Ovagen (20MG)

What Is Ovagen?

Ovagen is a synthetic tripeptide with the amino acid sequence Glu-Asp-Leu (EDL) and a molecular weight of approximately 375.37 g/mol (molecular formula C₁₅H₂₅N₃O₈). Vladimir Khavinson and his colleagues at the St. Petersburg Institute of Bioregulation and Gerontology developed this compound within a broader research framework. Notably, Ovagen belongs to a class of ultrashort peptide bioregulators. Scientists specifically design these peptides to investigate organ-specific function restoration through epigenetic modulation of gene expression. Furthermore, researchers derived Ovagen from liver tissue extracts. They primarily investigate its effects on hepatic and gastrointestinal tissue. Consequently, researchers who buy Ovagen in Switzerland gain access to a well-characterized research tool for exploring tissue-specific gene regulation and cellular signaling pathways.

Ovagen Research Overview

Several investigations have examined Ovagen research peptide’s biological activity in liver and gastrointestinal experimental systems. As a member of the Khavinson bioregulator family, Ovagen demonstrates a proposed ability to enter cells and act at the chromatin level. Specifically, researchers study how it modulates the expression of genes associated with hepatocyte proliferation and epithelial homeostasis.

The research surrounding Ovagen in Switzerland focuses primarily on in-vitro and preclinical models. For instance, studies have examined its effects on proliferation and apoptosis markers, including Ki-67 and p53, in cell cultures derived from both young and aged tissue. Moreover, researchers have reported that Ovagen may increase expression of the proliferation marker Ki-67 while decreasing expression of apoptosis and senescence markers including p53, p16, and p21.

Nevertheless, the research base for Ovagen originates primarily from publications by Khavinson’s group and affiliated institutions. Accordingly, no human clinical trials have been registered or published for this compound. Furthermore, independent replication of its biological effects by external laboratories remains limited.

How Does Ovagen Work?

The proposed mechanism of Ovagen involves epigenetic regulation of gene expression. According to the Khavinson bioregulator theory, ultrashort peptides of 2–7 amino acids can penetrate cell membranes and nuclear membranes. Subsequently, they interact directly with double-stranded DNA and histone proteins.

Researchers believe Ovagen acts as a molecular probe for investigating tissue-specific effects on hepatic and gastrointestinal epithelial signaling. In experimental models, it modulates expression of genes associated with hepatocyte proliferation and epithelial homeostasis within the Khavinson « peptide regulation of gene expression » framework. Conversely, observed effects depend on concentration, model system, and exposure conditions.

Thus, cell culture studies have shown that Ovagen may influence cellular aging markers. Furthermore, researchers have observed these effects in both young and aged cell cultures. Moreover, the peptide appears to increase expression of the longevity-associated sirtuin SIRT-6 in addition to modulating proliferation and apoptosis markers.

Why Is Ovagen Studied?

Researchers study Ovagen primarily for its potential role in hepatic and gastrointestinal tissue research. Accordingly, scientists investigating liver function, GI mucosal health, and digestive tissue repair have shown considerable interest in this peptide bioregulator.

Key research interests include:

• Hepatic gene expression modulation — Investigating how short peptides may influence liver cell function at the transcriptional level
• Hepatocyte regeneration support — Exploring potential effects on liver cell regeneration and metabolic activity
• Gastrointestinal epithelial homeostasis — Examining tissue-specific effects on GI epithelial signaling
• Cellular aging markers — Studying the modulation of proliferation, apoptosis, and senescence markers in aged versus young tissue
• Peptide bioregulation mechanisms — Understanding how ultrashort peptides may interact with DNA and chromatin to regulate gene expression

Therefore, researchers who buy Ovagen in Switzerland for laboratory studies contribute to the growing body of knowledge surrounding peptide bioregulation and tissue-specific gene regulation.

Ovagen Research Areas

Research Area	Description	Evidence Level
Hepatic Gene Expression	Investigation of liver cell gene regulation and transcriptional modulation	Preclinical / In Vitro
Gastrointestinal Epithelial Signaling	Study of GI tissue homeostasis and epithelial cell function	Preclinical / In Vitro
Cellular Aging & Senescence	Examination of proliferation (Ki-67) and apoptosis (p53, p16, p21) markers	In Vitro
Hepatocyte Regeneration	Research into liver cell regeneration and metabolic enzyme expression	Preclinical
Peptide-DNA Interaction	Investigation of direct peptide binding to DNA and histone proteins	Mechanistic / Theoretical
Longevity & SIRT-6 Modulation	Study of sirtuin expression and potential longevity-associated pathways	In Vitro

Ovagen Compared With Related Peptides

Compound	Research Focus	Mechanism / Target	Key Difference
Ovagen (EDL)	Liver & GI tissue research	Epigenetic gene regulation; hepatic/GI signaling	Tripeptide (Glu-Asp-Leu); liver/GI-specific
Livagen (KEDA)	Liver research	Peptide bioregulation; hepatic function	Different amino acid sequence; similar organ target
Bronchogen (AEDL)	Lung tissue research	Epigenetic regulation; pulmonary function	Shares EDL C-terminus; lung-specific effects
Epithalon (AEDG)	Anti-aging & pineal research	Telomerase activation; neuroendocrine regulation	Different sequence; distinct research applications

Ovagen is structurally related to Bronchogen, which shares the EDL sequence at its C-terminus. In fact, this illustrates a recurring pattern in the Khavinson peptide family. Overlapping sequences produce tissue-specific effects depending on peptide length and amino acid composition. Consequently, researchers seeking to buy Ovagen in Switzerland often compare it with these related peptides. This comparison helps them select the most appropriate research tool for their specific experimental objectives.

Research Applications

Ovagen research peptide serves a variety of laboratory applications:

• In-vitro studies — Investigation of hepatocyte and GI-epithelial gene-expression regulation in organotypic cultures
• Comparative tissue-specificity screening — Evaluation across the Khavinson bioregulator panel
• Preclinical models — Studies of hepatic stress and regeneration in cell-culture and rodent models
• Chromatin and transcription studies — Reference probe for short-peptide chromatin interaction research
• Epigenetic regulation research — Investigating peptide-DNA interactions and gene expression modulation

Typically, when researchers buy Ovagen in Switzerland, they use it in controlled laboratory settings with appropriate experimental controls. The peptide is soluble in water and buffered aqueous solutions.

Ovagen Product Specifications

Parameter	Specification
Product Name	Ovagen
Alternative Names	EDL, Glu-Asp-Leu, EDL tripeptide, hepatic/GI peptide bioregulator
Amount	20 mg
Form	Lyophilized powder
Amino Acid Sequence	Glu-Asp-Leu (EDL)
Molecular Formula	C₁₅H₂₅N₃O₈
Molecular Weight	375.37 g/mol
CAS Number	9046-70-2
Purity	Not verified / not provided
Appearance	White to off-white lyophilized powder
Solubility	Soluble in water and buffered aqueous solutions
Research Category	Healing & Regeneration / Cellular Research & Signaling
Research Use	Laboratory research use only
Storage	–20°C or below, desiccated, protected from light

How to Evaluate Ovagen Quality

When researchers seek to buy Ovagen in Switzerland for laboratory studies, they should consider several quality indicators:

• Identity verification — Confirmation of the correct amino acid sequence (Glu-Asp-Leu) through analytical methods
• Purity assessment — High-performance liquid chromatography (HPLC) analysis to determine peptide purity
• Batch and lot information — Traceability through batch-specific documentation
• Mass spectrometry — Confirmation of molecular weight (375.37 g/mol)
• Certificate of Analysis (CoA) — Documentation of analytical testing results
• Appearance — White to off-white lyophilized powder
• Storage conditions — Proper desiccated storage at –20°C or below

Therefore, researchers should always request batch-specific analytical documentation when purchasing Ovagen peptide powder for their investigations.

Understanding the Certificate of Analysis

A Certificate of Analysis (CoA) provides analytical testing results for a specific batch of a research peptide. For Ovagen research peptide, a CoA typically includes identity confirmation, purity determination, batch and lot numbers, analytical methods, and molecular weight confirmation.

However, it is important to understand that a CoA confirms the identity and purity of a research compound. Nevertheless, it does not establish safety, efficacy, therapeutic effectiveness, or suitability for human use. Ovagen is intended strictly for laboratory research purposes.

Storage and Stability

Proper storage of Ovagen is essential for maintaining peptide stability:

• Long-term storage — Store at –20°C or below, desiccated, and protected from light
• Handling — Weigh under dry conditions as the peptide is hygroscopic
• Reconstitution — Reconstitute in sterile water or appropriate buffered aqueous solution depending on assay requirements
• Avoid agitation — Avoid vigorous agitation during dissolution
• Filter sterilization — Filter sterilize if required (e.g., 0.22 µm) prior to use
• Aliquoting — Aliquot and store reconstituted solutions at –20°C or below to minimize degradation
• Avoid freeze-thaw — Avoid repeated freeze–thaw cycles

Hence, prolonged exposure to light, elevated temperature, or aqueous environments may reduce peptide stability.

Frequently Asked Questions About Ovagen

What is Ovagen?

Ovagen is a synthetic tripeptide with the amino acid sequence Glu-Asp-Leu (EDL), developed within the Khavinson peptide bioregulator framework. Researchers investigate it for its potential role in hepatic and gastrointestinal tissue research.

What is Ovagen researched for?

Researchers study Ovagen for liver tissue support, GI mucosal health, hepatic function, and digestive tissue repair. Additionally, studies have examined its effects on cellular aging markers including Ki-67, p53, p16, p21, and SIRT-6.

What is the amino acid sequence of Ovagen?

The amino acid sequence of Ovagen is Glu-Asp-Leu (EDL).

What is the molecular weight of Ovagen?

The molecular weight of Ovagen is approximately 375.37 g/mol (molecular formula C₁₅H₂₅N₃O₈).

Is Ovagen synthetic?

Yes, Ovagen is a synthetic linear tripeptide bioregulator.

What research exists for Ovagen?

Research on Ovagen consists primarily of Russian preclinical studies and in-vitro investigations. The peptide bioregulation theory proposes that short peptides can selectively regulate gene expression in specific tissues, though this mechanism remains unvalidated by Western research standards.

What are the main research areas for Ovagen?

Main research areas include hepatic gene expression modulation, gastrointestinal epithelial signaling, cellular aging markers, hepatocyte regeneration, and peptide-DNA interaction studies.

What is the difference between Ovagen and Bronchogen?

Ovagen (EDL) is a tripeptide targeting liver and GI tissue, while Bronchogen (AEDL) is a tetrapeptide targeting lung tissue. They share the EDL sequence at the C-terminus but have different tissue-specific effects.

How should researchers evaluate Ovagen quality?

Researchers should evaluate identity verification, purity assessment, batch information, mass spectrometry confirmation, Certificate of Analysis, appearance, and proper storage conditions.

What does a Certificate of Analysis show?

A CoA shows identity confirmation, purity determination, batch and lot numbers, analytical methods used, and molecular weight confirmation for a specific batch.

Is Ovagen approved as a medicine?

Ovagen is not approved by any regulatory agency including FDA, EMA, or Swissmedic. Furthermore, no human clinical trials have been registered or published for this compound.

Is Ovagen intended for human use?

Ovagen is intended strictly for laboratory research use only. It is not for human or veterinary application.

Where can researchers buy Ovagen in Switzerland?

Researchers can buy Ovagen in Switzerland through Core Peptides, a trusted research peptide supplier offering high-quality research compounds for laboratory studies.

Related Research Peptides

Researchers interested in Ovagen may also wish to explore related peptides within the Khavinson bioregulator family and complementary research areas:

• [PRODUCT LINK: Livagen] — A related liver-targeting peptide bioregulator with a different amino acid sequence
• [PRODUCT LINK: Bronchogen] — A tetrapeptide lung bioregulator sharing the EDL C-terminal sequence
• [PRODUCT LINK: Epithalon] — A peptide investigated for anti-aging and pineal gland research
• [PRODUCT LINK: GHK-Cu] — A copper-binding peptide investigated for tissue regeneration and anti-aging research
• [PRODUCT LINK: BPC-157] — A peptide studied for tissue healing and gastrointestinal research

Explore Healing & Regeneration

Ovagen belongs to the [INTERNAL LINK: Healing & Regeneration] category, which features research peptides investigated for tissue repair, cellular regeneration, and organ-specific function. Researchers may also find relevant compounds in the [INTERNAL LINK: Cellular Research & Signaling] category, which explores peptide-mediated gene expression and intracellular signaling pathways.

Further Research

For researchers seeking additional scientific context on Ovagen and related peptide bioregulators, the following resources may be valuable:

• PubMed — Search for « Ovagen » or « Glu-Asp-Leu peptide » for available research publications
• NCBI — Access to genetic and biochemical databases
• Swissmedic — Swiss regulatory authority for therapeutic products (for regulatory context)

Nevertheless, researchers should note that the evidence base for Ovagen is classified as very low. Most research originates from Russian institutions, and independent Western validation remains limited.

Research Disclaimer

Ovagen is a research peptide supplied for laboratory research purposes only. It is not approved for human or veterinary use and is not intended for the diagnosis, treatment, prevention, or cure of any disease.

The information provided on this page is for educational and scientific reference purposes only. It does not constitute medical advice, therapeutic recommendations, or dosing instructions. Researchers are responsible for ensuring compliance with all applicable laws, regulations, and institutional guidelines governing the use of research peptides in their jurisdiction.

All research should be conducted in appropriate laboratory settings with necessary safety precautions and institutional oversight.