Epithalon (25MG)

What Is Epithalon and Why Buy It for Research?

Buy Epithalon 25mg in Switzerland for research into pineal gland function, telomerase activation, and cellular longevity pathways. Specifically, Epithalon (also known as Epitalon, AEDG, or Ala-Glu-Asp-Gly) is a synthetic tetrapeptide composed of four amino acids with the sequence Ala-Glu-Asp-Gly (AEDG). Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology developed Epithalon based on amino acid analysis of the natural pineal gland peptide preparation epithalamin.

Epithalon is the synthetic equivalent of the putative active component of epithalamin, a crude polypeptide extracted from the bovine pineal gland. In scientific research, Epithalon serves as a molecular tool for studying pineal gland regulation, telomere biology, and neuroimmunoendocrine system modulation. Researchers consider this peptide particularly valuable for investigating anti-aging mechanisms, neuroprotection, and epigenetic regulation. Furthermore, Core Peptides supplies Epithalon as a lyophilized powder in a 25mg format exclusively for laboratory use. Therefore, researchers seeking to source this compound for their work will find it readily available when they buy Epithalon 25mg in Switzerland.

Epithalon Research Overview: Buy Epithalon 25mg in Switzerland for Longevity Studies

Centrally, research into Epithalon has focused on its function as a pleiotropic bioregulator with effects on pineal gland function, telomerase activity, and cellular aging. Endogenously, the pineal gland produces melatonin and regulates circadian rhythms, playing a critical role in the neuroimmunoendocrine system. Epithalon was designed to reproduce the biological activity of the natural pineal gland peptide complex epithalamin.

Unlike conventional pharmaceutical agents that act through receptor-mediated signaling, Khavinson’s bioregulator theory proposes that Epithalon penetrates cell nuclei and interacts directly with DNA and histones, thereby modulating transcription of tissue-relevant genes. Studies have demonstrated that the AEDG peptide preferably binds with H1/6 and H1/3 histones, suggesting an epigenetic mechanism of action.

Notably, Epithalon has been shown to restore melatonin secretion in the pineal gland and exhibit strong regulatory activity at the neuroimmunoendocrine and antioxidant organism systems. A 2025 study published in Biogerontology demonstrated that Epithalon can extend telomere length in normal healthy mammalian cells through the upregulation of hTERT mRNA expression and telomerase enzyme activity. Accordingly, researchers who buy Epithalon 25mg in Switzerland from Core Peptides can support their investigations into pineal gland function, telomerase activation, and anti-aging mechanisms.

How Does Epithalon Work in Research?

Mechanistically, Epithalon’s proposed action involves functioning as a nuclear-targeting peptide that modulates gene expression through epigenetic chromatin remodeling and telomerase activation. The peptide operates through several interconnected mechanisms.

Telomerase Activation and Telomere Elongation

Epithalon’s signature mechanism is its ability to reactivate telomerase in somatic cells. Studies demonstrate that Epithalon induces expression of the catalytic subunit of telomerase (hTERT), leading to enzymatic activity and telomere elongation in human somatic cells. A 2025 study confirmed that Epithalon can extend telomere length in normal healthy mammalian cells through the upregulation of hTERT mRNA expression and telomerase enzyme activity. Consequently, this telomerase activation is considered a key mechanism underlying Epithalon’s anti-aging and geroprotective effects.

Epigenetic Regulation and Gene Expression

Epithalon modulates gene expression through epigenetic mechanisms. The AEDG peptide preferably binds with H1/6 and H1/3 histones in specific sites, suggesting that histone binding may be one of the mechanisms by which Epithalon exerts its effects. Research has shown that the AEDG peptide regulates the function of the pineal gland, the retina, and the brain. Additionally, Epithalon stimulates gene expression and protein synthesis during neurogenesis, indicating its role in neuronal differentiation and repair.

Pineal Gland and Melatonin Regulation

Epithalon restores melatonin secretion in the pineal gland and exhibits strong regulatory activity at the neuroimmunoendocrine system level. Studies have demonstrated that Epithalon administration results in decreased cathepsin D activity, suggesting modulation of lysosomal proteinase activity in the liver and kidneys. Furthermore, the peptide also influences the mitogenic activity of murine thymocytes and enhances the activity of various enzymes, including acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), and telomerase.

Neuroprotection and Retinoprotection

Epithalon has demonstrated neuroprotective and retinoprotective effects in preclinical studies. Research has shown that Epithalon exerts a retinoprotective effect in Campbell rats of various ages. Additionally, studies have examined the effects of Epithalon on the proliferative activity of retinal and pigmented epithelial cells. The peptide has also been shown to modulate immunity and hemostasis in hypophysectomized chicken and old birds.

Why Is Epithalon Studied in Switzerland?

Primarily, researchers study Epithalon because it represents a well-characterized tetrapeptide bioregulator that enables investigation of pineal gland function, telomerase activation, and anti-aging mechanisms. In fact, this compound offers a focused tool for studying the molecular mechanisms underlying cellular longevity, neuroprotection, and epigenetic regulation.

Research has demonstrated Epithalon’s relevance across multiple domains. For instance, studies have shown that Epithalon decelerates aging and suppresses the development of breast adenocarcinomas in transgenic her-2/neu mice. The peptide has demonstrated geroprotective activity and the ability to decrease experimental cancerogenesis. Furthermore, Epithalon increases longevity in animals and induces neuronal cell differentiation in retinal and human periodontal ligament stem cells.

Long-term experience has shown that Epithalon restores melatonin secretion in the pineal gland and has strong regulatory activity at the neuroimmunoendocrine and antioxidant organism systems. Ultimately, researchers who buy Epithalon 25mg in Switzerland gain access to a comprehensive research tool for investigating pineal gland function, telomerase activation, and anti-aging pathways.

Epithalon Research Areas in Laboratory Studies

Research Area	Focus	Evidence Level
Telomerase Activation	hTERT upregulation, telomere elongation, cellular senescence reversal	Mechanistic / In Vitro
Pineal Gland Function	Melatonin secretion, circadian rhythm, neuroimmunoendocrine regulation	Preclinical
Anti-Aging and Longevity	Geroprotection, lifespan extension, age-related decline modulation	Preclinical
Epigenetic Regulation	Histone binding, chromatin remodeling, gene expression modulation	Mechanistic
Neuroprotection	Retinoprotection, neuronal differentiation, CNS protection	Preclinical
Cancer Research	Tumor suppression, oncogenesis inhibition, cancer prevention	Preclinical
Immune System Modulation	Thymocyte differentiation, immunity regulation, hemostasis	Preclinical

Epithalon Compared With Related Research Compounds

Compound	Research Focus	Mechanism / Target	Key Difference
Epithalon (AEDG)	Pineal gland, telomerase activation, anti-aging	Telomerase reactivation, histone binding, gene expression	Tetrapeptide; Ala-Glu-Asp-Gly sequence; pineal-specific bioregulator
Cortagen (AEDP)	Brain and CNS, neuroprotection, nerve regeneration	Chromatin remodeling, gene expression modulation	Different target tissue; Ala-Glu-Asp-Pro sequence
Bronchogen (AEDL)	Bronchial epithelium, pulmonary research	DNA interaction, gene expression modulation	Different target tissue; Ala-Glu-Asp-Leu sequence
Cardiogen (AEDR)	Cardiac tissue, cardiomyocyte function	DNA interaction, chromatin modulation	Different target tissue; Ala-Glu-Asp-Arg sequence

Comparatively, Epithalon differs from other Khavinson peptide bioregulators in its tissue specificity and amino acid sequence. On the one hand, Epithalon (Ala-Glu-Asp-Gly) targets pineal gland function and aging-related processes, with a unique mechanism involving telomerase reactivation and telomere elongation. On the other hand, Cortagen (Ala-Glu-Asp-Pro) is specifically designed for brain and central nervous system research. In contrast, Bronchogen targets bronchial epithelium while Cardiogen focuses on cardiac tissue.

Research Applications for Epithalon in Switzerland

Scientists have investigated Epithalon across several research domains:

• Telomerase and Telomere Research: Researchers use Epithalon to study telomerase activation, hTERT upregulation, and telomere elongation in somatic cells.
• Pineal Gland Studies: Investigations have explored Epithalon’s effects on melatonin secretion, circadian rhythm regulation, and neuroimmunoendocrine system modulation.
• Anti-Aging and Longevity Research: Studies have examined Epithalon’s geroprotective effects, lifespan extension, and modulation of age-related decline.
• Epigenetic Research: Epithalon serves as a tool for studying histone binding, chromatin remodeling, and gene expression regulation.
• Neuroprotection Studies: Research has investigated Epithalon’s retinoprotective and neuroprotective effects in various preclinical models.
• Cancer Research: Studies have explored Epithalon’s tumor-suppressing effects and potential in cancer prevention models.

Evidently, researchers who buy Epithalon 25mg in Switzerland gain a valuable addition to any laboratory toolkit focused on pineal gland function, telomerase activation, and anti-aging research.

Epithalon Product Specifications

Specification	Details
Product Name	Epithalon (Epitalon)
Alternative Names	Epitalon, AEDG, Ala-Glu-Asp-Gly, Epithalamin tetrapeptide
Amount	25mg
Form	Lyophilized powder (white to off-white)
Purity	Not verified (≥98-99% HPLC purity reported by some suppliers)
Amino Acid Sequence	H-Ala-Glu-Asp-Gly-OH (AEDG)
Sequence (3-letter)	Ala-Glu-Asp-Gly
Peptide Length	4 amino acids (tetrapeptide)
Molecular Formula	C₁₄H₂₂N₄O₉
Molecular Weight	390.35 g/mol (free base)
CAS Number	307297-39-8
Research Category	Anti-Aging & Longevity / Cellular Research & Signaling
Research Use	Laboratory research use only
CoA	Available upon request (not verified)
Storage	Lyophilized powder should be stored desiccated at -20°C or below, protected from light
Solubility	Soluble in water and buffered aqueous solutions

How to Evaluate Epithalon Quality for Research

When sourcing Epithalon peptide for laboratory research, researchers should consider several quality indicators:

• Identity Confirmation: Analytical techniques such as mass spectrometry should confirm the compound’s molecular weight (390.35 g/mol) and sequence (H-Ala-Glu-Asp-Gly-OH).
• Purity Assessment: High-performance liquid chromatography (HPLC) should verify purity, with ≥98% considered standard for research-grade material.
• Batch Traceability: Lot numbers and batch information enable researchers to track specific production runs.
• Certificate of Analysis: A CoA should accompany the product, detailing analytical testing results including HPLC purity and identity confirmation.
• Labeling Accuracy: Proper labeling should clearly indicate the product name, amount (25mg), sequence, molecular formula, CAS number, and storage recommendations.
• Storage Conditions: Appropriate storage at -20°C or below in desiccated, dark conditions helps maintain peptide stability.

Understanding the Certificate of Analysis

Typically, a Certificate of Analysis (CoA) accompanies research peptides and provides information about the specific batch’s analytical testing. For example, a CoA may include product identity confirmation, purity percentage as determined by HPLC, batch or lot number for traceability, analytical methods used (e.g., mass spectrometry, HPLC), and a physical description of the product.

Nevertheless, it is important to note that a CoA does not establish safety, efficacy, therapeutic effectiveness, or suitability for human use. Instead, it serves as a quality control document that helps researchers verify the identity and purity of the peptide they are using in their laboratory investigations.

Storage and Stability of Epithalon

Core Peptides supplies Epithalon as a lyophilized (freeze-dried) powder. To maintain stability and integrity:

• Store the lyophilized powder desiccated at -20°C or below for long-term storage
• Store at 4°C for short-term storage if frequent access is required
• Avoid repeated freeze-thaw cycles
• Weigh under dry conditions; the peptide is hygroscopic
• Reconstitute only immediately before use with appropriate sterile solvents (sterile water or buffered aqueous solutions)
• Inject solvent slowly against the inner wall of the vial; avoid vigorous agitation during dissolution
• Filter sterilize if required (e.g., 0.22 µm) immediately prior to use
• Aliquot and store reconstituted solutions at -20°C or below to minimize degradation
• Protect from light and moisture; prolonged exposure to light, elevated temperature, or aqueous environments may reduce stability

Frequently Asked Questions About Buying Epithalon 25mg in Switzerland

What is Epithalon?

Specifically, Epithalon (Epitalon, AEDG) is a synthetic tetrapeptide with the amino acid sequence Ala-Glu-Asp-Gly (AEDG). It is a tissue-specific bioregulator developed by Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology as a pineal gland-specific bioregulator.

What is Epithalon researched for?

Primarily, researchers study Epithalon for its role in pineal gland function, telomerase activation, and anti-aging mechanisms. Studies have investigated its effects on telomere elongation, melatonin synthesis, neuroprotection, and epigenetic regulation.

How does Epithalon work?

Mechanistically, Epithalon functions through multiple pathways: telomerase activation via hTERT upregulation, epigenetic regulation through histone binding, pineal gland modulation via melatonin secretion restoration, and neuroprotection through retinoprotective and neuroprotective effects.

What is the amino acid sequence of Epithalon?

The amino acid sequence is H-Ala-Glu-Asp-Gly-OH (AEDG).

What is the molecular weight of Epithalon?

The molecular weight is 390.35 g/mol (free base).

What is the molecular formula of Epithalon?

The molecular formula is C₁₄H₂₂N₄O₉.

What is the CAS number of Epithalon?

The CAS number is 307297-39-8.

Is Epithalon synthetic?

Yes, Epithalon is a synthetic peptide produced through solid-phase peptide synthesis.

What research exists on Epithalon?

Research on Epithalon includes studies demonstrating telomerase activation and telomere elongation in human cell lines, retinoprotective effects in animal models, pineal gland function restoration, neuroimmunoendocrine regulation, and tumor-suppressing effects in transgenic mice.

Is Epithalon approved as a medicine?

No. Regulatory authorities have not approved Epithalon as a medicine, pharmaceutical, or therapeutic agent. All published research is primarily preclinical with some early-stage clinical data.

Is Epithalon intended for human use?

No. Epithalon is intended for laboratory research use only and is not for human consumption, injection, or therapeutic application.

Where can I buy Epithalon 25mg in Switzerland?

You can buy Epithalon 25mg in Switzerland from Core Peptides, a trusted research peptide supplier serving the Swiss scientific community.

How should researchers evaluate Epithalon quality?

Researchers should look for identity confirmation via mass spectrometry, purity data from HPLC, batch traceability, and a Certificate of Analysis.

Related Research Compounds

Researchers interested in Epithalon may also find the following related compounds relevant to their work:

• Cortagen — A related Khavinson tetrapeptide (Ala-Glu-Asp-Pro) researched for neuroprotection and CNS gene regulation.
• Bronchogen — A related Khavinson tetrapeptide (Ala-Glu-Asp-Leu) researched for bronchial epithelium and pulmonary tissue.
• Cardiogen — A related Khavinson tetrapeptide (Ala-Glu-Asp-Arg) researched for cardiac tissue and cardiomyocyte function.
• Melatonin — A hormone researched for sleep regulation and circadian rhythm studies.

Explore Anti-Aging & Longevity

Epithalon belongs to the Anti-Aging & Longevity category of research compounds. Anti-Aging & Longevity products are studied for their potential roles in cellular longevity, telomere biology, and age-related pathway modulation. Generally, researchers who buy Epithalon 25mg in Switzerland often pair it with related compounds in this category to explore complementary pathways in aging and longevity research.

Explore Cellular Research & Signaling

Researchers studying telomerase activation, epigenetic regulation, and cellular signaling may also find relevant compounds in the Cellular Research & Signaling category. Epithalon’s interactions with telomerase, histones, and gene expression pathways make it a valuable tool for investigating fundamental cellular signaling and epigenetic mechanisms.

Further Research

For researchers seeking to deepen their understanding of Epithalon and its research applications, the following areas may warrant further investigation:

• The relationship between Epithalon-mediated telomerase activation and specific downstream effects on cellular senescence and longevity
• Comparative studies between Epithalon and other Khavinson peptides in various aging and tissue-specific models
• The potential role of Epithalon in modulating circadian rhythm and neuroimmunoendocrine system function
• Mechanistic studies on Epithalon’s interaction with histones and its functional consequences for gene transcription
• Exploration of Epithalon’s effects on different cell types and tissue systems beyond the pineal gland

Research Disclaimer

Epithalon is a research peptide supplied for laboratory research use only. Researchers must not use it for human consumption, injection, or any form of therapeutic application. Moreover, this product is not a medicine, pharmaceutical, or medical device. Furthermore, Swissmedic, the FDA, EMA, or any other regulatory authority have not approved it for human use. Researchers should consult Swissmedic for applicable regulations and guidance on research peptide handling in Switzerland.

Generally, the information provided on this page is for educational and scientific reference purposes only. Therefore, it does not constitute medical advice, treatment recommendations, or dosing instructions. Ultimately, researchers bear the responsibility for ensuring that their use of this product complies with all applicable laws, regulations, and institutional guidelines.