Ipamorelin (5MG)

What Is Ipamorelin and Why Buy It for Research?

Buy Ipamorelin 5mg in Switzerland for research into growth hormone axis signaling, ghrelin receptor pharmacology, and selective GH release pathways. Specifically, Ipamorelin is a synthetic pentapeptide composed of five amino acids with the sequence Aib-His-D-2-Nal-D-Phe-Lys-NH₂. It is a member of the growth hormone-releasing peptide (GHRP) family and acts as a potent and selective agonist of the growth hormone secretagogue receptor type 1a (GHS-R1a), also known as the ghrelin receptor.

Ipamorelin is structurally distinct from other GHRPs due to the presence of aminoisobutyric acid (Aib) at the N-terminus. This modification enhances its stability and contributes to its unique selectivity profile. The peptide has a molecular weight of 711.85 g/mol and the molecular formula C₃₈H₄₉N₉O₅. In scientific research, Ipamorelin serves as a molecular tool for studying GH secretion pathways, ghrelin receptor signaling, and selective receptor activation. Furthermore, Core Peptides supplies Ipamorelin as a lyophilized powder in a 5mg format exclusively for laboratory use. Therefore, researchers seeking to source this compound for their work will find it readily available when they buy Ipamorelin 5mg in Switzerland.

Ipamorelin Research Overview: Buy Ipamorelin 5mg in Switzerland for GHS-R1a Studies

Centrally, research into Ipamorelin has focused on its function as a potent and selective agonist of the ghrelin receptor (GHS-R1a). Ipamorelin mimics the action of the endogenous ligand ghrelin, binding to the GHS-R1a with high affinity. This binding event initiates a conformational change in the receptor, a G-protein-coupled receptor (GPCR), leading to the activation of downstream signaling pathways. Ipamorelin acts at both hypothalamic and pituitary sites to stimulate the release of growth hormone (GH).

The primary signaling pathway involves the coupling of activated GHS-R1a to the Gαq/11 subunit of the heterotrimeric G protein. This activation stimulates phospholipase C (PLC), which hydrolyzes phosphatidylinositol 4,5-bisphosphate (PIP2) into two key second messengers: inositol trisphosphate (IP3) and diacylglycerol (DAG). IP3 triggers the release of stored calcium (Ca²⁺) from the endoplasmic reticulum, and this sharp increase in intracellular calcium is critical for the exocytosis of growth hormone-containing vesicles from somatotroph cells in the anterior pituitary. Additionally, DAG activates protein kinase C (PKC), contributing to downstream cellular responses.

A distinguishing feature of Ipamorelin is its favorable selectivity profile. Consequently, Ipamorelin offers a more targeted approach for studying isolated GH effects. Accordingly, researchers who buy Ipamorelin 5mg in Switzerland from Core Peptides can support their investigations into GHS-R1a signaling, selective GH secretion, and receptor pharmacology.

How Does Ipamorelin Work in Research?

Mechanistically, Ipamorelin’s proposed action involves functioning as a ghrelin receptor agonist that activates GHS-R1a to stimulate GH release through multiple signaling pathways. The peptide operates through several interconnected mechanisms.

GHS-R1a Receptor Activation

Ipamorelin binds to and activates the growth hormone secretagogue receptor type 1a (GHS-R1a), a G-protein coupled receptor (GPCR) expressed on pituitary somatotrophs and in hypothalamic neurons. This binding event initiates a conformational change in the receptor, leading to the activation of downstream signaling pathways. Ipamorelin demonstrates potent agonism at GHS-R1a with an EC50 of approximately 3-5 nM for calcium mobilization. The peptide’s unique aminoisobutyric acid (Aib) residue at the N-terminus contributes to its enhanced metabolic stability and favorable selectivity profile.

Intracellular Signaling Cascade

The primary signaling pathway involves the coupling of activated GHS-R1a to the Gαq/11 subunit of the heterotrimeric G protein. This activation stimulates phospholipase C (PLC), which hydrolyzes phosphatidylinositol 4,5-bisphosphate (PIP2) into two key second messengers: inositol trisphosphate (IP3) and diacylglycerol (DAG). IP3 triggers the release of stored calcium (Ca²⁺) from the endoplasmic reticulum, and the resulting sharp increase in intracellular calcium is critical for the exocytosis of growth hormone-containing vesicles. Additionally, DAG activates protein kinase C (PKC), which contributes to downstream cellular responses.

Growth Hormone Release

Ipamorelin stimulates the release of endogenous growth hormone from the pituitary gland. The peptide has been shown to be effective at stimulating GH production in research subjects. Its effect is synergistic with GHRH analogs such as CJC-1295 (Mod GRF 1-29), producing amplified GH pulses. The half-life of Ipamorelin is approximately 2 hours, making it a valuable tool for pulsatile GH studies.

Selective GH Release Profile

Unlike other GHRPs, Ipamorelin produces highly selective GH release with negligible cortisol or prolactin elevation. This selectivity is a key distinguishing feature that makes Ipamorelin valuable for studies requiring isolated GH effects without adrenal axis activation. The peptide achieves this selectivity through biased agonism at the GHS-R1a receptor, preferentially activating the Gq/11 pathway while minimally engaging other signaling pathways.

Why Is Ipamorelin Studied in Switzerland?

Primarily, researchers study Ipamorelin because it represents a selective GHS-R1a agonist that enables investigation of GH secretion, ghrelin receptor pharmacology, and metabolic regulation without the confounding effects of cortisol or prolactin elevation. In fact, this compound offers a focused tool for studying the molecular mechanisms underlying GH pulsatility, metabolic regulation, and selective receptor activation.

Research has demonstrated Ipamorelin’s relevance across multiple domains. Ipamorelin has been shown to be a potent GH secretagogue with favorable selectivity, producing significant GH release with minimal elevation of cortisol and prolactin. The peptide has been studied for its effects on muscle growth, bone density, and metabolic regulation in preclinical models.

Furthermore, Ipamorelin is frequently used in combination with GHRH analogs such as CJC-1295 (Mod GRF 1-29) for synergistic GH release studies. The no-DAC variant of CJC-1295 is the typical pairing partner because its 30-minute half-life matches Ipamorelin’s roughly 2-hour half-life, preserving a pulsatile pattern. Studies have shown significantly improved muscle function in murine models with glucocorticoid-induced muscle loss when combining Ipamorelin with CJC-1295. Ultimately, researchers who buy Ipamorelin 5mg in Switzerland gain access to a comprehensive research tool for investigating GH axis signaling, ghrelin receptor pharmacology, and metabolic regulation.

Ipamorelin Research Areas in Laboratory Studies

Research Area	Focus	Evidence Level
GHS-R1a Receptor Pharmacology	Receptor binding, biased agonism, Gq/11 signaling, calcium mobilization	Mechanistic / In Vitro
Selective GH Secretion	Pituitary GH release, GH pulsatility, minimal cortisol/prolactin effects	Mechanistic / In Vivo
Metabolic Regulation	Lipolysis, protein synthesis, energy homeostasis, metabolic adaptation	Preclinical
Muscle Research	Muscle preservation, recovery, anabolic signaling, lean body mass	Preclinical
Synergistic GH Release	Combination with GHRH analogs, CJC-1295 pairing, pulsatile secretion	Preclinical
Bone Research	Bone density, osteoblast function, skeletal health	Preclinical
Neuroprotection	Neuroendocrine signaling, CNS effects, neuroprotection research	Emerging Research

Ipamorelin Compared With Related Research Compounds

Compound	Research Focus	Mechanism / Target	Key Difference
Ipamorelin	Selective GH release, metabolic regulation	GHS-R1a agonist (Gq/11 biased)	Minimal cortisol/prolactin elevation; selective GH release
GHRP-2	Potent GH release, diagnostic testing	GHS-R1a agonist (Gq/11 signaling)	Stronger GH release; moderate cortisol/prolactin elevation
GHRP-6	GH release, appetite stimulation	GHS-R1a agonist (Gq/11 signaling)	Stronger appetite stimulation; moderate cortisol/prolactin elevation
Hexarelin	GH release, cardioprotection	GHS-R1a agonist + CD36 binding	Most potent GH pulse; CD36 cardioprotection; cortisol/prolactin elevation

Comparatively, Ipamorelin differs from other GHRPs in its selectivity and research applications. On the one hand, Ipamorelin produces highly selective GH release with negligible cortisol or prolactin elevation, making it the preferred choice for studies requiring isolated GH effects. On the other hand, GHRP-2 produces the strongest GH release among GHRPs and has been approved as a diagnostic agent for GH deficiency in Japan. In contrast, GHRP-6 produces notably more appetite stimulation, while Hexarelin uniquely binds CD36 for cardioprotective effects.

Research Applications for Ipamorelin in Switzerland

Scientists have investigated Ipamorelin across several research domains:

• GHS-R1a Receptor Pharmacology: Researchers use Ipamorelin to study ghrelin receptor binding, biased agonism, Gq/11 signaling, and calcium mobilization.
• Selective GH Secretion Studies: The peptide is employed to investigate pituitary GH release, GH pulsatility, and the effects of selective GH elevation with minimal cortisol/prolactin interference.
• Metabolic Regulation Studies: Ipamorelin is used to study lipolysis, protein synthesis, energy homeostasis, and metabolic adaptation.
• Muscle Research: The peptide has been investigated for its potential to preserve muscle mass and promote recovery in preclinical models.
• Synergistic GH Release Studies: Ipamorelin is frequently combined with GHRH analogs such as CJC-1295 to study synergistic GH release and pulsatile secretion dynamics.
• Bone Research: Studies have examined Ipamorelin’s effects on bone density and skeletal health.

Evidently, researchers who buy Ipamorelin 5mg in Switzerland gain a valuable addition to any laboratory toolkit focused on GH axis signaling, ghrelin receptor pharmacology, and metabolic research.

Ipamorelin Product Specifications

Specification	Details
Product Name	Ipamorelin
Alternative Names	Ipamorelin acetate, NNC 26-0161
Amount	5mg
Form	Lyophilized powder
Purity	Not verified (≥98-99% HPLC purity reported by some suppliers)
Amino Acid Sequence	Aib-His-D-2-Nal-D-Phe-Lys-NH₂
Sequence Abbreviation	Aib-H-2-Nal-WFK-NH₂
Peptide Length	5 amino acids (pentapeptide)
Molecular Formula	C₃₈H₄₉N₉O₅
Molecular Weight	711.85 g/mol
CAS Number	170851-70-4
PubChem CID	9831218
Half-Life	Approximately 2 hours
Research Category	Growth Hormone Peptides / Muscle & Performance
Research Use	Laboratory research use only
CoA	Available upon request (not verified)
Storage	Lyophilized powder should be stored desiccated at -20°C or below, protected from light
Solubility	Soluble in water and bacteriostatic water; reconstitute slowly

How to Evaluate Ipamorelin Quality for Research

When sourcing Ipamorelin peptide for laboratory research, researchers should consider several quality indicators:

• Identity Confirmation: Analytical techniques such as mass spectrometry should confirm the compound’s molecular weight (711.85 g/mol) and sequence (Aib-His-D-2-Nal-D-Phe-Lys-NH₂).
• Purity Assessment: High-performance liquid chromatography (HPLC) should verify purity, with ≥98% considered standard for research-grade material.
• Batch Traceability: Lot numbers and batch information enable researchers to track specific production runs.
• Certificate of Analysis: A CoA should accompany the product, detailing analytical testing results including HPLC purity and identity confirmation.
• Labeling Accuracy: Proper labeling should clearly indicate the product name, amount (5mg), sequence, molecular formula, CAS number, and storage recommendations.
• Storage Conditions: Appropriate storage at -20°C or below in desiccated, dark conditions helps maintain peptide stability.

Understanding the Certificate of Analysis

Typically, a Certificate of Analysis (CoA) accompanies research peptides and provides information about the specific batch’s analytical testing. For example, a CoA may include product identity confirmation, purity percentage as determined by HPLC, batch or lot number for traceability, analytical methods used (e.g., mass spectrometry, HPLC), and a physical description of the product.

Nevertheless, it is important to note that a CoA does not establish safety, efficacy, therapeutic effectiveness, or suitability for human use. Instead, it serves as a quality control document that helps researchers verify the identity and purity of the peptide they are using in their laboratory investigations.

Storage and Stability of Ipamorelin

Core Peptides supplies Ipamorelin as a lyophilized (freeze-dried) powder. To maintain stability and integrity:

• Store the lyophilized powder desiccated at -20°C or below for long-term storage
• Store at 4°C for short-term storage if frequent access is required
• Avoid repeated freeze-thaw cycles
• Reconstitute only immediately before use with appropriate sterile solvents (e.g., bacteriostatic water or sterile water)
• Inject solvent slowly against the inner wall of the vial rather than directly onto the powder; do not shake
• Gently roll the vial in a circular motion to dissolve
• Once reconstituted, store at 4°C for 2-7 days or below -18°C for long-term storage
• For long-term storage, adding a carrier protein (0.1% HSA or BSA) is recommended
• Protect from light and moisture

Frequently Asked Questions About Buying Ipamorelin 5mg in Switzerland

What is Ipamorelin?

Specifically, Ipamorelin is a synthetic pentapeptide growth hormone secretagogue with the sequence Aib-His-D-2-Nal-D-Phe-Lys-NH₂. It acts as a potent and selective agonist of the ghrelin receptor (GHS-R1a).

What is Ipamorelin researched for?

Primarily, researchers study Ipamorelin for its role as a selective GHS-R1a agonist in GH secretion, metabolic regulation, and receptor pharmacology. Studies have investigated its effects on GH release, muscle preservation, bone density, and metabolic regulation.

How does Ipamorelin work?

Mechanistically, Ipamorelin binds to and activates GHS-R1a, a GPCR on pituitary somatotrophs and hypothalamic neurons. This triggers Gαq/11 signaling, activating PLC, increasing intracellular calcium, and promoting GH exocytosis from somatotrophs. Its selectivity for GH release arises from biased agonism at the receptor.

What is the amino acid sequence of Ipamorelin?

The amino acid sequence is Aib-His-D-2-Nal-D-Phe-Lys-NH₂.

What is the molecular weight of Ipamorelin?

The molecular weight is 711.85 g/mol.

What is the molecular formula of Ipamorelin?

The molecular formula is C₃₈H₄₉N₉O₅.

What is the CAS number of Ipamorelin?

The CAS number is 170851-70-4.

Is Ipamorelin synthetic?

Yes, Ipamorelin is a synthetic peptide produced through solid-phase peptide synthesis.

What is the half-life of Ipamorelin?

Ipamorelin has a half-life of approximately 2 hours.

How does Ipamorelin differ from other GHRPs?

Ipamorelin produces highly selective GH release with negligible cortisol or prolactin elevation, whereas other GHRPs such as GHRP-2, GHRP-6, and Hexarelin generate robust GH output alongside measurable increases in ACTH, cortisol, and prolactin.

What is Ipamorelin commonly paired with in research?

Ipamorelin is frequently used in combination with GHRH analogs such as CJC-1295 (Mod GRF 1-29) for synergistic GH release studies. The no-DAC variant of CJC-1295 is the typical pairing partner because its 30-minute half-life matches Ipamorelin’s roughly 2-hour half-life, preserving a pulsatile pattern.

Where can I buy Ipamorelin 5mg in Switzerland?

You can buy Ipamorelin 5mg in Switzerland from Core Peptides, a trusted research peptide supplier serving the Swiss scientific community.

How should researchers evaluate Ipamorelin quality?

Researchers should look for identity confirmation via mass spectrometry, purity data from HPLC, batch traceability, and a Certificate of Analysis.

Related Research Compounds

Researchers interested in Ipamorelin may also find the following related compounds relevant to their work:

• CJC-1295 (Mod GRF 1-29) — A GHRH analog commonly paired with Ipamorelin for synergistic GH release and pulsatile secretion studies.
• GHRP-2 — A GHRP researched for potent GH release and diagnostic applications.
• GHRP-6 — A GHRP researched for GH release and appetite stimulation studies.
• Hexarelin — A GHRP researched for potent GH release and cardioprotective effects via CD36 binding.

Explore Growth Hormone Peptides

Ipamorelin belongs to the Growth Hormone Peptides category of research compounds. Growth Hormone Peptides products are studied for their potential roles in GH axis signaling, metabolic regulation, and growth-related pathways. Generally, researchers who buy Ipamorelin 5mg in Switzerland often pair it with related compounds in this category to explore complementary pathways in GH research and metabolic studies.

Explore Growth Hormone Blends

Researchers studying multi-peptide GH axis signaling and synergistic GH release may also find relevant compounds in the Growth Hormone Blends subcategory. Ipamorelin’s selective GHS-R1a agonism makes it a valuable component for investigating receptor pharmacology and convergent GH signaling.

Explore Muscle & Performance

Researchers studying muscle preservation, recovery, and performance-related mechanisms may also find relevant compounds in the Muscle & Performance category. Ipamorelin’s effects on GH-dependent anabolic signaling make it a valuable tool for investigating muscle function and recovery.

Further Research

For researchers seeking to deepen their understanding of Ipamorelin and its research applications, the following areas may warrant further investigation:

• The relationship between Ipamorelin-mediated GHS-R1a activation and specific downstream signaling pathways in different cell types
• Comparative studies between Ipamorelin and other GHRPs in various GH axis and metabolic models
• The potential for Ipamorelin’s selective GH release profile to provide insights into isolated GH effects without adrenal axis activation
• Mechanistic studies on Ipamorelin’s biased agonism at the ghrelin receptor and its functional consequences for GH secretion
• Exploration of Ipamorelin’s effects on different tissue systems beyond the GH axis

Research Disclaimer

Researchers must not use it for human consumption, injection, or any form of therapeutic application. Moreover, this product is not a medicine, pharmaceutical, or medical device. Furthermore, Swissmedic, the FDA, EMA, or any other regulatory authority have not approved it for human use. Researchers should consult Swissmedic for applicable regulations and guidance on research peptide handling in Switzerland.

Generally, the information provided on this page is for educational and scientific reference purposes only. Therefore, it does not constitute medical advice, treatment recommendations, or dosing instructions. Ultimately, researchers bear the responsibility for ensuring that their use of this product complies with all applicable laws, regulations, and institutional guidelines.