P21 (5MG)

What Is P21?

Originating from ciliary neurotrophic factor (CNTF), P21 (also known as P-21 or P021) is a synthetic research peptide. This hexapeptide features the amino acid sequence Ac-DGGLAG-NH2. Notably, researchers primarily investigate P21 in preclinical research for its potential to support neurogenesis, cognitive function, and neuronal plasticity through mechanisms related to Brain-Derived Neurotrophic Factor (BDNF).

As a fragment of CNTF, researchers study P21 for its ability to modulate neurotrophic signaling pathways. Consequently, scientists interested in cognitive enhancement, neuroprotection, and synaptic plasticity have focused on this peptide as a promising experimental compound. For those looking to buy P21 5mg in Switzerland, Core Peptides offers high-quality research-grade material for laboratory applications.

P21 Research Overview

P21 represents a newer generation of research peptides in the cognitive and nootropic space. However, unlike more established compounds such as Semax, P21 remains an experimental peptide, and its evidence base stems primarily from preclinical and animal research.

Research interest in P21 centers on its potential to promote the growth of new neurons and support cognitive function. Specifically, the peptide originates from work on neurotrophic factors, and researchers investigate its ability to influence BDNF-related pathways. Therefore, while the research is still at an early stage, P21 has generated significant interest as a next-generation nootropic peptide.

When researchers buy P21 5mg in Switzerland for laboratory studies, they gain access to a compound that may help elucidate mechanisms of neuroplasticity and cognitive function at the molecular level.

How Does P21 Work?

The proposed mechanism of P21 involves modulation of neurotrophic signaling pathways, particularly those associated with BDNF and CNTF. As a derivative of CNTF, the peptide likely interacts with neurotrophic receptor systems and influences downstream signaling cascades involved in neuronal survival, differentiation, and synaptic plasticity.

In preclinical research, studies have shown that P21 acts similarly to its parent molecule—the 11-mer peptide—by partially inhibiting LIF (Leukemia Inhibitory Factor) activity through the STAT3 pathway. This mechanism directly applies to understanding how neurotrophic factors regulate neuronal function. Consequently, it may have implications for research into learning, memory, and neurodegenerative conditions.

The peptide’s ability to influence neurotrophic signaling makes it a valuable tool for researchers investigating the molecular basis of cognitive function and neuroplasticity. Indeed, those who buy P21 5mg in Switzerland for research purposes are contributing to the growing body of knowledge in this area.

Why Is P21 Studied?

Researchers primarily study P21 for its potential relevance to cognitive function, neurogenesis, and neuroprotection. Scientists are increasingly interested in understanding how neurotrophic factors and their derivatives can influence brain plasticity, learning, and memory.

Moreover, the peptide’s connection to BDNF—a protein critical for neuronal survival, synaptic plasticity, and cognitive function—has made it a focus of neuroscience research. Preclinical studies have explored P21’s effects on neurogenesis and markers relevant to cognition and neuroprotection.

Additionally, researchers study P21 in the context of age-related cognitive decline and neurodegenerative disease models. As the global population ages, understanding mechanisms that support cognitive health has become increasingly important, and P21 represents one avenue of research inquiry.

Researchers who buy P21 5mg in Switzerland from Core Peptides can incorporate this peptide into their studies on neurotrophic signaling, cognitive function, and neuroprotection.

P21 Research Areas

Research Area	Description
Neurogenesis	Investigating P21’s potential to promote the growth and differentiation of new neurons
Cognitive Function	Examining P21’s effects on learning, memory, and cognitive performance in models
Neuroprotection	Exploring P21’s potential to protect neurons from damage and degeneration
Synaptic Plasticity	Studying P21’s role in synaptic remodeling and neuronal connectivity
Neurotrophic Signaling	Analyzing P21’s interaction with CNTF, BDNF, and related pathways
Neurodegenerative Disease Models	Using preclinical models to explore P21’s potential relevance to conditions such as Alzheimer’s disease

Scientific Research on P21

Researchers have primarily conducted scientific studies on P21 in preclinical settings, deriving evidence from animal models and in vitro experiments. The peptide originates from ciliary neurotrophic factor (CNTF), and scientists have investigated its effects on neurotrophic signaling and cognitive function.

For example, a 2010 study demonstrated that P21 acts similarly to its parent molecule by partially inhibiting LIF activity through the STAT3 pathway. This research suggested that P21 and related compounds derived from CNTF may have potential as pro-cognitive agents for preventing and treating learning and memory disorders.

Furthermore, studies have explored P21’s potential in the context of neurogenesis. Researchers have shown that P21 links to BDNF and neurogenesis, generating interest as a next-generation compound for cognitive research.

Nevertheless, researchers should note that P21 has limited human clinical evidence. Most research has occurred in preclinical models, and therefore, findings should interpret as experimental rather than established. Scientists who buy P21 5mg in Switzerland should remain aware of these evidence limitations.

P21 Compared With Related Peptides

Peptide	Relationship to P21	Key Differences
Semax	Both studied as nootropic peptides	Semax has more human use and a longer track record; P21 is newer and largely preclinical
Selank	Both in cognitive peptide research space	Selank has anxiolytic properties; P21 is more focused on neurogenesis
Cerebrolysin	Both associated with cognitive support	Cerebrolysin is a complex peptide mixture; P21 is a single synthetic peptide
CNTF-Derived Peptides	P21 derives from CNTF	P21 is a specific hexapeptide fragment with defined sequence and properties

Research Applications

Researchers utilize P21 in a variety of laboratory research applications, primarily in the fields of neuroscience and cognitive science. Key research applications include:

• Neurogenesis Studies: Investigating P21’s potential to promote neuronal differentiation and growth
• Learning and Memory Research: Exploring P21’s effects on cognitive function in preclinical models
• Neurotrophic Signaling Research: Studying P21’s interaction with CNTF, BDNF, and related pathways
• Neuroprotection Studies: Examining P21’s potential to protect neurons from damage
• Synaptic Plasticity Research: Investigating P21’s role in synaptic remodeling
• Neurodegenerative Disease Research: Exploring P21’s potential relevance to conditions such as Alzheimer’s disease

Researchers who buy P21 5mg in Switzerland can incorporate this peptide into their experimental protocols across these diverse research areas.

P21 Product Specifications

Specification	Detail
Product Name	P21 (also P-21, P021)
Amount	5mg
Form	Lyophilized powder
Sequence	Ac-DGGLAG-NH2
Molecular Formula	C27H42N6O8
Molecular Weight	Approximately 578.7 g/mol
CAS Number	1246751-68-7
Synonyms	P-21, P021, Ac-DGGL-Adamantanylglycine-NH2
Research Category	Cognitive & Nootropic Peptides
Purity	Not provided
Storage	Refer to product documentation

How to Evaluate P21 Quality

When sourcing P21 for research purposes, researchers should consider several quality indicators. A reliable P21 peptide supplier should provide:

• Identity Confirmation: Analytical verification that the peptide matches the expected sequence and molecular weight
• Purity Analysis: Documentation of purity through methods such as HPLC (High-Performance Liquid Chromatography)
• Batch Information: Clear lot numbers and batch traceability
• Certificate of Analysis (CoA): Documentation of analytical testing results
• Proper Labeling: Accurate product identification and storage instructions

Researchers looking to buy P21 5mg in Switzerland should seek suppliers who provide comprehensive documentation and quality assurance. Core Peptides remains committed to supporting research with properly documented products.

Understanding the Certificate of Analysis

A Certificate of Analysis (CoA) provides analytical data for a specific batch of a research peptide. For P21 peptide research, a CoA typically includes:

• Identity Confirmation: Mass spectrometry or other analytical methods confirming the peptide’s identity
• Purity Assessment: HPLC chromatograms showing the purity of the peptide
• Batch/Lot Information: Unique identifiers for traceability
• Analytical Methods: Description of the testing methods used

Importantly, researchers should understand that a CoA demonstrates the chemical identity and purity of a peptide but does not establish safety, efficacy, therapeutic effectiveness, or suitability for human use. The CoA serves as a quality control document for research purposes only.

Storage and Stability

Proper storage of research peptides is essential for maintaining their integrity and stability. For P21 5mg, researchers should refer to the product documentation provided with their order for specific storage recommendations.

General best practices for peptide storage include keeping lyophilized peptides in a cool, dry environment, protected from light and moisture. For specific temperature requirements and reconstitution protocols, consult the applicable product documentation or contact Core Peptides for the applicable storage specifications.

Research Considerations

Researchers incorporating P21 into their studies should be aware of several important considerations:

• Evidence Limitations: P21 has limited human clinical evidence. Most research has occurred in preclinical models.
• Experimental Status: Researchers consider P21 an experimental compound. Findings should interpret within the context of early-stage research.
• Model Differences: Results from animal models may not translate directly to human outcomes.
• Regulatory Status: P21 is not FDA-approved and is intended for laboratory research use only.
• Quality Considerations: Researchers should verify the quality and identity of their P21 through appropriate analytical methods.

Researchers who buy P21 5mg in Switzerland should ensure their studies include appropriate controls and interpret findings with scientific rigor.

Frequently Asked Questions About P21

What is P21?

P21 (also P-21 or P021) is a synthetic hexapeptide derived from ciliary neurotrophic factor (CNTF), studied in preclinical research for its potential role in neurogenesis and cognitive function.

What is P21 researched for?

Researchers primarily investigate P21 for its potential effects on neurogenesis, cognitive function, synaptic plasticity, and neuroprotection.

What is the amino acid sequence of P21?

The amino acid sequence of P21 is Ac-DGGLAG-NH2.

What is the molecular weight of P21?

The molecular weight of P21 is approximately 578.7 g/mol.

What is the CAS number for P21?

The CAS number for P21 is 1246751-68-7.

Is P21 the same as the p21 protein?

No. P21 (the peptide) is a synthetic compound derived from CNTF, distinct from the p21 protein (cyclin-dependent kinase inhibitor p21^Cip1/Waf1), which is a cell cycle regulatory protein. The naming similarity can cause confusion, but they are different entities with different functions.

Does P21 have human clinical evidence?

P21 has limited human clinical evidence. Most research has occurred in preclinical and animal models.

How does P21 compare to Semax?

Both are nootropic peptides, but P21 is newer and largely preclinical, while Semax has more real-world use and a longer track record. Semax has more total research sources and human studies.

Is P21 FDA-approved?

P21 is not FDA-approved. It is intended for laboratory research use only and is not approved for human consumption or therapeutic use.

Can I buy P21 in Switzerland?

Yes, researchers can buy P21 5mg in Switzerland from Core Peptides for laboratory research purposes.

What is the primary research category for P21?

P21 belongs to the Cognitive & Nootropic Peptides category, with secondary relevance to Anti-Aging & Longevity research.

What related peptides are studied alongside P21?

Related peptides include Semax, Selank, Cerebrolysin, and other CNTF-derived or BDNF-related compounds.

What is the evidence level for P21?

P21 has a very low evidence level with 15 total research sources and 0 human studies.

How should P21 be stored?

Refer to the product documentation for specific storage recommendations. Peptides generally store lyophilized in cool, dry conditions.

Is P21 a nootropic peptide?

Yes, researchers classify P21 as a nootropic peptide due to its research focus on cognitive function and neurogenesis.

Related Research Peptides

Researchers interested in P21 may also find the following related peptides relevant to their work:

• Semax – A nootropic peptide with more established research history
• Selank – A cognitive peptide with anxiolytic properties
• Dihexa – A cognitive enhancement peptide
• Cerebrolysin – A complex peptide mixture for cognitive research

For a comprehensive selection of research peptides in Switzerland, explore the Core Peptides catalog.

Explore Cognitive & Nootropic Peptides

P21 is part of our Cognitive & Nootropic Peptides category, which features a range of research peptides investigated for their potential effects on cognitive function, neuroprotection, and brain health. Browse our selection to find the right peptides for your laboratory research.

Further Research

Researchers interested in learning more about P21 and related peptides should consult the primary scientific literature. Key areas of investigation include neurotrophic signaling, neurogenesis, and cognitive function. The PubMed database is an excellent resource for accessing peer-reviewed research articles on these topics.

Research Disclaimer

Core Peptides supplies P21 as a research peptide for laboratory research purposes only. It is not approved for human consumption, therapeutic use, or medical treatment. All information provided is for educational and scientific reference purposes only and does not constitute medical advice. Researchers are responsible for ensuring compliance with all applicable laws and regulations governing the use of research peptides in their jurisdiction, including Switzerland.