Bronchogen (20MG)

What Is Bronchogen and Why Buy It for Research?

Buy Bronchogen 20mg in Switzerland for research into tissue-specific gene regulation, bronchial epithelium biology, and pulmonary repair mechanisms. Specifically, Bronchogen (also known as AEDL, T-33, or Ala-Glu-Asp-Leu) is a synthetic tetrapeptide composed of four amino acids with the sequence Ala-Glu-Asp-Leu (AEDL). It belongs to the family of Khavinson peptide bioregulators—short synthetic peptides (2-4 amino acids) proposed to regulate gene expression in their target organs through direct interaction with DNA and histone proteins.

In scientific research, Bronchogen serves as a molecular tool for studying tissue-specific gene expression regulation in bronchial epithelium experimental systems. Researchers consider this peptide particularly valuable for investigating pulmonary cell models, DNA stabilization, and epithelial differentiation pathways. Furthermore, Core Peptides supplies Bronchogen as a lyophilized powder in a 20mg format exclusively for laboratory use. Therefore, researchers seeking to source this compound for their work will find it readily available when they buy Bronchogen 20mg in Switzerland.

Bronchogen Research Overview: Buy Bronchogen 20mg in Switzerland for Pulmonary Gene Expression Studies

Centrally, research into Bronchogen has focused on its function as a tissue-specific bioregulator targeting the bronchial epithelium. Endogenously, bronchial epithelial cells play a critical role in maintaining respiratory health through mucin production, surfactant protein synthesis, and epithelial differentiation pathways. Bronchogen was designed based on amino acid analysis of polypeptide extracts from bronchial mucosa tissue, with the aim of restoring and maintaining normal function of these cells.

Unlike conventional pharmaceutical agents that act through receptor-mediated signaling, Khavinson’s bioregulator theory proposes that AEDL penetrates cell nuclei and interacts directly with DNA at specific sequence motifs, thereby modulating transcription of tissue-relevant genes. Biophysical studies using spectrophotometry, viscometry, and circular dichroism have demonstrated that the AEDL peptide interacts with DNA in the major groove at the guanine N7 site without visible distortion of the double helix structure. The peptide binds specifically to a CTCC DNA sequence motif. Accordingly, researchers who buy Bronchogen 20mg in Switzerland from Core Peptides can support their investigations into peptide-DNA interactions, gene expression regulation, and pulmonary biology.

How Does Bronchogen Work in Research?

Mechanistically, Bronchogen’s proposed action involves functioning as a DNA-stabilizing agent that modulates gene expression in bronchial epithelial cells. Thermodynamic studies using differential scanning microcalorimetry have demonstrated that Bronchogen increases the melting temperature of DNA from calf thymus and mouse liver by 3.1°C, indicating its role as a DNA-stabilizing agent. The binding occurs with both strands of DNA, primarily with nitrogen bases, and is considered strong and occasional in nature.

In cultured human bronchial epithelial cells, Bronchogen has been reported to modulate transcription of mucin and surfactant-associated genes (MUC4, MUC5AC, SFTPA1) and to alter levels of proliferation- and apoptosis-associated proteins. Additionally, research indicates that Bronchogen regulates the expression of genes including MK167, MCL1, TP53, CD79A, and NOS-3, and modulates levels of Mcl-1, p53, CD79, and NOS-3 markers. Specifically, Bronchogen inhibits expression of the proapoptotic protein p53 in cells of human bronchial epithelium.

Furthermore, Bronchogen has been shown to cause deheterochromatinization of general, facultative, and ribosomal heterochromatin, effectively releasing locked genes. Within the Khavinson short-peptide model, peptides of this class are studied as candidate cell-penetrating regulators that may interact with DNA and chromatin to influence promoter activity. Bronchogen is therefore used to examine putative peptide-DNA interactions and downstream transcriptional readouts in vitro.

Why Is Bronchogen Studied in Switzerland?

Primarily, researchers study Bronchogen because it represents a well-characterized tetrapeptide bioregulator that enables investigation of tissue-specific gene expression, DNA stabilization, and pulmonary epithelial biology. In fact, this compound offers a focused tool for studying the molecular mechanisms underlying bronchial epithelium function, inflammation resolution, and tissue repair.

Preclinical studies have demonstrated Bronchogen’s efficacy across multiple research domains. In a rat model of chronic obstructive pulmonary disease (COPD) created by intermittent exposure to nitrogen dioxide, Bronchogen treatment decreased neutrophilic inflammation, normalized cellular composition and pro-inflammatory cytokine profiles in the bronchoalveolar space, and restored the structure and functional activity of bronchial epithelium. Administration of the tetrapeptide for one month eliminated symptoms of bronchial epithelium remodeling typical of COPD, including goblet cell hyperplasia, squamous metaplasia, lymphocytic infiltration, and emphysema, while restoring ciliated cells. These effects were accompanied by an increase in secretory immunoglobulin A (a local immunity marker) and surfactant protein B, responsible for reducing alveolar surface tension. Ultimately, researchers who buy Bronchogen 20mg in Switzerland gain access to a research tool that may help uncover mechanisms underlying pulmonary inflammation, epithelial repair, and tissue-specific gene regulation.

Bronchogen Research Areas in Laboratory Studies

Research Area	Focus	Evidence Level
Gene Expression Regulation	MUC4, MUC5AC, SFTPA1, MK167, MCL1, TP53, CD79A, NOS-3 modulation	Mechanistic / In Vitro
DNA Interaction and Stabilization	DNA melting temperature, CTCC sequence binding, chromatin deheterochromatinization	Mechanistic
Pulmonary Inflammation	COPD models, neutrophilic inflammation, cytokine profiles	Animal / Preclinical
Bronchial Epithelium Repair	Epithelial remodeling, goblet cell hyperplasia, squamous metaplasia, ciliated cell restoration	Animal / Preclinical
Surfactant and Mucin Biology	Surfactant protein B, secretory immunoglobulin A, mucin production	Animal / Preclinical
Apoptosis and Proliferation	p53 inhibition, Ki-67 modulation, Mcl-1 regulation	Mechanistic / In Vitro
Anti-Aging Research	Age-related lung function decline, DNA reactivation, cellular senescence	Emerging Research

Bronchogen Compared With Related Research Compounds

Compound	Research Focus	Mechanism / Target	Key Difference
Bronchogen (AEDL)	Bronchial epithelium, pulmonary gene regulation	DNA stabilization, CTCC sequence binding, gene expression modulation	Tetrapeptide; lung tissue-specific bioregulator
Epitalon	Pineal gland, aging, circadian rhythms	DNA interaction, telomerase activation	Different target tissue; Ala-Glu-Asp-Gly sequence
Vilon	Immune system, thymus	DNA interaction, immune modulation	Different target tissue; Lys-Glu sequence
Cortagen	Nervous system, brain	DNA interaction, neuroprotection	Different target tissue; Ala-Glu-Asp-Pro sequence

Comparatively, Bronchogen differs from other Khavinson peptide bioregulators in its tissue specificity and amino acid sequence. On the one hand, Epitalon (Ala-Glu-Asp-Gly) targets pineal gland function and aging-related processes, while Vilon (Lys-Glu) focuses on immune system modulation. On the other hand, Bronchogen (Ala-Glu-Asp-Leu) is specifically designed for bronchial and pulmonary tissue research, with demonstrated effects on mucin genes, surfactant proteins, and epithelial repair pathways. In contrast, Cortagen (Ala-Glu-Asp-Pro) targets nervous system tissues.

Research Applications for Bronchogen in Switzerland

Scientists have investigated Bronchogen across several research domains:

• Gene Expression Studies: Researchers use Bronchogen to investigate tissue-specific gene regulation in bronchial epithelial cell cultures, including modulation of MUC4, MUC5AC, SFTPA1, and proliferation/apoptosis markers.
• DNA Interaction Research: The peptide serves as a probe compound for studying short peptide-DNA promoter interactions, DNA stabilization, and chromatin remodeling.
• Pulmonary Inflammation Models: Preclinical studies have examined Bronchogen’s effects in rodent models of experimental lung inflammation, fibrosis, and toxic lung injury.
• Epithelial Repair and Regeneration: Investigations have explored Bronchogen’s role in restoring bronchial epithelium structure and function in COPD models.
• Cellular Models of Senescence: Bronchogen is used to study epithelial proliferation, apoptosis, and replicative senescence in bronchial epithelial cells.
• Surfactant and Mucin Biology: The peptide is employed to investigate surfactant protein production and mucin gene regulation in pulmonary research models.

Evidently, researchers who buy Bronchogen 20mg in Switzerland gain a valuable addition to any laboratory toolkit focused on pulmonary biology, gene regulation, and tissue-specific peptide research.

Bronchogen Product Specifications

Specification	Details
Product Name	Bronchogen (AEDL)
Alternative Names	AEDL, T-33, Ala-Glu-Asp-Leu, Bronchogen peptide bioregulator
Amount	20mg
Form	Lyophilized powder (white to off-white)
Purity	Not verified (≥98.5% to ≥99% reported by some suppliers)
Amino Acid Sequence	H-Ala-Glu-Asp-Leu-OH (AEDL)
Sequence (3-letter)	Ala-Glu-Asp-Leu
Peptide Length	4 amino acids (tetrapeptide)
Molecular Formula	C₁₈H₃₀N₄O₉
Molecular Weight	446.45 g/mol
CAS Number	Not available
Research Category	Immunity & Inflammation / Healing & Regeneration
Research Use	Laboratory research use only
CoA	Available upon request (not verified)
Storage	Lyophilized powder should be stored desiccated at -20°C or below, protected from light
Solubility	Soluble in water and buffered aqueous solutions

How to Evaluate Bronchogen Quality for Research

When sourcing Bronchogen peptide for laboratory research, researchers should consider several quality indicators:

• Identity Confirmation: Analytical techniques such as mass spectrometry should confirm the compound’s molecular weight (446.45 g/mol) and sequence (H-Ala-Glu-Asp-Leu-OH).
• Purity Assessment: High-performance liquid chromatography (HPLC) should verify purity, with ≥98% considered standard for research-grade material.
• Batch Traceability: Lot numbers and batch information enable researchers to track specific production runs.
• Certificate of Analysis: A CoA should accompany the product, detailing analytical testing results including HPLC purity and identity confirmation.
• Labeling Accuracy: Proper labeling should clearly indicate the product name, amount (20mg), sequence, molecular formula, and storage recommendations.
• Storage Conditions: Appropriate storage at -20°C or below in desiccated, dark conditions helps maintain peptide stability.

Understanding the Certificate of Analysis

Typically, a Certificate of Analysis (CoA) accompanies research peptides and provides information about the specific batch’s analytical testing. For example, a CoA may include product identity confirmation, purity percentage as determined by HPLC, batch or lot number for traceability, analytical methods used (e.g., mass spectrometry, HPLC), and a physical description of the product.

Nevertheless, it is important to note that a CoA does not establish safety, efficacy, therapeutic effectiveness, or suitability for human use. Instead, it serves as a quality control document that helps researchers verify the identity and purity of the peptide they are using in their laboratory investigations.

Storage and Stability of Bronchogen

Core Peptides supplies Bronchogen as a lyophilized (freeze-dried) powder. To maintain stability and integrity:

• Store the lyophilized powder desiccated at -20°C or below for long-term storage
• Store at 4°C for short-term storage if frequent access is required
• Avoid repeated freeze-thaw cycles
• Weigh under dry conditions; the peptide is hygroscopic
• Reconstitute only immediately before use with appropriate sterile solvents (sterile water or buffered aqueous solutions)
• Inject solvent slowly against the inner wall of the vial; avoid vigorous agitation during dissolution
• Filter sterilize if required (e.g., 0.22 µm) immediately prior to use
• Aliquot and store reconstituted solutions at -20°C or below to minimize degradation
• Protect from light and moisture

Frequently Asked Questions About Buying Bronchogen 20mg in Switzerland

What is Bronchogen?

Specifically, Bronchogen (AEDL, T-33) is a synthetic tetrapeptide with the amino acid sequence Ala-Glu-Asp-Leu (AEDL). It is a tissue-specific bioregulator developed by Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology.

What is Bronchogen researched for?

Primarily, researchers study Bronchogen for its role in bronchial epithelium gene expression regulation, DNA stabilization, and pulmonary tissue repair. Studies have investigated its effects on mucin and surfactant-associated genes, inflammation modulation, and epithelial repair in COPD models.

How does Bronchogen work?

Mechanistically, Bronchogen functions as a DNA-stabilizing agent that penetrates cell nuclei and interacts directly with DNA at specific sequence motifs (CTCC), thereby modulating transcription of tissue-relevant genes in bronchial epithelial cells. It also causes deheterochromatinization, releasing locked genes.

What is the amino acid sequence of Bronchogen?

The amino acid sequence is H-Ala-Glu-Asp-Leu-OH (AEDL).

What is the molecular weight of Bronchogen?

The molecular weight is 446.45 g/mol.

What is the molecular formula of Bronchogen?

The molecular formula is C₁₈H₃₀N₄O₉.

Is Bronchogen synthetic?

Yes, Bronchogen is a synthetic peptide produced through solid-phase peptide synthesis.

What research exists on Bronchogen?

Research on Bronchogen includes biophysical studies demonstrating DNA stabilization, in vitro studies showing modulation of mucin and surfactant genes in human bronchial epithelial cells, and preclinical studies in rat COPD models showing reduced inflammation and restored epithelial structure.

Is Bronchogen approved as a medicine?

No. Regulatory authorities have not approved Bronchogen as a medicine, pharmaceutical, or therapeutic agent. It is a research tool for laboratory use only.

Is Bronchogen intended for human use?

No. Bronchogen is intended for laboratory research use only and is not for human consumption, injection, or therapeutic application.

Where can I buy Bronchogen 20mg in Switzerland?

You can buy Bronchogen 20mg in Switzerland from Core Peptides, a trusted research peptide supplier serving the Swiss scientific community.

How should researchers evaluate Bronchogen quality?

Researchers should look for identity confirmation via mass spectrometry, purity data from HPLC, batch traceability, and a Certificate of Analysis.

Related Research Compounds

Researchers interested in Bronchogen may also find the following related compounds relevant to their work:

• Epitalon — A related Khavinson tetrapeptide (Ala-Glu-Asp-Gly) researched for pineal gland function, aging, and telomerase activation.
• Vilon — A related Khavinson dipeptide (Lys-Glu) researched for immune system modulation and thymus function.
• Cortagen — A related Khavinson tetrapeptide (Ala-Glu-Asp-Pro) researched for nervous system tissue and neuroprotection.
• BPC-157 — A peptide researched for tissue healing, gastrointestinal protection, and angiogenesis.

Explore Immunity & Inflammation

Bronchogen belongs to the Immunity & Inflammation category of research compounds. Immunity & Inflammation products are studied for their potential roles in inflammatory signaling, immune modulation, and tissue protection. Generally, researchers who buy Bronchogen 20mg in Switzerland often pair it with related compounds in this category to explore complementary pathways in pulmonary inflammation and epithelial repair research.

Explore Healing & Regeneration

Researchers studying tissue repair, epithelial regeneration, and cytoprotective mechanisms may also find relevant compounds in the Healing & Regeneration category. Bronchogen’s effects on epithelial repair and tissue regeneration make it a valuable tool for investigating pulmonary recovery and regenerative biology.

Further Research

For researchers seeking to deepen their understanding of Bronchogen and its research applications, the following areas may warrant further investigation:

• The relationship between Bronchogen-mediated DNA stabilization and specific downstream gene expression changes in bronchial epithelial cells
• Comparative studies between Bronchogen and other Khavinson peptides in various pulmonary and tissue-specific models
• The potential role of Bronchogen in modulating age-related lung function decline and cellular senescence
• Mechanistic studies on Bronchogen’s interaction with DNA at the CTCC sequence motif and its functional consequences
• Exploration of Bronchogen’s effects on different cell types and tissue systems beyond bronchial epithelium

Research Disclaimer

Bronchogen is a research peptide supplied for laboratory research use only. Researchers must not use it for human consumption, injection, or any form of therapeutic application. Moreover, this product is not a medicine, pharmaceutical, or medical device. Furthermore, Swissmedic, the FDA, EMA, or any other regulatory authority have not approved it for human use. Researchers should consult Swissmedic for applicable regulations and guidance on research peptide handling in Switzerland.

Generally, the information provided on this page is for educational and scientific reference purposes only. Therefore, it does not constitute medical advice, treatment recommendations, or dosing instructions. Ultimately, researchers bear the responsibility for ensuring that their use of this product complies with all applicable laws, regulations, and institutional guidelines.

Finally, all research involving peptides should be conducted by qualified personnel in appropriate laboratory settings with proper safety protocols.