verified)
Storage	Lyophilized powder should be stored desiccated at -20°C or below, protected from light
Solubility	Soluble in water and buffered aqueous solutions

How to Evaluate Chonluten Quality for Research

When sourcing Chonluten peptide for laboratory research, researchers should consider several quality indicators:

• Identity Confirmation: Analytical techniques such as mass spectrometry should confirm the compound’s molecular weight (319.27 g/mol) and sequence (H-Glu-Asp-Gly-OH).
• Purity Assessment: High-performance liquid chromatography (HPLC) should verify purity, with ≥98% considered standard for research-grade material.
• Batch Traceability: Lot numbers and batch information enable researchers to track specific production runs.
• Certificate of Analysis: A CoA should accompany the product, detailing analytical testing results including HPLC purity and identity confirmation.
• Labeling Accuracy: Proper labeling should clearly indicate the product name, amount (20mg), sequence, molecular formula, and storage recommendations.
• Storage Conditions: Appropriate storage at -20°C or below in desiccated, dark conditions helps maintain peptide stability.

Understanding the Certificate of Analysis

Typically, a Certificate of Analysis (CoA) accompanies research peptides and provides information about the specific batch’s analytical testing. For example, a CoA may include product identity confirmation, purity percentage as determined by HPLC, batch or lot number for traceability, analytical methods used (e.g., mass spectrometry, HPLC), and a physical description of the product.

Nevertheless, it is important to note that a CoA does not establish safety, efficacy, therapeutic effectiveness, or suitability for human use. Instead, it serves as a quality control document that helps researchers verify the identity and purity of the peptide they are using in their laboratory investigations.

Storage and Stability of Chonluten

Core Peptides supplies Chonluten as a lyophilized (freeze-dried) powder. To maintain stability and integrity:

• Store the lyophilized powder desiccated at -20°C or below for long-term storage
• Store at 4°C for short-term storage if frequent access is required
• Avoid repeated freeze-thaw cycles
• Weigh under dry conditions; the peptide is hygroscopic
• Reconstitute only immediately before use with appropriate sterile solvents (sterile water or buffered aqueous solutions)
• Inject solvent slowly against the inner wall of the vial; avoid vigorous agitation during dissolution
• Filter sterilize if required (e.g., 0.22 µm) immediately prior to use
• Aliquot and store reconstituted solutions at -20°C or below to minimize degradation
• Protect from light and moisture; prolonged exposure to light, elevated temperature, or aqueous environments may reduce stability

Frequently Asked Questions About Buying Chonluten 20mg in Switzerland

What is Chonluten?

Specifically, Chonluten (EDG, T-34) is a synthetic tripeptide with the amino acid sequence Glu-Asp-Gly (EDG). It is a tissue-specific bioregulator developed by Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology as a respiratory system bioregulator.

What is Chonluten researched for?

Primarily, researchers study Chonluten for its role in respiratory epithelium function, anti-inflammatory pathways, and mucosal protection. Studies have investigated its effects on stress-response gene regulation, antioxidant enzyme modulation, TNF-alpha inhibition, and epithelial barrier function.

How does Chonluten work?

Mechanistically, Chonluten functions through multiple interconnected protective mechanisms: stress-response gene regulation (c-Fos, HSP70), antioxidant enzyme modulation (SOD), anti-inflammatory activity (TNF-alpha inhibition, IL-6 and IL-17 reduction), and epithelial barrier protection (tight junction proteins).

What is the amino acid sequence of Chonluten?

The amino acid sequence is H-Glu-Asp-Gly-OH (EDG).

What is the molecular weight of Chonluten?

The molecular weight is 319.27 g/mol.

What is the molecular formula of Chonluten?

The molecular formula is C₁₁H₁₇N₃O₈.

Is Chonluten synthetic?

Yes, Chonluten is a synthetic peptide produced through solid-phase peptide synthesis.

How does Chonluten differ from Bronchogen?

Chonluten (Glu-Asp-Gly) and Bronchogen (Ala-Glu-Asp-Leu) target overlapping but complementary pathways in bronchial tissue. Bronchogen primarily regulates differentiation and mucin genes, while Chonluten focuses on stress-protective pathways including heat shock proteins, antioxidant enzymes, and inflammatory mediators.

What research exists on Chonluten?

Research on Chonluten includes in vitro studies demonstrating TNF inhibition in monocytes exposed to LPS, studies on stress-response gene regulation and antioxidant enzyme modulation in bronchial epithelial cells, and preclinical research in respiratory models including chronic bronchitis and COPD. Limited clinical observational data exists from Russian studies.

Is Chonluten approved as a medicine?

No. Regulatory authorities have not approved Chonluten as a medicine, pharmaceutical, or therapeutic agent. All published research is primarily preclinical with limited clinical data.

Is Chonluten intended for human use?

No. Chonluten is intended for laboratory research use only and is not for human consumption, injection, or therapeutic application.

Where can I buy Chonluten 20mg in Switzerland?

You can buy Chonluten 20mg in Switzerland from Core Peptides, a trusted research peptide supplier serving the Swiss scientific community.

How should researchers evaluate Chonluten quality?

Researchers should look for identity confirmation via mass spectrometry, purity data from HPLC, batch traceability, and a Certificate of Analysis.

Related Research Compounds

Researchers interested in Chonluten may also find the following related compounds relevant to their work:

• Bronchogen — A related Khavinson tetrapeptide (Ala-Glu-Asp-Leu) researched for bronchial epithelium and pulmonary tissue, complementary to Chonluten.
• Epitalon — A related Khavinson tetrapeptide (Ala-Glu-Asp-Gly) researched for pineal gland function, aging, and telomerase activation.
• Cartalax — A related Khavinson tripeptide (Ala-Glu-Asp) researched for cartilage and connective tissue.
• Cardiogen — A related Khavinson tetrapeptide (Ala-Glu-Asp-Arg) researched for cardiac tissue and cardiomyocyte function.

Explore Immunity & Inflammation

Chonluten belongs to the Immunity & Inflammation category of research compounds. Immunity & Inflammation products are studied for their potential roles in inflammatory signaling, immune modulation, and tissue protection. Generally, researchers who buy Chonluten 20mg in Switzerland often pair it with related compounds in this category to explore complementary pathways in respiratory inflammation and mucosal protection research.

Explore Healing & Regeneration

Researchers studying tissue repair, epithelial regeneration, and mucosal protection may also find relevant compounds in the Healing & Regeneration category. Chonluten’s effects on epithelial barrier function and mucosal repair make it a valuable tool for investigating respiratory recovery and regenerative biology.

Further Research

For researchers seeking to deepen their understanding of Chonluten and its research applications, the following areas may warrant further investigation:

• The relationship between Chonluten-mediated stress-response gene regulation and specific downstream anti-inflammatory pathways in bronchial epithelial cells
• Comparative studies between Chonluten and Bronchogen in various respiratory and tissue-specific models
• The potential role of Chonluten in modulating epithelial barrier function and tight junction protein expression
• Mechanistic studies on Chonluten’s interaction with DNA and its functional consequences for gene transcription
• Exploration of Chonluten’s effects on different cell types and tissue systems beyond respiratory epithelium

Research Disclaimer

Chonluten is a research peptide supplied for laboratory research use only. Researchers must not use it for human consumption, injection, or any form of therapeutic application. Moreover, this product is not a medicine, pharmaceutical, or medical device. Furthermore, Swissmedic, the FDA, EMA, or any other regulatory authority have not approved it for human use. Researchers should consult Swissmedic for applicable regulations and guidance on research peptide handling in Switzerland.

Generally, the information provided on this page is for educational and scientific reference purposes only. Therefore, it does not constitute medical advice, treatment recommendations, or dosing instructions. Ultimately, researchers bear the responsibility for ensuring that their use of this product complies with all applicable laws, regulations, and institutional guidelines.

Finally, all research involving peptides should be conducted by qualified personnel in appropriate laboratory settings with proper safety protocols.