{"id":2800,"date":"2026-08-24T21:43:45","date_gmt":"2026-08-24T21:43:45","guid":{"rendered":"https:\/\/officialcorepeptides.brandloom.net\/fr\/?post_type=product&p=2800"},"modified":"2026-08-24T21:43:45","modified_gmt":"2026-08-24T21:43:45","slug":"buy-cardiogen-20mg-in-switzerland","status":"publish","type":"product","link":"https:\/\/officialcorepeptides.ch\/fr\/product\/buy-cardiogen-20mg-in-switzerland\/","title":{"rendered":"Cardiogen (20MG)"},"content":{"rendered":"

What Is Cardiogen and Why Buy It for Research?<\/strong><\/h2>\n

Buy Cardiogen 20mg in Switzerland for research into tissue-specific gene regulation, cardiac cell biology, and cardioprotective mechanisms. Specifically, Cardiogen (also known as AEDR or Ala-Glu-Asp-Arg) is a synthetic tetrapeptide composed of four amino acids with the sequence Ala-Glu-Asp-Arg (AEDR). It belongs to the Cytogen class of Khavinson peptide bioregulators\u2014short synthetic peptides (2-4 amino acids) developed to regulate gene expression in their target organs through direct interaction with DNA and chromatin.<\/p>\n

Khavinson’s team developed Cardiogen in the 1980s and 1990s at the Russian Military Medical Academy after identifying recurring short peptide sequences from heart tissue extracts. Researchers designed the synthetic AEDR tetrapeptide to reproduce the biological activity of these endogenous cardiac peptide fragments. In scientific research, Cardiogen serves as a molecular tool for studying tissue-specific transcriptional regulation in cardiac-derived cell and tissue systems. Furthermore, Core Peptides supplies Cardiogen as a lyophilized powder in a 20mg format exclusively for laboratory use. Therefore, researchers seeking to source this compound for their work will find it readily available when they buy Cardiogen 20mg in Switzerland.<\/p>\n

Cardiogen Research Overview: Buy Cardiogen 20mg in Switzerland for Cardiac Gene Expression Studies<\/strong><\/h2>\n

Centrally, research into Cardiogen has focused on its function as a tissue-specific bioregulator targeting cardiac tissue. Endogenously, cardiomyocytes play a critical role in maintaining cardiac function through contractile protein synthesis, calcium handling, and oxidative stress defense. Researchers designed Cardiogen based on amino acid analysis of polypeptide extracts from heart tissue, with the aim of restoring and maintaining normal function of cardiac cells.<\/p>\n

Unlike conventional pharmaceutical agents that act through receptor-mediated signaling (GPCRs), Khavinson’s bioregulator theory proposes that AEDR penetrates cell nuclei and interacts directly with DNA at specific sequence motifs and with histone proteins, thereby modulating transcription of tissue-relevant genes. In vitro studies have demonstrated that Cardiogen interacts with DNA, strongly quenching fluorescence of methylated and unmethylated \u03bb phage DNA-ethidium bromide complexes. Researchers believe this direct nuclear interaction increases transcriptional availability at cardiac-specific gene promoter regions, enabling expression of genes involved in myocardial differentiation and maintenance. Accordingly, researchers who buy Cardiogen 20mg in Switzerland from Core Peptides can support their investigations into peptide-DNA interactions, gene expression regulation, and cardiac biology.<\/p>\n

How Does Cardiogen Work in Research?<\/strong><\/h2>\n

Mechanistically, Cardiogen’s proposed action involves functioning as a nuclear-targeting peptide that modulates gene expression in cardiac cells through direct DNA and histone interactions. The peptide binds to histones H1, H2b, H3, and H4 at its N-terminal peptide-binding motif. Researchers believe this interaction increases the transcriptional availability of cardiac-specific gene promoter regions.<\/p>\n

For example, a 2012 study published in the Bulletin of Experimental Biology and Medicine demonstrated that the tetrapeptide H-Ala-Glu-Asp-Arg-OH enhances the expression of cytoskeletal proteins (actin, tubulin, vimentin) by 2 to 5 times and nuclear matrix proteins (lamin A, lamin C) by 2 to 3 times in cultured mouse embryonic fibroblasts. Consequently, the study concluded that the previously reported cardioprotective activity of this tetrapeptide depends on its capacity to activate synthesis of cytoskeletal and nuclear matrix proteins, which stimulates cell proliferation and reduces apoptosis.<\/p>\n

Furthermore, in organotypic myocardial tissue culture studies by Chalisova et al. (2009), Cardiogen uniquely stimulated cardiomyocyte proliferation at picomolar concentrations (10\u207b\u00b9\u00b2 M) in tissue from both young (3-month-old) and aged (24-month-old) rats. Critically, the same concentration of any individual natural amino acid failed to reproduce this effect, confirming that the biological activity resides in the intact tetrapeptide sequence rather than its constituent amino acids. Immunohistochemical analysis revealed that Cardiogen reduced p53 tumor suppressor protein expression in myocardial tissue, indicating suppression of apoptotic pathways. This dual action\u2014stimulating proliferation while inhibiting programmed cell death\u2014is particularly significant for cardiac biology, where cardiomyocyte loss through apoptosis is a hallmark of aging and ischemic heart disease.<\/p>\n

Why Is Cardiogen Studied in Switzerland?<\/strong><\/h2>\n

Primarily, researchers study Cardiogen because it represents a well-characterized tetrapeptide bioregulator that enables investigation of tissue-specific gene expression, DNA interaction, and cardiac cell biology. In fact, this compound offers a focused tool for studying the molecular mechanisms underlying cardiomyocyte function, apoptosis regulation, and cytoprotective signaling.<\/p>\n

Research has demonstrated Cardiogen’s effects across multiple domains. In organotypic tissue culture, Cardiogen showed a stimulating effect in heart tissue explants from both young and aged rats. Moreover, researchers have studied the peptide for its ability to modulate gene expression programs in cardiomyocyte and cardiac-fibroblast models, including transcripts associated with contractile proteins, calcium handling, and oxidative stress defense. Additionally, investigators have examined Cardiogen for its effects on chromatin activation and its potential role in modulating age-related cardiac decline. Ultimately, researchers who buy Cardiogen 20mg in Switzerland gain access to a research tool that may help uncover mechanisms underlying cardiac function, myocardial protection, and tissue-specific gene regulation.<\/p>\n

Cardiogen Research Areas in Laboratory Studies<\/strong><\/h2>\n\n\n\n\n\n\n\n\n\n\n\n\n
Research Area<\/th>\nFocus<\/th>\nEvidence Level<\/th>\n<\/tr>\n<\/thead>\n
Gene Expression Regulation<\/td>\nCardiac-specific gene transcription, promoter activity modulation<\/td>\nMechanistic \/ In Vitro<\/td>\n<\/tr>\n
DNA and Chromatin Interaction<\/td>\nPeptide-DNA binding, histone interaction, chromatin conformation<\/td>\nMechanistic<\/td>\n<\/tr>\n
Cardiomyocyte Proliferation<\/td>\nCell cycle activation, myocardial regeneration, tissue growth<\/td>\nEx Vivo \/ Preclinical<\/td>\n<\/tr>\n
Apoptosis Regulation<\/td>\np53 suppression, anti-apoptotic signaling, cell survival<\/td>\nMechanistic \/ Ex Vivo<\/td>\n<\/tr>\n
Cytoskeletal Protein Synthesis<\/td>\nActin, tubulin, vimentin expression, cellular structure<\/td>\nMechanistic \/ In Vitro<\/td>\n<\/tr>\n
Nuclear Matrix Protein Synthesis<\/td>\nLamin A, lamin C expression, nuclear integrity<\/td>\nMechanistic \/ In Vitro<\/td>\n<\/tr>\n
Cardiac Aging Research<\/td>\nAge-related functional decline, cellular senescence<\/td>\nPreclinical<\/td>\n<\/tr>\n
Cardioprotection<\/td>\nIschemic injury, oxidative stress, myocardial protection<\/td>\nPreclinical<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Cardiogen Compared With Related Research Compounds<\/strong><\/h2>\n\n\n\n\n\n\n\n\n
Compound<\/th>\nResearch Focus<\/th>\nMechanism \/ Target<\/th>\nKey Difference<\/th>\n<\/tr>\n<\/thead>\n
Cardiogen (AEDR)<\/td>\nCardiac tissue, cardiomyocyte function<\/td>\nDNA interaction, chromatin modulation, gene expression<\/td>\nTetrapeptide; heart tissue-specific bioregulator<\/td>\n<\/tr>\n
Epitalon (AEDG)<\/td>\nPineal gland, aging, circadian rhythms<\/td>\nDNA interaction, telomerase activation<\/td>\nDifferent target tissue; Ala-Glu-Asp-Gly sequence<\/td>\n<\/tr>\n
Bronchogen (AEDL)<\/td>\nBronchial epithelium, pulmonary research<\/td>\nDNA interaction, gene expression modulation<\/td>\nDifferent target tissue; Ala-Glu-Asp-Leu sequence<\/td>\n<\/tr>\n
Cortagen (AEDP)<\/td>\nNervous system, brain<\/td>\nDNA interaction, neuroprotection<\/td>\nDifferent target tissue; Ala-Glu-Asp-Pro sequence<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Comparatively, Cardiogen differs from other Khavinson peptide bioregulators in its tissue specificity and amino acid sequence. On the one hand, Epitalon (Ala-Glu-Asp-Gly) targets pineal gland function and aging-related processes, while Bronchogen (Ala-Glu-Asp-Leu) focuses on bronchial and pulmonary tissue. On the other hand, Cardiogen (Ala-Glu-Asp-Arg) is specifically designed for cardiac tissue research, with demonstrated effects on cardiomyocyte proliferation, cytoskeletal protein synthesis, and apoptosis suppression. In contrast, Cortagen (Ala-Glu-Asp-Pro) targets nervous system tissues.<\/p>\n

Research Applications for Cardiogen in Switzerland<\/strong><\/h2>\n

Scientists have investigated Cardiogen across several research domains:<\/p>\n