Gonadorelin (GnRH) (10MG)

What Is Gonadorelin and Why Buy It for Research?

Buy Gonadorelin 10mg in Switzerland for research into reproductive endocrinology, hypothalamic-pituitary-gonadal (HPG) axis signaling, and GnRH receptor pharmacology. Specifically, Gonadorelin (also known as GnRH, LHRH, Luliberin, or Gonadotropin-Releasing Hormone) is a synthetic decapeptide composed of ten amino acids with the sequence Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH₂. It is identical to the endogenous hypothalamic hormone that serves as the primary regulator of the reproductive axis in mammals.

Gonadorelin has a molecular weight of 1182.31 g/mol and the molecular formula C₅₅H₇₅N₁₇O₁₃. The peptide is available as a free base (CAS 33515-09-2) and as an acetate salt (CAS 34973-08-5). In scientific research, Gonadorelin serves as the standard native agonist for studying GnRH receptor signaling, pituitary gonadotrope function, and HPG axis regulation. Furthermore, Core Peptides supplies Gonadorelin as a lyophilized powder in a 10mg format exclusively for laboratory use. Therefore, researchers seeking to source this compound for their work will find it readily available when they buy Gonadorelin 10mg in Switzerland.

Gonadorelin Research Overview: Buy Gonadorelin 10mg in Switzerland for GnRH Receptor Studies

Centrally, research into Gonadorelin has focused on its function as the primary hypothalamic regulator of the reproductive axis. Gonadorelin is produced by neuroendocrine cells within the hypothalamus and is secreted in a pulsatile manner. The peptide binds to and activates the GnRH receptor (GnRHR), a G-protein coupled receptor (GPCR) expressed on gonadotrope cells of the anterior pituitary.

Gonadorelin induces the synthesis and secretion of the two key gonadotropins—luteinizing hormone (LH) and follicle-stimulating hormone (FSH)—from the anterior pituitary. This native decapeptide sequence and its ~4-minute half-life are essential for physiologic pulsatile LH/FSH secretion. After a transient increase, continuous administration of Gonadorelin results in downregulation of LH and FSH levels followed by a suppression of ovarian and testicular steroid biosynthesis.

The GnRH receptor is a critical target for research into reproductive disorders such as infertility. Gonadorelin is also used in veterinary medicine to treat animals with infertility and to synchronize estrus. Accordingly, researchers who buy Gonadorelin 10mg in Switzerland from Core Peptides can support their investigations into GnRH receptor signaling, gonadotropin regulation, and HPG axis function.

How Does Gonadorelin Work in Research?

Mechanistically, Gonadorelin’s proposed action involves functioning as a native GnRH receptor agonist that activates Gq/11-coupled signaling to stimulate gonadotropin release. The peptide operates through a well-characterized mechanism involving several key steps.

GnRH Receptor Binding

Gonadorelin binds to and activates the GnRH receptor (GnRHR) on pituitary gonadotrope cells. The binding affinity (Ki) of Gonadorelin for the native GnRH receptor is approximately 13 nM. This binding event initiates a conformational change in the receptor, leading to the activation of downstream signaling pathways that are critical for gonadotropin synthesis and secretion.

Intracellular Signaling Cascade

The primary signaling pathway involves the coupling of activated GnRHR to the Gαq/11 subunit of the heterotrimeric G protein. This activation stimulates phospholipase C (PLC), which hydrolyzes phosphatidylinositol 4,5-bisphosphate (PIP2) into two key second messengers: inositol trisphosphate (IP3) and diacylglycerol (DAG). IP3 triggers the release of stored calcium (Ca²⁺) from the endoplasmic reticulum, and this sharp increase in intracellular calcium is critical for the exocytosis of gonadotropin-containing vesicles. Additionally, DAG activates protein kinase C (PKC), contributing to downstream cellular responses.

Gonadotropin Release

Gonadorelin stimulates the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the anterior pituitary. The initial response of gonadotropes to GnRH involves the Gs/cAMP pathway, providing transmission of GnRHR signals to the nucleus with consequent cell activation. This dual signaling mechanism underlies the potent gonadotropin-releasing activity of Gonadorelin.

Pulsatile versus Continuous Administration

The physiologic action of Gonadorelin is pulsatile, with a half-life of approximately 2-10 minutes. Pulsatile administration stimulates gonadotropin release, while continuous administration leads to receptor downregulation and suppression of gonadotropin secretion. This biphasic response is fundamental to understanding GnRH receptor pharmacology and is essential for research into reproductive hormone regulation.

Why Is Gonadorelin Studied in Switzerland?

Primarily, researchers study Gonadorelin because it represents the native GnRH decapeptide that enables investigation of reproductive axis signaling, gonadotropin regulation, and GnRH receptor pharmacology. In fact, this compound offers a focused tool for studying the molecular mechanisms underlying HPG axis function, fertility regulation, and reproductive endocrinology.

Research has demonstrated Gonadorelin’s relevance across multiple domains. Gonadorelin is the only agonist that replicates the physiologic 2-10 minute half-life essential for pulsatile pituitary challenge. Diagnostic laboratories running GnRH stimulation tests rely on Gonadorelin because superagonists cannot substitute without altering LH peak kinetics and invalidating established clinical cutoffs.

Furthermore, Gonadorelin has been extensively studied in veterinary research for estrus synchronization, ovulation induction, and treatment of ovarian cysts. Studies in river buffalo have demonstrated that 100 μg of Gonadorelin is the most effective dose to induce ovulation followed by the emergence of a new follicular wave. Ultimately, researchers who buy Gonadorelin 10mg in Switzerland gain access to a comprehensive research tool for investigating GnRH receptor signaling, gonadotropin regulation, and reproductive endocrinology.

Gonadorelin Research Areas in Laboratory Studies

Research Area	Focus	Evidence Level
GnRH Receptor Pharmacology	Receptor binding, Gq/11 signaling, calcium mobilization, receptor desensitization	Mechanistic / In Vitro
Gonadotropin Secretion	LH and FSH release, pulsatile secretion, gonadotrope function	Mechanistic / In Vivo
Hypothalamic-Pituitary-Gonadal Axis	HPG axis regulation, feedback mechanisms, reproductive endocrinology	Preclinical / Clinical
Fertility Research	Ovulation induction, gametogenesis, reproductive function	Preclinical / Clinical
Veterinary Reproduction	Estrus synchronization, ovarian cysts, fertility treatment in livestock	Veterinary
Diagnostic Testing	GnRH stimulation tests, hypothalamic-pituitary function assessment	Clinical

Gonadorelin Compared With Related Research Compounds

Compound	Research Focus	Mechanism / Target	Key Difference
Gonadorelin (GnRH)	Native GnRH receptor agonist, gonadotropin release, HPG axis	GnRHR agonist (Gq/11, Gs/cAMP signaling)	Native decapeptide; ~4 min half-life; physiologic pulsatile response
Leuprolide (GnRH Superagonist)	Continuous GnRH receptor activation, downregulation	GnRHR agonist with enhanced receptor binding	Sustained receptor activation; long half-life; therapeutic applications
Buserelin	GnRH receptor agonist, reproductive disorders	GnRHR agonist	Superagonist; used in reproductive disorder research
Cetrorelix (GnRH Antagonist)	GnRH receptor blockade, rapid suppression of gonadotropins	GnRHR antagonist	Receptor antagonist; different mechanism and application

Comparatively, Gonadorelin differs from GnRH superagonists and antagonists in its pharmacokinetic profile and research applications. On the one hand, Gonadorelin is the native decapeptide with a short half-life of approximately 2-10 minutes, making it essential for physiologic pulsatile studies and diagnostic testing. On the other hand, superagonists such as Leuprolide have extended half-lives (≥3 hours) and are used for sustained receptor activation and downregulation studies. In contrast, GnRH antagonists like Cetrorelix block the receptor directly and are used for rapid suppression of gonadotropin secretion.

Research Applications for Gonadorelin in Switzerland

Scientists have investigated Gonadorelin across several research domains:

• GnRH Receptor Pharmacology: Researchers use Gonadorelin to study native receptor binding, Gq/11 signaling, calcium mobilization, and receptor desensitization.
• Gonadotropin Secretion Studies: The peptide is employed to investigate LH and FSH release, pulsatile secretion dynamics, and gonadotrope function.
• Reproductive Endocrinology: Studies have examined Gonadorelin’s effects on the HPG axis, feedback mechanisms, and reproductive hormone regulation.
• Fertility Research: Gonadorelin is used to study ovulation induction, gametogenesis, and reproductive function in preclinical and clinical models.
• Veterinary Reproduction: The peptide has been investigated for estrus synchronization, ovarian cyst treatment, and fertility management in livestock.
• Diagnostic Testing: Gonadorelin is the standard agonist for GnRH stimulation tests to assess hypothalamic-pituitary function.

Evidently, researchers who buy Gonadorelin 10mg in Switzerland gain a valuable addition to any laboratory toolkit focused on reproductive endocrinology, GnRH receptor pharmacology, and HPG axis research.

Gonadorelin Product Specifications

Specification	Details
Product Name	Gonadorelin (GnRH, LHRH)
Alternative Names	GnRH, LHRH, Luliberin, Gonadotropin-Releasing Hormone, LH-RH, LHFSH Releasing Hormone
Amount	10mg
Form	Lyophilized powder
Purity	Not verified (≥98% HPLC purity reported by some suppliers)
Amino Acid Sequence	Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH₂
Peptide Length	10 amino acids (decapeptide)
Molecular Formula	C₅₅H₇₅N₁₇O₁₃
Molecular Weight	1182.31 g/mol
CAS Number (Free Base)	33515-09-2
CAS Number (Acetate)	34973-08-5
PubChem CID	9809
Half-Life	Approximately 2-10 minutes
Receptor Binding Affinity (Ki)	~13 nM (native GnRHR)
Research Category	Fertility & Hormone Research / Sexual Health
Research Use	Laboratory research use only
CoA	Available upon request (not verified)
Storage	Lyophilized powder should be stored desiccated at -20°C or below, protected from light
Solubility	Soluble in water and bacteriostatic water

How to Evaluate Gonadorelin Quality for Research

When sourcing Gonadorelin peptide for laboratory research, researchers should consider several quality indicators:

• Identity Confirmation: Analytical techniques such as mass spectrometry should confirm the compound’s molecular weight (1182.31 g/mol) and sequence (Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH₂).
• Purity Assessment: High-performance liquid chromatography (HPLC) should verify purity, with ≥98% considered standard for research-grade material.
• Batch Traceability: Lot numbers and batch information enable researchers to track specific production runs.
• Certificate of Analysis: A CoA should accompany the product, detailing analytical testing results including HPLC purity and identity confirmation.
• Labeling Accuracy: Proper labeling should clearly indicate the product name, amount (10mg), sequence, molecular formula, CAS number, and storage recommendations.
• Storage Conditions: Appropriate storage at -20°C or below in desiccated, dark conditions helps maintain peptide stability.

Understanding the Certificate of Analysis

Typically, a Certificate of Analysis (CoA) accompanies research peptides and provides information about the specific batch’s analytical testing. For example, a CoA may include product identity confirmation, purity percentage as determined by HPLC, batch or lot number for traceability, analytical methods used (e.g., mass spectrometry, HPLC), and a physical description of the product.

Nevertheless, it is important to note that a CoA does not establish safety, efficacy, therapeutic effectiveness, or suitability for human use. Instead, it serves as a quality control document that helps researchers verify the identity and purity of the peptide they are using in their laboratory investigations.

Storage and Stability of Gonadorelin

Core Peptides supplies Gonadorelin as a lyophilized (freeze-dried) powder. To maintain stability and integrity:

• Store the lyophilized powder desiccated at -20°C or below for long-term storage
• Store at 4°C for short-term storage if frequent access is required
• Avoid repeated freeze-thaw cycles
• Reconstitute only immediately before use with appropriate sterile solvents (e.g., bacteriostatic water or sterile water)
• Inject solvent slowly against the inner wall of the vial rather than directly onto the powder; do not shake
• Gently roll the vial in a circular motion to dissolve
• Once reconstituted, refrigerate at 2°C to 8°C and utilize promptly
• Protect from light and moisture

Frequently Asked Questions About Buying Gonadorelin 10mg in Switzerland

What is Gonadorelin?

Specifically, Gonadorelin (GnRH, LHRH) is a synthetic decapeptide identical to the endogenous hypothalamic gonadotropin-releasing hormone with the sequence Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH₂. It is the primary regulator of the reproductive axis in mammals.

What is Gonadorelin researched for?

Primarily, researchers study Gonadorelin for its role as the native GnRH receptor agonist in reproductive endocrinology, HPG axis signaling, and gonadotropin regulation. Studies have investigated its effects on LH and FSH release, fertility, and GnRH receptor pharmacology.

How does Gonadorelin work?

Mechanistically, Gonadorelin binds to and activates the GnRH receptor on pituitary gonadotrope cells, triggering Gq/11 signaling, phospholipase C activation, calcium mobilization, and the release of LH and FSH.

What is the amino acid sequence of Gonadorelin?

The amino acid sequence is Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH₂.

What is the molecular weight of Gonadorelin?

The molecular weight is 1182.31 g/mol.

What is the molecular formula of Gonadorelin?

The molecular formula is C₅₅H₇₅N₁₇O₁₃.

What is the CAS number of Gonadorelin?

The CAS number for the free base is 33515-09-2. The acetate salt is CAS 34973-08-5.

Is Gonadorelin synthetic?

Yes, Gonadorelin is a synthetic peptide produced through solid-phase peptide synthesis.

How does Gonadorelin differ from GnRH superagonists?

Gonadorelin is the native decapeptide with a short half-life (2-10 minutes) and produces physiologic pulsatile LH/FSH responses. Superagonists such as Leuprolide have extended half-lives and are used for sustained receptor activation and downregulation studies.

What is the half-life of Gonadorelin?

Gonadorelin has a short half-life of approximately 2-10 minutes.

Where can I buy Gonadorelin 10mg in Switzerland?

You can buy Gonadorelin 10mg in Switzerland from Core Peptides, a trusted research peptide supplier serving the Swiss scientific community.

How should researchers evaluate Gonadorelin quality?

Researchers should look for identity confirmation via mass spectrometry, purity data from HPLC, batch traceability, and a Certificate of Analysis.

Related Research Compounds

Researchers interested in Gonadorelin may also find the following related compounds relevant to their work:

• Leuprolide — A GnRH superagonist researched for sustained receptor activation, downregulation, and reproductive disorder models.
• Buserelin — A GnRH superagonist researched for reproductive endocrinology and fertility studies.
• Cetrorelix — A GnRH antagonist researched for rapid gonadotropin suppression and reproductive research.
• Kisspeptin-10 — A peptide that stimulates GnRH release, researched for fertility and reproductive axis regulation.

Explore Fertility & Hormone Research

Gonadorelin belongs to the Fertility & Hormone Research category of research compounds. Fertility & Hormone Research products are studied for their potential roles in reproductive endocrinology, hormone regulation, and fertility research. Generally, researchers who buy Gonadorelin 10mg in Switzerland often pair it with related compounds in this category to explore complementary pathways in reproductive research and endocrine signaling.

Explore Sexual Health

Researchers studying reproductive function, hormonal regulation, and sexual health may also find relevant compounds in the Sexual Health category. Gonadorelin’s role in the HPG axis and gonadotropin regulation makes it a valuable tool for investigating reproductive and sexual health research.

Further Research

For researchers seeking to deepen their understanding of Gonadorelin and its research applications, the following areas may warrant further investigation:

• The relationship between Gonadorelin-mediated GnRH receptor activation and specific downstream signaling pathways in gonadotrope cells
• Comparative studies between Gonadorelin and GnRH superagonists in various reproductive and endocrine models
• The potential for Gonadorelin’s pulsatile administration to provide insights into physiologic gonadotropin regulation
• Mechanistic studies on Gonadorelin’s interaction with the GnRH receptor and its functional consequences for LH and FSH secretion
• Exploration of Gonadorelin’s effects on different cell types and tissue systems beyond the reproductive axis

Research Disclaimer

Researchers must not use it for human consumption, injection, or any form of therapeutic application outside approved diagnostic contexts. Moreover, this product is not a medicine, pharmaceutical, or medical device. Furthermore, Swissmedic, the FDA, EMA, or any other regulatory authority have not approved it for therapeutic human use. Researchers should consult Swissmedic for applicable regulations and guidance on research peptide handling in Switzerland.

Generally, the information provided on this page is for educational and scientific reference purposes only. Therefore, it does not constitute medical advice, treatment recommendations, or dosing instructions. Ultimately, researchers bear the responsibility for ensuring that their use of this product complies with all applicable laws, regulations, and institutional guidelines.