Decapeptide-12 (200MG)

What Is Decapeptide-12 and Why Buy It for Research?

Buy Decapeptide-12 200mg in Switzerland for research into melanogenesis, tyrosinase inhibition, and hyperpigmentation disorders. Specifically, Decapeptide-12 (also known as Lumixyl) is a synthetic oligopeptide composed of ten amino acids with the sequence H-Tyr-Arg-Ser-Arg-Lys-Tyr-Ser-Ser-Trp-Tyr-OH (one-letter code: YRSRKYSSWY). Stanford University dermatology researchers developed this peptide as a targeted inhibitor of tyrosinase, the rate-limiting enzyme in the melanin biosynthesis pathway.

In scientific research, Decapeptide-12 serves as a molecular tool for studying melanogenesis, pigmentation regulation, and tyrosinase enzyme inhibition. Researchers consider this peptide particularly valuable for investigating hyperpigmentation disorders such as melasma, post-inflammatory hyperpigmentation (PIH), and photodamage. Furthermore, Core Peptides supplies Decapeptide-12 as a lyophilized powder in a 200mg format exclusively for laboratory use. Therefore, researchers seeking to source this compound for their work will find it readily available when they buy Decapeptide-12 200mg in Switzerland.

Decapeptide-12 Research Overview: Buy Decapeptide-12 200mg in Switzerland for Melanogenesis Studies

Centrally, research into Decapeptide-12 has focused on its function as a potent and selective inhibitor of tyrosinase. Endogenously, tyrosinase is a copper-containing enzyme that catalyzes the first two rate-limiting steps in melanin production within the melanosomes of melanocytes. These steps involve the hydroxylation of L-tyrosine to L-DOPA and the subsequent oxidation of L-DOPA to dopaquinone.

Decapeptide-12 acts as a competitive inhibitor of tyrosinase, binding to the enzyme’s active site and preventing the conversion of L-tyrosine to L-DOPA, effectively halting the melanin synthesis pathway. Significantly, Decapeptide-12 demonstrates approximately 17 times greater potency in inhibiting tyrosinase compared to hydroquinone, the long-standing benchmark skin-lightening agent.

Notably, Decapeptide-12 achieves this potent inhibition without causing cytotoxicity to melanocytes, suggesting a more targeted and less damaging approach to depigmentation research. Reports indicate that treatment with 100 µM Decapeptide-12 produces a 27-43% reduction in melanin content over 7 days in cultured melanocytes, with 25-35% tyrosinase inhibition. Additionally, Decapeptide-12 upregulates the transcriptional level of SIRT, a protein associated with cellular longevity and stress resistance. Accordingly, researchers who buy Decapeptide-12 200mg in Switzerland from Core Peptides can support their investigations into tyrosinase inhibition, melanogenesis regulation, and pigmentation disorder models.

How Does Decapeptide-12 Work in Research?

Mechanistically, Decapeptide-12’s proposed action involves functioning as a competitive inhibitor of tyrosinase through direct enzyme binding.

Tyrosinase Inhibition

Decapeptide-12 binds to the active site of tyrosinase, preventing the conversion of L-tyrosine to L-DOPA and the subsequent oxidation of L-DOPA to dopaquinone. This competitive inhibition effectively halts the melanogenesis cascade. Furthermore, quantitative data show that Decapeptide-12 exhibits an IC50 of 40 µM against mushroom tyrosinase and a dissociation constant (Kd) of 61.1 µM for its interaction with the C-terminal residue of tyrosinase.

Reduction of Melanin Content

By inhibiting tyrosinase activity, Decapeptide-12 leads to a reduction in melanin synthesis within melanocytes. Studies demonstrate that treatment with 100 µM Decapeptide-12 results in a 27-43% reduction in melanin content over 7 days in cultured melanocytes. Moreover, this melanin-reducing effect is achieved without inducing cytotoxicity, distinguishing it from other depigmenting agents.

Gene Expression Modulation

Beyond direct enzyme inhibition, Decapeptide-12 upregulates the transcriptional level of SIRT (sirtuin), a protein involved in cellular longevity and stress resistance. This suggests that Decapeptide-12 may have broader biological effects beyond melanogenesis, including potential applications in senescence and inflammation research.

Selective Targeting

Unlike hydroquinone, which acts through a more complex and less specific mechanism involving reactive oxygen species and cytotoxicity, Decapeptide-12 modulates melanin production without inducing cytotoxicity in melanocytes. Consequently, this selectivity makes it a valuable tool for researchers studying pigmentation pathways without the confounding effects of cell damage.

Why Is Decapeptide-12 Studied in Switzerland?

Primarily, researchers study Decapeptide-12 because it represents a well-characterized oligopeptide that enables investigation of tyrosinase inhibition, melanogenesis regulation, and hyperpigmentation research. In fact, this compound offers a focused tool for studying the molecular mechanisms underlying pigmentation disorders, melanocyte function, and pigmentation pathway modulation.

Research has demonstrated Decapeptide-12’s relevance across multiple domains. For example, Decapeptide-12 has been evaluated in several open-label studies for the treatment of facial hyperpigmentation. Its primary mechanism is the competitive inhibition of tyrosinase, which blocks the conversion of L-tyrosine to L-DOPA.

Notably, Decapeptide-12 is approximately 17 times more potent than hydroquinone, the gold-standard depigmenting agent. However, unlike hydroquinone, it does not cause cytotoxicity to melanocytes. This favorable safety profile, combined with its potent activity, makes Decapeptide-12 a promising candidate for dermatological research. Furthermore, Decapeptide-12 has demonstrated efficacy in reducing melanin content without the adverse effects associated with traditional depigmenting agents. Ultimately, researchers who buy Decapeptide-12 200mg in Switzerland gain access to a comprehensive research tool for investigating melanogenesis, pigmentation disorders, and tyrosinase inhibition.

Decapeptide-12 Research Areas in Laboratory Studies

Research Area	Focus	Evidence Level
Melanogenesis Research	Tyrosinase inhibition, melanin synthesis, pigmentation regulation	Mechanistic / In Vitro
Hyperpigmentation Disorders	Melasma, PIH, photodamage, pigmentation models	Clinical / In Vivo
Tyrosinase Enzyme Studies	Competitive inhibition, enzyme kinetics, binding affinity	Mechanistic / In Vitro
Senescence Research	SIRT upregulation, cellular longevity, aging pathways	Mechanistic / In Vitro
Anti-Inflammatory Research	Inflammation modulation, melanogenesis-inflammation crosstalk	Emerging Research
Dermatological Research	Skin pigmentation, topical applications, skin lightening	Clinical / In Vivo

Decapeptide-12 Compared With Related Research Compounds

Compound	Research Focus	Mechanism / Target	Key Difference
Decapeptide-12	Melanogenesis, hyperpigmentation, tyrosinase inhibition	Competitive tyrosinase inhibitor (IC50: 40 µM)	10-amino acid peptide; 17x more potent than hydroquinone
Hydroquinone	Skin lightening, hyperpigmentation	Tyrosinase inhibitor with ROS-mediated cytotoxicity	Small molecule; 17x less potent; cytotoxic to melanocytes
Kojic Acid	Hyperpigmentation, skin lightening	Tyrosinase inhibitor (chelates copper)	Small molecule; different mechanism; less potent
Arbutin	Hyperpigmentation, skin lightening	Tyrosinase inhibitor (hydroquinone derivative)	Small molecule; glycosylated hydroquinone; less potent

Comparatively, Decapeptide-12 differs from traditional depigmenting agents in its mechanism and safety profile. On the one hand, hydroquinone inhibits tyrosinase through a complex mechanism involving reactive oxygen species and is cytotoxic to melanocytes. On the other hand, Decapeptide-12 acts as a selective competitive inhibitor without inducing cytotoxicity. In contrast, kojic acid and arbutin are small molecules with different mechanisms of action and lower potency.

Research Applications for Decapeptide-12 in Switzerland

Scientists have investigated Decapeptide-12 across several research domains:

• Melanogenesis Research: Researchers use Decapeptide-12 to study tyrosinase inhibition, melanin synthesis pathways, and pigmentation regulation in melanocyte cultures.
• Hyperpigmentation Studies: Investigations have explored Decapeptide-12’s effects in models of melasma, post-inflammatory hyperpigmentation, and photodamage.
• Tyrosinase Enzyme Studies: The peptide serves as a tool for studying enzyme kinetics, competitive inhibition, and binding affinity at the tyrosinase active site.
• Senescence Research: Studies have examined Decapeptide-12’s effects on SIRT upregulation and cellular longevity pathways.
• Dermatological Research: Decapeptide-12 has been evaluated in open-label clinical studies for the treatment of facial hyperpigmentation.
• Inflammation Research: Emerging studies have explored the crosstalk between melanogenesis and inflammatory pathways.

Evidently, researchers who buy Decapeptide-12 200mg in Switzerland gain a valuable addition to any laboratory toolkit focused on melanogenesis, pigmentation research, and dermatological studies.

Decapeptide-12 Product Specifications

Specification	Details
Product Name	Decapeptide-12 (Lumixyl)
Alternative Names	Lumixyl, Decapeptide-12, YRSRKYSSWY
Amount	200mg
Form	Lyophilized powder
Purity	Not verified (≥96% HPLC purity reported by some suppliers)
Amino Acid Sequence	H-Tyr-Arg-Ser-Arg-Lys-Tyr-Ser-Ser-Trp-Tyr-OH
Sequence (1-letter)	YRSRKYSSWY
Peptide Length	10 amino acids (oligopeptide)
Molecular Formula	C₆₅H₉₀N₁₈O₁₇
Molecular Weight	1395.5 g/mol (free base)
CAS Number	137665-91-9
IC50 (Mushroom Tyrosinase)	40 µM (competitive inhibitor)
Kd (Tyrosinase C-terminal)	61.1 µM
Research Category	Skin, Hair & Beauty / Cellular Research & Signaling
Research Use	Laboratory research use only
CoA	Available upon request (not verified)
Storage	Lyophilized powder should be stored desiccated at -20°C or below, protected from light
Solubility	Soluble in water and polar organic solvents

How to Evaluate Decapeptide-12 Quality for Research

When sourcing Decapeptide-12 peptide for laboratory research, researchers should consider several quality indicators:

• Identity Confirmation: Analytical techniques such as mass spectrometry should confirm the compound’s molecular weight (1395.5 g/mol) and sequence (H-Tyr-Arg-Ser-Arg-Lys-Tyr-Ser-Ser-Trp-Tyr-OH).
• Purity Assessment: High-performance liquid chromatography (HPLC) should verify purity, with ≥96% considered standard for research-grade material.
• Batch Traceability: Lot numbers and batch information enable researchers to track specific production runs.
• Certificate of Analysis: A CoA should accompany the product, detailing analytical testing results including HPLC purity and identity confirmation.
• Labeling Accuracy: Proper labeling should clearly indicate the product name, amount (200mg), sequence, molecular formula, CAS number, and storage recommendations.
• Storage Conditions: Appropriate storage at -20°C or below in desiccated, dark conditions helps maintain peptide stability.

Understanding the Certificate of Analysis

Typically, a Certificate of Analysis (CoA) accompanies research peptides and provides information about the specific batch’s analytical testing. For example, a CoA may include product identity confirmation, purity percentage as determined by HPLC, batch or lot number for traceability, analytical methods used (e.g., mass spectrometry, HPLC), and a physical description of the product.

Nevertheless, it is important to note that a CoA does not establish safety, efficacy, therapeutic effectiveness, or suitability for human use. Instead, it serves as a quality control document that helps researchers verify the identity and purity of the peptide they are using in their laboratory investigations.

Storage and Stability of Decapeptide-12

Core Peptides supplies Decapeptide-12 as a lyophilized (freeze-dried) powder. To maintain stability and integrity:

• Store the lyophilized powder desiccated at -20°C or below for long-term storage
• Store at 4°C for short-term storage if frequent access is required
• Avoid repeated freeze-thaw cycles
• Weigh under dry conditions; the peptide is hygroscopic
• Reconstitute only immediately before use with appropriate sterile solvents (sterile water or buffered aqueous solutions)
• Inject solvent slowly against the inner wall of the vial; avoid vigorous agitation during dissolution
• Filter sterilize if required (e.g., 0.22 µm) immediately prior to use
• Aliquot and store reconstituted solutions at -20°C or below to minimize degradation
• Protect from light and moisture; prolonged exposure to light, elevated temperature, or aqueous environments may reduce stability

Frequently Asked Questions About Buying Decapeptide-12 200mg in Switzerland

What is Decapeptide-12?

Specifically, Decapeptide-12 (Lumixyl) is a synthetic oligopeptide with the amino acid sequence H-Tyr-Arg-Ser-Arg-Lys-Tyr-Ser-Ser-Trp-Tyr-OH (YRSRKYSSWY). It is a competitive inhibitor of tyrosinase developed by Stanford University dermatology researchers.

What is Decapeptide-12 researched for?

Primarily, researchers study Decapeptide-12 for its role as a tyrosinase inhibitor in melanogenesis, hyperpigmentation disorders, and pigmentation research. Studies have investigated its effects on melanin synthesis, SIRT upregulation, and dermatological applications.

How does Decapeptide-12 work?

Mechanistically, Decapeptide-12 functions as a competitive inhibitor of tyrosinase, binding to the enzyme’s active site and preventing the conversion of L-tyrosine to L-DOPA, thereby halting melanin synthesis. It has an IC50 of 40 µM against mushroom tyrosinase and a Kd of 61.1 µM.

What is the amino acid sequence of Decapeptide-12?

The amino acid sequence is H-Tyr-Arg-Ser-Arg-Lys-Tyr-Ser-Ser-Trp-Tyr-OH (one-letter code: YRSRKYSSWY).

What is the molecular weight of Decapeptide-12?

The molecular weight is approximately 1395.5 g/mol (free base).

What is the molecular formula of Decapeptide-12?

The molecular formula is C₆₅H₉₀N₁₈O₁₇.

What is the CAS number of Decapeptide-12?

The CAS number is 137665-91-9.

Is Decapeptide-12 synthetic?

Yes, Decapeptide-12 is a synthetic peptide produced through solid-phase peptide synthesis (SPPS).

How does Decapeptide-12 compare to hydroquinone?

Decapeptide-12 is approximately 17 times more potent than hydroquinone in inhibiting tyrosinase and does not cause cytotoxicity to melanocytes.

What research exists on Decapeptide-12?

Research on Decapeptide-12 includes in vitro studies demonstrating tyrosinase inhibition (IC50: 40 µM) and melanin content reduction (27-43% at 100 µM), open-label clinical studies for facial hyperpigmentation, and investigations into SIRT upregulation.

Is Decapeptide-12 approved as a medicine?

No. Regulatory authorities have not approved Decapeptide-12 as a medicine, pharmaceutical, or therapeutic agent. It is a research tool for laboratory use only.

Is Decapeptide-12 intended for human use?

No. Decapeptide-12 is intended for laboratory research use only and is not for human consumption, injection, or therapeutic application.

Where can I buy Decapeptide-12 200mg in Switzerland?

You can buy Decapeptide-12 200mg in Switzerland from Core Peptides, a trusted research peptide supplier serving the Swiss scientific community.

How should researchers evaluate Decapeptide-12 quality?

Researchers should look for identity confirmation via mass spectrometry, purity data from HPLC, batch traceability, and a Certificate of Analysis.

Related Research Compounds

Researchers interested in Decapeptide-12 may also find the following related compounds relevant to their work:

• GHK-Cu — A copper-binding peptide researched for skin regeneration, wound healing, and anti-aging applications.
• AHK-Cu — A copper tripeptide researched for hair follicle and dermal papilla cell studies.
• BPC-157 — A peptide researched for tissue healing, gastrointestinal protection, and angiogenesis.
• TB-500 — A Thymosin Beta-4 fragment researched for tissue repair and wound healing.

Explore Skin, Hair & Beauty

Decapeptide-12 belongs to the Skin, Hair & Beauty category of research compounds. Skin, Hair & Beauty products are studied for their potential roles in dermatological research, pigmentation modulation, and skin health. Generally, researchers who buy Decapeptide-12 200mg in Switzerland often pair it with related compounds in this category to explore complementary pathways in pigmentation and skin research.

Explore Cellular Research & Signaling

Researchers studying melanogenesis pathways, enzyme inhibition, and cellular signaling may also find relevant compounds in the Cellular Research & Signaling category. Decapeptide-12’s interactions with tyrosinase and SIRT make it a valuable tool for investigating cellular signaling and pigmentation regulation.

Further Research

For researchers seeking to deepen their understanding of Decapeptide-12 and its research applications, the following areas may warrant further investigation:

• The relationship between Decapeptide-12-mediated tyrosinase inhibition and specific downstream effects on melanogenesis pathways
• Comparative studies between Decapeptide-12 and other tyrosinase inhibitors in various pigmentation models
• The potential role of Decapeptide-12 in modulating SIRT expression and cellular senescence pathways
• Mechanistic studies on Decapeptide-12’s interaction with the tyrosinase active site and its binding kinetics
• Exploration of Decapeptide-12’s effects on different cell types and tissue systems beyond melanocytes

Research Disclaimer

Decapeptide-12 is a research peptide supplied for laboratory research use only. Researchers must not use it for human consumption, injection, or any form of therapeutic application. Moreover, this product is not a medicine, pharmaceutical, or medical device. Furthermore, Swissmedic, the FDA, EMA, or any other regulatory authority have not approved it for human use. Researchers should consult Swissmedic for applicable regulations and guidance on research peptide handling in Switzerland.

Generally, the information provided on this page is for educational and scientific reference purposes only. Therefore, it does not constitute medical advice, treatment recommendations, or dosing instructions. Ultimately, researchers bear the responsibility for ensuring that their use of this product complies with all applicable laws, regulations, and institutional guidelines.

Finally, all research involving peptides should be conducted by qualified personnel in appropriate laboratory settings with proper safety protocols.