{"id":2884,"date":"2026-08-25T12:27:48","date_gmt":"2026-08-25T11:27:48","guid":{"rendered":"https:\/\/officialcorepeptides.brandloom.net\/en\/?post_type=product&p=2884"},"modified":"2026-08-25T12:27:48","modified_gmt":"2026-08-25T11:27:48","slug":"buy-melanotan-1-10mg-in-switzerland","status":"publish","type":"product","link":"https:\/\/officialcorepeptides.ch\/en\/product\/buy-melanotan-1-10mg-in-switzerland\/","title":{"rendered":"Melanotan 1 (10MG)"},"content":{"rendered":"

What Is Melanotan 1 and Why Buy It for Research?<\/strong><\/h2>\n

Buy Melanotan 1 10mg in Switzerland for research into melanocortin receptor signaling, melanogenesis, and photoprotective mechanisms. Specifically, Melanotan 1 (also known as Afamelanotide, [Nle4,D-Phe7]-\u03b1-MSH, or NDP-\u03b1-MSH) is a synthetic 13-amino acid peptide analog of \u03b1-melanocyte stimulating hormone (\u03b1-MSH). The peptide has the sequence Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH\u2082 and is a potent, non-selective melanocortin receptor agonist.<\/p>\n

Researchers developed Melanotan 1 through specific amino acid substitutions\u2014replacing methionine with norleucine at position 4 and substituting L-phenylalanine with D-phenylalanine at position 7\u2014which enhance the peptide’s stability, potency, and resistance to enzymatic degradation compared to native \u03b1-MSH. The peptide has a molecular weight of 1,646.85 g\/mol, a molecular formula of C\u2087\u2088H\u2081\u2081\u2081N\u2082\u2081O\u2081\u2089, and the CAS number 75921-69-6.<\/p>\n

In scientific research, Melanotan 1 serves as a molecular tool for studying MC1R-mediated signaling pathways, melanogenesis regulation, and pigmentation mechanisms. Furthermore, Core Peptides supplies Melanotan 1 as a lyophilized powder in a 10mg format exclusively for laboratory use. Therefore, researchers seeking to source this compound for their work will find it readily available when they buy Melanotan 1 10mg in Switzerland.<\/p>\n

Melanotan 1 Research Overview: Buy Melanotan 1 10mg in Switzerland for MC1R Studies<\/strong><\/h2>\n

Centrally, research into Melanotan 1 has focused on its function as a potent melanocortin-1 receptor (MC1R) agonist that stimulates melanogenesis and pigmentation. Melanotan 1 has high binding affinity for MC1R, a G-protein-coupled receptor that melanocytes express in the epidermis. Upon binding, MC1R activates adenylate cyclase, elevating cyclic AMP (cAMP) levels, which triggers a signaling cascade that upregulates tyrosinase and other melanogenic enzymes, ultimately leading to increased melanin production.<\/p>\n

Unlike native \u03b1-MSH, Melanotan 1 is significantly more resistant to enzymatic breakdown, which means the stimulus received by MC1R is more potent and sustained. Furthermore, Melanotan 1 can activate receptors that have mutations at various sites in the seven transmembrane domains\u2014a feature not shared with natural \u03b1-MSH. This makes it a valuable tool for studying MC1R function and polymorphisms.<\/p>\n

In human research, Melanotan 1 has been shown to induce skin tanning and provide photoprotection. One clinical study demonstrated that tanning was achieved in 3 of 4 subjects receiving MT-1, with these subjects having 47% fewer sunburn cells at irradiated sites. Researchers can safely combine Melanotan 1 with UV-B light or sunlight, and it appears to act synergistically in the tanning response to light. Accordingly, researchers who buy Melanotan 1 10mg in Switzerland from Core Peptides can support their investigations into MC1R signaling, melanogenesis regulation, and photoprotective mechanisms.<\/p>\n

How Does Melanotan 1 Work in Research?<\/strong><\/h2>\n

Mechanistically, Melanotan 1’s proposed action involves functioning as a melanocortin receptor agonist that activates MC1R-mediated signaling to stimulate melanin production and provide photoprotection. The peptide operates through several interconnected mechanisms.<\/p>\n

MC1R Receptor Binding and Activation<\/strong><\/h3>\n

Melanotan 1 binds with high affinity to the melanocortin-1 receptor (MC1R) on melanocytes. This binding activates the receptor, triggering intracellular signaling cascades. The peptide is more resistant to breakdown than natural \u03b1-MSH, meaning the stimulus received by MC1R is more potent and sustained.<\/p>\n

cAMP-Mediated Signaling Cascade<\/strong><\/h3>\n

Upon MC1R activation, the receptor couples to G-proteins and stimulates adenylate cyclase, which converts ATP to cyclic AMP (cAMP). The resulting elevation in cAMP levels activates protein kinase A (PKA), which phosphorylates and activates the transcription factor CREB (cAMP response element-binding protein). Consequently, this upregulates the expression of melanogenic enzymes, including tyrosinase, TRP-1, and TRP-2.<\/p>\n

Melanin Production and Pigmentation<\/strong><\/h3>\n

Melanotan 1 stimulates melanogenesis\u2014the production of melanin\u2014by mimicking the actions of \u03b1-MSH on MC1R. The peptide promotes the synthesis of eumelanin (brown\/black pigment), which provides photoprotection against UV radiation. This melanogenic activity underlies the peptide’s ability to induce skin tanning and reduce UV-induced skin damage.<\/p>\n

Photoprotection and DNA Repair<\/strong><\/h3>\n

Beyond melanin production, Melanotan 1 provides photoprotective effects through multiple mechanisms. Studies have shown that the peptide reduces sunburn cell formation, indicating protection against UV-induced DNA damage. Additionally, Melanotan 1 acts synergistically with UV-B light or sunlight in the tanning response.<\/p>\n

Why Is Melanotan 1 Studied in Switzerland?<\/strong><\/h2>\n

Primarily, researchers study Melanotan 1 because it represents a well-characterized \u03b1-MSH analog that enables investigation of MC1R signaling, melanogenesis, and photoprotective mechanisms. In fact, this compound offers a focused tool for studying the molecular mechanisms underlying pigmentation, UV protection, and melanocortin receptor pharmacology.<\/p>\n

Research has demonstrated Melanotan 1’s relevance across multiple domains. The peptide has been studied for its potential in treating erythropoietic protoporphyria (EPP), a rare genetic disorder causing severe photosensitivity, where it is approved as an orphan drug. Additionally, investigators have examined Melanotan 1 for its applications in vitiligo, skin cancer chemoprevention, and photodermatoses.<\/p>\n

Furthermore, researchers have studied Melanotan 1 for its potential to reduce UV-induced skin damage and act as a chemopreventive agent against sunlight-induced skin cancer. The peptide has also been investigated for its effects on inflammation and, in some studies, male erectile dysfunction. Ultimately, researchers who buy Melanotan 1 10mg in Switzerland gain access to a comprehensive research tool for investigating MC1R signaling, melanogenesis, photoprotection, and pigmentation-related disorders.<\/p>\n

Melanotan 1 Research Areas in Laboratory Studies<\/strong><\/h2>\n\n\n\n\n\n\n\n\n\n\n\n
Research Area<\/th>\nFocus<\/th>\nEvidence Level<\/th>\n<\/tr>\n<\/thead>\n
MC1R Receptor Pharmacology<\/td>\nReceptor binding, cAMP signaling, MC1R activation, receptor polymorphisms<\/td>\nMechanistic \/ In Vitro<\/td>\n<\/tr>\n
Melanogenesis and Pigmentation<\/td>\nMelanin synthesis, tyrosinase regulation, eumelanin production<\/td>\nMechanistic \/ In Vitro \/ In Vivo<\/td>\n<\/tr>\n
Photoprotection<\/td>\nUV protection, sunburn cell reduction, DNA damage prevention<\/td>\nClinical \/ Preclinical<\/td>\n<\/tr>\n
Skin Cancer Research<\/td>\nChemoprevention, melanoma research, photodermatoses<\/td>\nPreclinical \/ Clinical<\/td>\n<\/tr>\n
Porphyria and Photosensitivity<\/td>\nErythropoietic protoporphyria, photoprotection, orphan drug research<\/td>\nClinical<\/td>\n<\/tr>\n
Inflammation Research<\/td>\nAnti-inflammatory effects, melanocortin-mediated immune modulation<\/td>\nPreclinical<\/td>\n<\/tr>\n
Pharmacokinetics<\/td>\nHalf-life studies, stability, delivery systems, implant formulations<\/td>\nPharmacokinetic<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Melanotan 1 Compared With Related Research Compounds<\/strong><\/h2>\n\n\n\n\n\n\n\n\n
Compound<\/th>\nResearch Focus<\/th>\nMechanism \/ Target<\/th>\nKey Difference<\/th>\n<\/tr>\n<\/thead>\n
Melanotan 1 (Afamelanotide)<\/td>\nMC1R signaling, melanogenesis, photoprotection<\/td>\nNon-selective MCR agonist, high MC1R affinity<\/td>\n13-amino acid linear peptide; FDA-approved orphan drug; higher MC1R selectivity<\/td>\n<\/tr>\n
Melanotan 2<\/td>\nMC1R, MC3R, MC4R, MC5R signaling<\/td>\nNon-selective MCR agonist<\/td>\nCyclic peptide; broader receptor binding; lower MC1R selectivity; more side effects<\/td>\n<\/tr>\n
\u03b1-MSH<\/td>\nNative melanocortin signaling<\/td>\nMCR agonist (non-selective)<\/td>\nNative 13-amino acid peptide; shorter half-life; less stable<\/td>\n<\/tr>\n
NDP-MSH<\/td>\nMelanocortin receptor research<\/td>\nMCR agonist<\/td>\nSuperpotent analog; similar to Melanotan 1; research use<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Comparatively, Melanotan 1 differs from Melanotan 2 in its receptor selectivity and side-effect profile. On the one hand, Melanotan 1 exhibits high selectivity for MC1R, making it more specific for pigmentation-related research with minimal off-target effects. On the other hand, Melanotan 2 is a non-selective agonist that binds effectively to MC1R, MC3R, MC4R, and MC5R, resulting in a broader range of effects but also more side effects. In contrast, native \u03b1-MSH has a shorter half-life and is less stable than either synthetic analog.<\/p>\n

Research Applications for Melanotan 1 in Switzerland<\/strong><\/h2>\n

Scientists have investigated Melanotan 1 across several research domains:<\/p>\n