Hexarelin (5MG)

What Is Hexarelin and Why Buy It for Research?

Buy Hexarelin 5mg in Switzerland for research into growth hormone axis signaling, ghrelin receptor pharmacology, and cardioprotective pathways. Specifically, Hexarelin (also known as Examorelin) is a synthetic hexapeptide composed of six amino acids with the sequence His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH₂. It is a member of the growth hormone-releasing peptide (GHRP) family and acts as a potent agonist of the growth hormone secretagogue receptor type 1a (GHS-R1a), also known as the ghrelin receptor.

Hexarelin is structurally similar to GHRP-6 but contains a key modification: a 2-methyl group on the tryptophan residue at position 2 (D-2-methyl-Trp), which enhances its potency and stability. This modification, along with the D-amino acid residues, contributes to Hexarelin’s resistance to proteolytic degradation and its potent biological activity. Hexarelin has a molecular weight of 887.0 g/mol and the molecular formula C₄₇H₅₈N₁₂O₆.

In scientific research, Hexarelin serves as a molecular tool for studying GH secretion pathways, ghrelin receptor signaling, and CD36-mediated cardioprotective mechanisms. Furthermore, Core Peptides supplies Hexarelin as a lyophilized powder in a 5mg format exclusively for laboratory use. Therefore, researchers seeking to source this compound for their work will find it readily available when they buy Hexarelin 5mg in Switzerland.

Hexarelin Research Overview: Buy Hexarelin 5mg in Switzerland for GHS-R1a Studies

Centrally, research into Hexarelin has focused on its function as a potent agonist of the ghrelin receptor (GHS-R1a). Hexarelin mimics the action of the endogenous ligand ghrelin, binding to the GHS-R1a with high affinity. This binding event initiates a conformational change in the receptor, a G-protein-coupled receptor (GPCR), leading to the activation of downstream signaling pathways. Hexarelin acts at both hypothalamic and pituitary sites to powerfully stimulate the release of growth hormone (GH).

The primary signaling pathway involves the coupling of activated GHS-R1a to the Gαq/11 subunit of the heterotrimeric G protein. This activation stimulates phospholipase C (PLC), which hydrolyzes phosphatidylinositol 4,5-bisphosphate (PIP2) into two key second messengers: inositol trisphosphate (IP3) and diacylglycerol (DAG). IP3 triggers the release of stored calcium (Ca²⁺) from the endoplasmic reticulum, and this sharp increase in intracellular calcium is critical for the exocytosis of growth hormone-containing vesicles from somatotroph cells in the anterior pituitary. Additionally, DAG activates protein kinase C (PKC), contributing to downstream cellular responses. This canonical pathway is central to the potent secretagogue effect of Hexarelin on growth hormone.

A distinguishing feature of Hexarelin is its unique binding to the scavenger receptor CD36, which mediates many of its GH-independent cardioprotective effects including anti-atherosclerotic and anti-ischemic activity. Accordingly, researchers who buy Hexarelin 5mg in Switzerland from Core Peptides can support their investigations into GHS-R1a signaling, GH secretion, CD36-mediated pathways, and cardioprotective mechanisms.

How Does Hexarelin Work in Research?

Mechanistically, Hexarelin’s proposed action involves functioning as a ghrelin receptor agonist that activates GHS-R1a to stimulate GH release through multiple signaling pathways, with additional CD36-mediated effects. The peptide operates through several interconnected mechanisms.

GHS-R1a Receptor Activation

Hexarelin binds to and activates the growth hormone secretagogue receptor type 1a (GHS-R1a), a G-protein coupled receptor (GPCR) expressed on pituitary somatotrophs and in hypothalamic neurons. Hexarelin is chemically more stable and functionally more potent when compared with ghrelin[reference:0]. In CHO cells transfected with the GHS-R1a, Hexarelin stimulated calcium levels in a concentration-dependent fashion

Intracellular Signaling Cascade

The primary signaling pathway involves the coupling of activated GHS-R1a to the Gαq/11 subunit of the heterotrimeric G protein. This activation stimulates phospholipase C (PLC), which hydrolyzes phosphatidylinositol 4,5-bisphosphate (PIP2) into inositol trisphosphate (IP3) and diacylglycerol (DAG). IP3 triggers the release of stored calcium (Ca²⁺) from the endoplasmic reticulum, and the resulting sharp increase in intracellular calcium is critical for the exocytosis of growth hormone-containing vesicles. Additionally, DAG activates protein kinase C (PKC), which contributes to downstream cellular responses. Hexarelin’s biological effects are mediated by a complex and interconnected network of signaling pathways, including the PLC/PKC, MAPK/ERK, and PI3K/Akt cascades through both GHS-R1a and CD36

Growth Hormone Release

Hexarelin stimulates potent release of endogenous growth hormone from the pituitary gland. The peptide is a potent pituitary GH stimulator when administered intranasally[reference:3]. Plasma growth hormone concentrations increase dose-dependently after injection of the peptide, peaking at about 30 minutes and then decreasing to baseline values within 240 minutes with a half-life of about 55 minutes in humans

CD36-Mediated Cardioprotective Effects

Beyond pituitary GH release, Hexarelin uniquely binds the scavenger receptor CD36, which mediates many of its GH-independent cardioprotective effects including anti-atherosclerotic and anti-ischemic activity[reference:5]. The interaction of Hexarelin with CD36 promotes the transcriptional activation of nuclear receptor PPARγ and target gene profiling involved in metabolism. In macrophages, Hexarelin and other GHRPs induce a molecular cascade involving nuclear liver X receptor LXRα and expression of apolipoprotein E (apoE) and sterol transporters ABCA1 and ABCG1[reference:6]. Studies have demonstrated that Hexarelin protects rat cardiomyocytes from in vivo ischemia/reperfusion injury through interleukin-1 signaling pathway

Neuroprotection

Hexarelin has also demonstrated neuroprotective effects. Studies have shown that Hexarelin modulation of MAPK and PI3K/Akt pathways in Neuro-2A cells inhibits hydrogen peroxide-induced apoptotic toxicity.

Why Is Hexarelin Studied in Switzerland?

Primarily, researchers study Hexarelin because it represents a well-characterized GHS-R1a agonist with unique CD36-mediated cardioprotective effects, enabling investigation of GH secretion, ghrelin receptor signaling, and cardiovascular protection. In fact, this compound offers a focused tool for studying the molecular mechanisms underlying GH pulsatility, cardiac protection, and neuroendocrine regulation.

Research has demonstrated Hexarelin’s relevance across multiple domains. Hexarelin has been shown to be a potent GH secretagogue subject to partial feedback inhibition[reference:9]. The peptide has demonstrated GH-releasing activity after oral, intranasal, intravenous, and subcutaneous administration[reference:10]. Studies have examined the neuroendocrine mechanism by which Hexarelin mediates its actions[reference:11].

Furthermore, Hexarelin has been studied for its potential therapeutic applications in sarcopenia, cachexia, and cardiac conditions[reference:12]. The peptide’s ability to bind both GHS-R1a and CD36 makes it a unique research tool for studying the intersection of growth hormone signaling and cardiovascular protection. Ultimately, researchers who buy Hexarelin 5mg in Switzerland gain access to a comprehensive research tool for investigating GH axis signaling, ghrelin receptor pharmacology, cardioprotective pathways, and neuroprotection.

Hexarelin Research Areas in Laboratory Studies

Research Area	Focus	Evidence Level
GHS-R1a Receptor Pharmacology	Receptor binding, Gq/11 signaling, calcium mobilization, biased agonism	Mechanistic / In Vitro
GH Secretion	Pituitary GH release, GH pulsatility, GH axis regulation	Mechanistic / In Vivo / Clinical
Cardioprotection	CD36-mediated protection, anti-atherosclerotic, anti-ischemic, ischemia-reperfusion	Preclinical
Neuroprotection	MAPK/PI3K/Akt pathways, oxidative stress protection, neuronal survival	Preclinical
Metabolic Regulation	PPARγ activation, LXRα signaling, cholesterol metabolism, ABCA1/ABCG1	Preclinical
Muscle Wasting	Sarcopenia, cachexia, muscle preservation, catabolic states	Preclinical
Hypothalamic-Pituitary Axis	Hypothalamic GHRH release, somatostatin modulation, feedback inhibition	Preclinical / Clinical

Hexarelin Compared With Related Research Compounds

Compound	Research Focus	Mechanism / Target	Key Difference
Hexarelin	GH release, cardioprotection, neuroprotection	GHS-R1a agonist (Gq/11) + CD36 binding	Most potent GH pulse; unique CD36 cardioprotection
GHRP-6	GH release, appetite stimulation	GHS-R1a agonist (Gq/11 signaling)	Stronger appetite stimulation; no CD36 binding
GHRP-2 (Pralmorelin)	GH release, diagnostic testing	GHS-R1a agonist (Gq/11 signaling)	Stronger GH release; less appetite stimulation; no CD36
Ipamorelin	Selective GH release	GHS-R1a agonist (Gq/11 signaling)	Weaker GH pulse; minimal cortisol/prolactin elevation; no CD36

Comparatively, Hexarelin differs from other GHRPs in its unique CD36-mediated cardioprotective effects and potency. On the one hand, Hexarelin is the most potent GH releaser among GHRPs and uniquely binds CD36 for GH-independent cardioprotective effects[reference:13]. On the other hand, GHRP-6 produces notably more appetite stimulation while maintaining similar GH-releasing potency. In contrast, GHRP-2 produces the strongest GH release among GHRPs and has been approved as a diagnostic agent for GH deficiency in Japan, while Ipamorelin provides more selective GH release with minimal cortisol elevation.

Research Applications for Hexarelin in Switzerland

Scientists have investigated Hexarelin across several research domains:

• GHS-R1a Receptor Pharmacology: Researchers use Hexarelin to study ghrelin receptor binding, Gq/11 signaling, calcium mobilization, and biased agonism.
• GH Secretion Studies: The peptide is employed to investigate pituitary GH release, GH pulsatility, and GH axis regulation.
• Cardioprotection Research: Hexarelin’s CD36-mediated cardiac protection, anti-atherosclerotic, and anti-ischemic activity are studied in cardiovascular research models.
• Neuroprotection Studies: Research has examined Hexarelin’s protective effects against oxidative stress and neuronal apoptosis.
• Metabolic Research: Studies have explored Hexarelin’s effects on PPARγ activation, LXRα signaling, and cholesterol metabolism.
• Muscle Wasting Research: Hexarelin has been investigated for its potential in sarcopenia and cachexia models.

Evidently, researchers who buy Hexarelin 5mg in Switzerland gain a valuable addition to any laboratory toolkit focused on GH axis signaling, ghrelin receptor pharmacology, and cardioprotective research.

Hexarelin Product Specifications

Specification	Details
Product Name	Hexarelin (Examorelin)
Alternative Names	Examorelin, Hexarelin Acetate, EP-23905, MF-6003
Amount	5mg
Form	Lyophilized powder
Purity	Not verified
Amino Acid Sequence	His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH₂
Sequence Abbreviation	H-2-Me-WAWFK-NH₂
Peptide Length	6 amino acids (hexapeptide)
Molecular Formula	C₄₇H₅₈N₁₂O₆
Molecular Weight	887.0 g/mol
CAS Number	140703-51-1
PubChem CID	9936740
Half-Life	~55 minutes (human); ~120 minutes (IV bolus, rat)
Receptor Targets	GHS-R1a (Gq/11), CD36 (scavenger receptor)
Research Category	Growth Hormone Peptides / Muscle & Performance
Research Use	Laboratory research use only
CoA	Available upon request (not verified)
Storage	Lyophilized powder should be stored desiccated at -20°C or below, protected from light
Solubility	Soluble in water and bacteriostatic water

How to Evaluate Hexarelin Quality for Research

When sourcing Hexarelin peptide for laboratory research, researchers should consider several quality indicators:

• Identity Confirmation: Analytical techniques such as mass spectrometry should confirm the compound’s molecular weight (887.0 g/mol) and sequence (His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH₂).
• Purity Assessment: High-performance liquid chromatography (HPLC) should verify purity, with ≥98% considered standard for research-grade material.
• Batch Traceability: Lot numbers and batch information enable researchers to track specific production runs.
• Certificate of Analysis: A CoA should accompany the product, detailing analytical testing results including HPLC purity and identity confirmation.
• Labeling Accuracy: Proper labeling should clearly indicate the product name, amount (5mg), sequence, molecular formula, CAS number, and storage recommendations.
• Storage Conditions: Appropriate storage at -20°C or below in desiccated, dark conditions helps maintain peptide stability.

Understanding the Certificate of Analysis

Typically, a Certificate of Analysis (CoA) accompanies research peptides and provides information about the specific batch’s analytical testing. For example, a CoA may include product identity confirmation, purity percentage as determined by HPLC, batch or lot number for traceability, analytical methods used (e.g., mass spectrometry, HPLC), and a physical description of the product.

Nevertheless, it is important to note that a CoA does not establish safety, efficacy, therapeutic effectiveness, or suitability for human use. Instead, it serves as a quality control document that helps researchers verify the identity and purity of the peptide they are using in their laboratory investigations.

Storage and Stability of Hexarelin

Core Peptides supplies Hexarelin as a lyophilized (freeze-dried) powder. To maintain stability and integrity:

• Store the lyophilized powder desiccated at -20°C or below for long-term storage
• Store at 4°C for short-term storage if frequent access is required
• Avoid repeated freeze-thaw cycles
• Reconstitute only immediately before use with appropriate sterile solvents (e.g., bacteriostatic water or sterile water)
• Inject solvent slowly against the inner wall of the vial rather than directly onto the powder; do not shake
• Gently roll the vial in a circular motion to dissolve
• Once reconstituted, store at 4°C for 2-7 days or below -18°C for long-term storage
• For long-term storage, adding a carrier protein (0.1% HSA or BSA) is recommended
• Protect from light and moisture

Frequently Asked Questions About Buying Hexarelin 5mg in Switzerland

What is Hexarelin?

Specifically, Hexarelin (Examorelin) is a synthetic hexapeptide growth hormone secretagogue with the sequence His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH₂. It acts as a potent agonist of the ghrelin receptor (GHS-R1a) and uniquely binds the scavenger receptor CD36.

What is Hexarelin researched for?

Primarily, researchers study Hexarelin for its role as a GHS-R1a agonist in GH secretion, CD36-mediated cardioprotection, and neuroprotection. Studies have investigated its effects on GH release, anti-atherosclerotic activity, anti-ischemic effects, and metabolic regulation.

How does Hexarelin work?

Mechanistically, Hexarelin binds to and activates GHS-R1a, a GPCR on pituitary somatotrophs and hypothalamic neurons, triggering Gαq/11 signaling, PLC activation, calcium mobilization, and GH exocytosis. Additionally, Hexarelin uniquely binds CD36, mediating GH-independent cardioprotective effects.

What is the amino acid sequence of Hexarelin?

The amino acid sequence is His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH₂.

What is the molecular weight of Hexarelin?

The molecular weight is 887.0 g/mol.

What is the molecular formula of Hexarelin?

The molecular formula is C₄₇H₅₈N₁₂O₆.

What is the CAS number of Hexarelin?

The CAS number is 140703-51-1.

Is Hexarelin synthetic?

Yes, Hexarelin is a synthetic peptide produced through solid-phase peptide synthesis.

What is the half-life of Hexarelin?

Hexarelin has a half-life of approximately 55 minutes in humans (IV) and up to 120 minutes in rats (IV bolus)[reference:14][reference:15].

How does Hexarelin differ from other GHRPs?

Hexarelin is the most potent GH releaser among GHRPs and uniquely binds CD36 for GH-independent cardioprotective effects. GHRP-6 produces more appetite stimulation, while GHRP-2 is approved as a diagnostic agent for GH deficiency, and Ipamorelin provides more selective GH release with minimal cortisol elevation.

Where can I buy Hexarelin 5mg in Switzerland?

You can buy Hexarelin 5mg in Switzerland from Core Peptides, a trusted research peptide supplier serving the Swiss scientific community.

How should researchers evaluate Hexarelin quality?

Researchers should look for identity confirmation via mass spectrometry, purity data from HPLC, batch traceability, and a Certificate of Analysis.

Related Research Compounds

Researchers interested in Hexarelin may also find the following related compounds relevant to their work:

• GHRP-6 — A GHRP researched for GH release, appetite stimulation, and ghrelin receptor pharmacology.
• GHRP-2 — A GHRP researched for potent GH release and diagnostic applications.
• Ipamorelin — A GHRP researched for selective GH release with minimal cortisol or prolactin elevation.
• CJC-1295 (Mod GRF 1-29) — A GHRH analog researched for GH synthesis and pulsatile secretion.

Explore Growth Hormone Peptides

Hexarelin belongs to the Growth Hormone Peptides category of research compounds. Growth Hormone Peptides products are studied for their potential roles in GH axis signaling, metabolic regulation, and growth-related pathways. Generally, researchers who buy Hexarelin 5mg in Switzerland often pair it with related compounds in this category to explore complementary pathways in GH research and metabolic studies.

Explore Growth Hormone Blends

Researchers studying multi-peptide GH axis signaling and synergistic GH release may also find relevant compounds in the Growth Hormone Blends subcategory. Hexarelin’s potent GHS-R1a agonism and unique CD36 binding make it a valuable component for investigating receptor pharmacology and convergent GH signaling.

Explore Muscle & Performance

Researchers studying muscle preservation, recovery, and performance-related mechanisms may also find relevant compounds in the Muscle & Performance category. Hexarelin’s effects on GH-dependent anabolic signaling make it a valuable tool for investigating muscle function and recovery.

Further Research

For researchers seeking to deepen their understanding of Hexarelin and its research applications, the following areas may warrant further investigation:

• The relationship between Hexarelin-mediated GHS-R1a activation and specific downstream signaling pathways in different cell types
• Comparative studies between Hexarelin and other GHRPs in various GH axis, cardioprotective, and metabolic models
• The potential for Hexarelin’s CD36-mediated effects to provide insights into cardiovascular protection and atherosclerosis research
• Mechanistic studies on Hexarelin’s interaction with the ghrelin receptor and CD36, and their functional consequences
• Exploration of Hexarelin’s effects on different tissue systems beyond the GH axis and cardiovascular system

Research Disclaimer

Researchers must not use it for human consumption, injection, or any form of therapeutic application. Moreover, this product is not a medicine, pharmaceutical, or medical device. Furthermore, Swissmedic, the FDA, EMA, or any other regulatory authority have not approved it for human use. Researchers should consult Swissmedic for applicable regulations and guidance on research peptide handling in Switzerland.

Generally, the information provided on this page is for educational and scientific reference purposes only. Therefore, it does not constitute medical advice, treatment recommendations, or dosing instructions. Ultimately, researchers bear the responsibility for ensuring that their use of this product complies with all applicable laws, regulations, and institutional guidelines.