Cortagen –(20MG)

What Is Cortagen and Why Buy It for Research?

Buy Cortagen 20mg in Switzerland for research into neuroprotection, central nervous system gene regulation, and tissue-specific bioregulation. Specifically, Cortagen (also known as AEDP or Ala-Glu-Asp-Pro) is a synthetic tetrapeptide composed of four amino acids with the sequence Ala-Glu-Asp-Pro (AEDP). Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology developed Cortagen through directed synthesis based on amino acid analysis of the natural brain cortex peptide preparation Cortexin.

Cortagen is structurally similar to Epithalon (AEDG) but differs by one C-terminal residue, with proline replacing glycine, conferring distinct central nervous system tissue specificity. In scientific research, Cortagen serves as a molecular tool for studying tissue-specific gene expression regulation in neural and nervous system experimental systems.

Researchers consider this peptide particularly valuable for investigating neuroprotective mechanisms, chromatin remodeling, and nerve regeneration. Furthermore, Core Peptides supplies Cortagen as a lyophilized powder in a 20mg format exclusively for laboratory use. Therefore, researchers seeking to source this compound for their work will find it readily available when they buy Cortagen 20mg in Switzerland.

Cortagen Research Overview: Buy Cortagen 20mg in Switzerland for Neuroprotection Studies

Centrally, research into Cortagen has focused on its function as a tissue-specific bioregulator targeting the brain and central nervous system. Researchers originally identified the peptide as a primary active component of Cortexin, a mixture of peptides derived from cow brain cortex tissue. The synthetic AEDP tetrapeptide was designed to reproduce the biological activity of these endogenous brain cortex peptide fragments.

Unlike conventional pharmaceutical agents that act through receptor-mediated signaling, Khavinson’s bioregulator theory proposes that Cortagen penetrates cell nuclei and interacts directly with DNA and chromatin, thereby modulating transcription of tissue-relevant genes. Research has demonstrated that Cortagen induces deheterochromatinization (unrolling/decondensation) of total heterochromatin and activates synthetic processes of ribosomal genes.

This epigenetic regulation of “aged” heterochromatin is a key mechanism by which Cortagen is proposed to exert its effects. Notably, Cortagen has demonstrated a pronounced therapeutic effect upon the structural and functional posttraumatic recovery of peripheral nerve tissue in humans. Accordingly, researchers who buy Cortagen 20mg in Switzerland from Core Peptides can support their investigations into neuroprotection, gene expression regulation, and nervous system biology.

How Does Cortagen Work in Research?

Mechanistically, Cortagen’s proposed action involves functioning as a nuclear-targeting peptide that modulates gene expression through epigenetic chromatin remodeling. The peptide operates through several interconnected mechanisms.

Chromatin Remodeling and Gene Activation

Cortagen induces deheterochromatinization—the unrolling and decondensation of heterochromatin—effectively releasing locked genes for transcriptional activation. This process activates synthetic processes of ribosomal genes as a result of deheterochromatinization of satellite stalks of acrocentric chromosomes. Through this epigenetic regulation, Cortagen modulates gene expression patterns in a tissue-specific manner, upregulating regenerative pathways and downregulating inflammatory or stress-related pathways.

Neuroprotective Activity

Cortagen has been shown to protect brain tissue against ischemic damage in experimental models. Studies investigating the effect of Cortagen on the volume of cerebral cortex infarct area and on the dynamics of subsequent neurological deficits in rat stroke models indicate that Cortagen is a promising neuroprotective agent. Furthermore, the peptide modulates the electrical activity of neurons, moderately changing the resting potential, action potential, and impulse frequency in a manner interpreted as activating action.

Nerve Regeneration

Research has demonstrated Cortagen’s effects on the restoration of injured nerve function. Studies on the effect of tetrapeptide Cortagen on regeneration of sciatic nerve have shown its capacity to support structural and functional recovery of peripheral nerve tissue.

Gene Expression Modulation

Microarray studies have elucidated the effect of Cortagen on gene expression in mouse heart, facilitating understanding of the mechanisms responsible for this peptide’s biological effects. Additionally, Cortagen has been shown to modulate the expression of IL-2 gene in vivo in cells of some hypothalamic structures. Moreover, Cortagen influences free-radical processes, decreasing the content of lipid peroxidation products and reducing oxidative modification of proteins.

Why Is Cortagen Studied in Switzerland?

Primarily, researchers study Cortagen because it represents a well-characterized tetrapeptide bioregulator that enables investigation of neuroprotection, epigenetic regulation, and tissue-specific gene expression. In fact, this compound offers a focused tool for studying the molecular mechanisms underlying brain function, nerve regeneration, and age-related cognitive decline.

Research has demonstrated Cortagen’s relevance across multiple domains. The evidence base for Cortagen consists of approximately 13 total studies with only one human study and no randomized controlled trials. These studies have examined Cortagen’s effects on: structural and functional posttraumatic recovery of peripheral nerve tissue; neuroprotection in ischemia-reperfusion models; gene expression in neural, cardiac, and immune tissues through epigenetic chromatin remodeling; and chromatin decondensation and ribosomal gene activation.

Cortagen has also been shown to accelerate the recovery of disturbed individual behavior of ischemic rats with different resistance to hypoxia. Furthermore, studies in Drosophila models for neurodegenerative disorders have explored Cortagen’s therapeutic activity. Ultimately, researchers who buy Cortagen 20mg in Switzerland gain access to a comprehensive research tool for investigating neuroprotection, gene regulation, and nervous system biology.

Cortagen Research Areas in Laboratory Studies

Research Area	Focus	Evidence Level
Neuroprotection	Ischemia-reperfusion injury, stroke models, infarct volume reduction	Animal / Preclinical
Chromatin Remodeling	Deheterochromatinization, ribosomal gene activation, epigenetic regulation	Mechanistic
Nerve Regeneration	Sciatic nerve repair, peripheral nerve recovery, posttraumatic recovery	Animal / Preclinical
Gene Expression Modulation	Cardiac gene expression, IL-2 expression, tissue-specific regulation	Mechanistic / In Vivo
Neuronal Activity	Resting potential modulation, action potential, impulse frequency	Mechanistic / In Vitro
Cognitive and Neurodegenerative Research	Age-related cognitive decline, Drosophila neurodegeneration models	Preclinical
Free-Radical Processes	Lipid peroxidation reduction, oxidative protein modification	Mechanistic / In Vivo

Cortagen Compared With Related Research Compounds

Compound	Research Focus	Mechanism / Target	Key Difference
Cortagen (AEDP)	Brain and CNS, neuroprotection, nerve regeneration	Chromatin remodeling, gene expression modulation	Tetrapeptide; Ala-Glu-Asp-Pro sequence; CNS-specific bioregulator
Epithalon (AEDG)	Pineal gland, aging, circadian rhythms	DNA interaction, telomerase activation	Different target tissue; Ala-Glu-Asp-Gly sequence
Bronchogen (AEDL)	Bronchial epithelium, pulmonary research	DNA interaction, gene expression modulation	Different target tissue; Ala-Glu-Asp-Leu sequence
Cardiogen (AEDR)	Cardiac tissue, cardiomyocyte function	DNA interaction, chromatin modulation	Different target tissue; Ala-Glu-Asp-Arg sequence

Comparatively, Cortagen differs from other Khavinson peptide bioregulators in its tissue specificity and amino acid sequence. On the one hand, Epithalon (Ala-Glu-Asp-Gly) targets pineal gland function and aging-related processes. On the other hand, Cortagen (Ala-Glu-Asp-Pro) is specifically designed for brain and central nervous system research, with demonstrated effects on neuroprotection, chromatin remodeling, and nerve regeneration. In contrast, Bronchogen targets bronchial epithelium while Cardiogen focuses on cardiac tissue.

Research Applications for Cortagen in Switzerland

Scientists have investigated Cortagen across several research domains:

• Neuroprotection Studies: Researchers use Cortagen to investigate ischemic injury, stroke models, and neuroprotective mechanisms in preclinical studies.
• Chromatin and Epigenetic Research: The peptide serves as a tool for studying deheterochromatinization, ribosomal gene activation, and epigenetic regulation.
• Nerve Regeneration Studies: Investigations have explored Cortagen’s effects on peripheral nerve recovery and posttraumatic nerve repair.
• Gene Expression Research: Cortagen is used to study tissue-specific gene regulation in neural, cardiac, and immune tissues.
• Neuronal Activity Studies: Research has examined Cortagen’s effects on neuronal resting potential, action potential, and impulse frequency.
• Neurodegenerative Disease Models: Studies have investigated Cortagen’s therapeutic activity in Drosophila models of neurodegenerative disorders.

Evidently, researchers who buy Cortagen 20mg in Switzerland gain a valuable addition to any laboratory toolkit focused on neuroprotection, gene regulation, and nervous system biology.

Cortagen Product Specifications

Specification	Details
Product Name	Cortagen (AEDP)
Alternative Names	AEDP, Ala-Glu-Asp-Pro, Cortagen peptide bioregulator
Amount	20mg
Form	Lyophilized powder (white to off-white)
Purity	Not verified
Amino Acid Sequence	H-Ala-Glu-Asp-Pro-OH (AEDP)
Sequence (3-letter)	Ala-Glu-Asp-Pro
Peptide Length	4 amino acids (tetrapeptide)
Molecular Formula	C₁₇H₂₆N₄O₉
Molecular Weight	430.41 g/mol
CAS Number	335591-03-2
Research Category	Cognitive & Nootropic / Anti-Aging & Longevity
Research Use	Laboratory research use only
CoA	Available upon request (not verified)
Storage	Lyophilized powder should be stored desiccated at -20°C or below, protected from light
Solubility	Soluble in water and buffered aqueous solutions

How to Evaluate Cortagen Quality for Research

When sourcing Cortagen peptide for laboratory research, researchers should consider several quality indicators:

• Identity Confirmation: Analytical techniques such as mass spectrometry should confirm the compound’s molecular weight (430.41 g/mol) and sequence (H-Ala-Glu-Asp-Pro-OH).
• Purity Assessment: High-performance liquid chromatography (HPLC) should verify purity, with ≥98% considered standard for research-grade material.
• Batch Traceability: Lot numbers and batch information enable researchers to track specific production runs.
• Certificate of Analysis: A CoA should accompany the product, detailing analytical testing results including HPLC purity and identity confirmation.
• Labeling Accuracy: Proper labeling should clearly indicate the product name, amount (20mg), sequence, molecular formula, CAS number, and storage recommendations.
• Storage Conditions: Appropriate storage at -20°C or below in desiccated, dark conditions helps maintain peptide stability.

Understanding the Certificate of Analysis

Typically, a Certificate of Analysis (CoA) accompanies research peptides and provides information about the specific batch’s analytical testing. For example, a CoA may include product identity confirmation, purity percentage as determined by HPLC, batch or lot number for traceability, analytical methods used (e.g., mass spectrometry, HPLC), and a physical description of the product.

Nevertheless, it is important to note that a CoA does not establish safety, efficacy, therapeutic effectiveness, or suitability for human use. Instead, it serves as a quality control document that helps researchers verify the identity and purity of the peptide they are using in their laboratory investigations.

Storage and Stability of Cortagen

Core Peptides supplies Cortagen as a lyophilized (freeze-dried) powder. To maintain stability and integrity:

• Store the lyophilized powder desiccated at -20°C or below for long-term storage
• Store at 4°C for short-term storage if frequent access is required
• Avoid repeated freeze-thaw cycles
• Weigh under dry conditions; the peptide is hygroscopic
• Reconstitute only immediately before use with appropriate sterile solvents (sterile water or buffered aqueous solutions)
• Inject solvent slowly against the inner wall of the vial; avoid vigorous agitation during dissolution
• Filter sterilize if required (e.g., 0.22 µm) immediately prior to use
• Aliquot and store reconstituted solutions at -20°C or below to minimize degradation
• Protect from light and moisture; prolonged exposure to light, elevated temperature, or aqueous environments may reduce stability

Frequently Asked Questions About Buying Cortagen 20mg in Switzerland

What is Cortagen?

Specifically, Cortagen (AEDP) is a synthetic tetrapeptide with the amino acid sequence Ala-Glu-Asp-Pro (AEDP). It is a tissue-specific bioregulator developed by Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology as a brain cortex-specific bioregulator.

What is Cortagen researched for?

Primarily, researchers study Cortagen for its role in neuroprotection, central nervous system gene regulation, and nerve regeneration. Studies have investigated its effects on chromatin remodeling, ischemic injury, gene expression modulation, and neuronal activity.

How does Cortagen work?

Mechanistically, Cortagen functions through epigenetic chromatin remodeling, inducing deheterochromatinization and activating ribosomal gene expression. It modulates gene expression in neural tissues through tissue-specific regulation and exhibits neuroprotective and nerve regenerative properties.

What is the amino acid sequence of Cortagen?

The amino acid sequence is H-Ala-Glu-Asp-Pro-OH (AEDP).

What is the molecular weight of Cortagen?

The molecular weight is 430.41 g/mol.

What is the molecular formula of Cortagen?

The molecular formula is C₁₇H₂₆N₄O₉.

What is the CAS number of Cortagen?

The CAS number is 335591-03-2.

Is Cortagen synthetic?

Yes, Cortagen is a synthetic peptide produced through solid-phase peptide synthesis.

What evidence exists for Cortagen?

Research on Cortagen includes studies on chromatin decondensation and ribosomal gene activation, neuroprotection in ischemia-reperfusion models, nerve regeneration in sciatic nerve injury models, and gene expression modulation in neural and cardiac tissues. The evidence base consists of approximately 13 total studies with only one human study and no randomized controlled trials.

Is Cortagen approved as a medicine?

No. Regulatory authorities have not approved Cortagen as a medicine, pharmaceutical, or therapeutic agent. All published research is primarily preclinical with limited clinical data.

Is Cortagen intended for human use?

No. Cortagen is intended for laboratory research use only and is not for human consumption, injection, or therapeutic application.

Where can I buy Cortagen 20mg in Switzerland?

You can buy Cortagen 20mg in Switzerland from Core Peptides, a trusted research peptide supplier serving the Swiss scientific community.

How should researchers evaluate Cortagen quality?

Researchers should look for identity confirmation via mass spectrometry, purity data from HPLC, batch traceability, and a Certificate of Analysis.

Related Research Compounds

Researchers interested in Cortagen may also find the following related compounds relevant to their work:

• Epithalon — A related Khavinson tetrapeptide (Ala-Glu-Asp-Gly) researched for pineal gland function, aging, and telomerase activation.
• Bronchogen — A related Khavinson tetrapeptide (Ala-Glu-Asp-Leu) researched for bronchial epithelium and pulmonary tissue.
• Cardiogen — A related Khavinson tetrapeptide (Ala-Glu-Asp-Arg) researched for cardiac tissue and cardiomyocyte function.
• BPC-157 — A peptide researched for tissue healing, gastrointestinal protection, and angiogenesis.

Explore Cognitive & Nootropic

Cortagen belongs to the Cognitive & Nootropic category of research compounds. Cognitive & Nootropic products are studied for their potential roles in neuroprotection, cognitive function, and nervous system regulation. Generally, researchers who buy Cortagen 20mg in Switzerland often pair it with related compounds in this category to explore complementary pathways in neuroprotection and cognitive research.

Explore Anti-Aging & Longevity

Researchers studying age-related cognitive decline, epigenetic regulation, and tissue-specific bioregulation may also find relevant compounds in the Anti-Aging & Longevity category. Cortagen’s effects on chromatin remodeling and gene expression make it a valuable tool for investigating age-related changes in gene expression and nervous system function.

Further Research

For researchers seeking to deepen their understanding of Cortagen and its research applications, the following areas may warrant further investigation:

• The relationship between Cortagen-mediated chromatin remodeling and specific downstream gene expression changes in neural tissues
• Comparative studies between Cortagen and other Khavinson peptides in various neuroprotection and tissue-specific models
• The potential role of Cortagen in modulating age-related cognitive decline and neurodegenerative processes
• Mechanistic studies on Cortagen’s interaction with chromatin and its functional consequences for gene transcription
• Exploration of Cortagen’s effects on different cell types and tissue systems beyond the central nervous system

Research Disclaimer

Cortagen is a research peptide supplied for laboratory research use only. Researchers must not use it for human consumption, injection, or any form of therapeutic application. Moreover, this product is not a medicine, pharmaceutical, or medical device. Furthermore, Swissmedic, the FDA, EMA, or any other regulatory authority have not approved it for human use. Researchers should consult Swissmedic for applicable regulations and guidance on research peptide handling in Switzerland.

Generally, the information provided on this page is for educational and scientific reference purposes only. Therefore, it does not constitute medical advice, treatment recommendations, or dosing instructions. Ultimately, researchers bear the responsibility for ensuring that their use of this product complies with all applicable laws, regulations, and institutional guidelines.

Finally, all research involving peptides should be conducted by qualified personnel in appropriate laboratory settings with proper safety protocols.